Mortal coil is a quotation from Shakespeare's Hamlet.

Mortal coil may also refer to:

• "Mortal Coil" (Star Trek: Voyager), a 1997 episode from the TV series Star Trek: Voyager
• Adrenalin Intelligence, a 1995 computer video game
• Mortal Coil, the fifth book in the Skulduggery Pleasant series
• Mortal Coils, a 1922 collection of short stories by Aldous Huxley
• This Mortal Coil, a British dream pop band
• This Mortal Coil (book), a 1947 collection of short stories by Cynthia Asquith
• This Mortal Coil (Redemption album), 2011
• "The Mortal Coil", a 1992 two-part episode from the radio show Adventures in Odyssey
• "This Mortal Coil" (Stargate Atlantis), a 2007 episode from the TV series Stargate Atlantis
• "This Mortal Coil", a song by Carcass

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