“MRNA (2'-O-methyladenosine-N6-)-methyltransferase”的意思、由来-开放百科全书

词条

MRNA (2'-O-methyladenosine-N6-)-methyltransferase

释义

References

{{enzyme
| Name = mRNA (2'-O-methyladenosine-N⁶-)-methyltransferase
| EC_number = 2.1.1.62
| CAS_number = 68009-87-0
| IUBMB_EC_number = 2/1/1/62
| GO_code = 0016422
| image =
| width =
| caption =
}}{{lowercase}}

In enzymology, a mRNA (2'-O-methyladenosine-N⁶-)-methyltransferase ({{EC number|2.1.1.62}}) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + m⁷G(5')pppAm S-adenosyl-L-homocysteine + m⁷G(5')pppm⁶Am (mRNA containing an N⁶,2'-O-dimethyladenosine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and m⁷G(5')pppAm, whereas its two products are S-adenosylhomocysteine and m⁷G(5')pppm⁶Am (mRNA containing an N⁶,2'-O-dimethyladenosine cap).

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N⁶-)-methyltransferase. Other names in common use include messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, S-adenosyl-L-methionine:mRNA, and (2'-O-methyladenosine-6-N-)-methyltransferase.

References

{{cite journal |vauthors=Keith JM, Ensinger MJ, Mose B | date = 1978 | title = HeLa cell RNA (2'-O-methyladenosine-N6-)-methyltransferase specific for the capped 5'-end of messenger RNA | journal = J. Biol. Chem. | volume = 253 | pages = 5033–9 | pmid = 670176 | issue = 14 }}

2 : EC 2.1.1|Enzymes of unknown structure

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