| 词条 | MK-886 |
| 释义 |
| verifiedrevid = 447198381 | ImageFile=L_663536.svg | ImageSize=200px | ImageAlt = Skeletal formula of L 663536 | ImageFile1 = L-663536-3D-spacefill.png | ImageSize1 = 180 | ImageAlt1 = Space-filling model of the L 663536 molecule | IUPACName = 3-[3-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-yl-indol-2-yl]-2,2-dimethyl-propanoic acid | OtherNames = L-663536 |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo=118414-82-7 | PubChem=105049 | SMILES= | MeSHName=L+663536 |Section2={{Chembox Properties | Formula=C27H34ClNO2S | MolarMass=472.083 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}MK-886, or L-663536, is a leukotriene antagonist. It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX),[1] and may help in treating atherosclerosis.[2] References1. ^{{cite journal|last1=Jun|first1=Joon-Il|last2=Lau|first2=Lester F.|journal=Nature Cell Biology|date=July 2010|volume=12|issue=7|pages=676–685|title=The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing|issn=1465-7392|pmid=20526329|pmc=2919364|doi=10.1038/ncb2070|url=http://www.nature.com/ncb/journal/v12/n7/full/ncb2070.html|accessdate=2011-08-28}} {{Leukotriene signaling modulators}}{{PPAR modulators}}{{biochem-stub}}2. ^{{cite journal |last1=Jawien|first1=J.|last2=Gajda|first2=M.|last3=Rudling|first3=M.|last4=Mateuszuk|first4=L.|last5=Olszanecki|first5=R.|last6=Guzik|first6=T. J.|last7=Cichocki|first7=T.|last8=Chlopicki|first8=S.|last9=Korbut|first9=R.|title=Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice |journal=European Journal of Clinical Investigation |volume=36 |issue=3 |pages=141–146 |date=March 2006 |pmid=16506957 |doi=10.1111/j.1365-2362.2006.01606.x}} 5 : Indoles|Thioethers|Chloroarenes|Isopropyl compounds|Carboxylic acids |
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