“MRNA (guanine-N7-)-methyltransferase”的意思、由来-开放百科全书

In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.

In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.^[1]^[2]^[3]

Nomenclature

The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:

Further reading

{{cite journal | vauthors = Ensinger MJ, Martin SA, Paoletti E, Moss B | date = 1975 | title = Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 72 | pages = 2525–9 | pmid = 1058472 | doi = 10.1073/pnas.72.7.2525 | issue = 7 | pmc = 432801 }}

{{cite journal | vauthors = Groner Y, Gilboa E, Aviv H | date = 1978 | title = Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates | journal = Biochemistry | volume = 17 | pages = 977–82 | pmid = 629955 | doi = 10.1021/bi00599a005 | issue = 6 }}

{{cite journal | vauthors = Martin SA, Moss B | date = 1975 | title = Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions | journal = J. Biol. Chem. | volume = 250 | pages = 9330–5 | pmid = 1194287 | issue = 24 }}

{{cite journal | vauthors = Martin SA, Paoletti E, Moss B | date = 1975 | title = Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions | journal = J. Biol. Chem. | volume = 250 | pages = 9322–9 | pmid = 1194286 | issue = 24 }}

{{cite journal | vauthors=Langberg SR, Moss B |title=Post-transcriptional modifications of mRNA. Purification and characterization of cap I and cap II RNA (nucleoside-2'-)-methyltransferases from HeLa cells. |journal=J. Biol. Chem. |volume=256 |issue= 19 |pages= 10054–60 |year= 1981 |pmid= 7275966 |doi= }}

{{cite journal | author=Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–13 |year= 1998 |pmid= 9455477 |doi=10.1093/dnares/4.5.307 |name-list-format=vanc| author2=Nagase T | author3=Nakajima D | display-authors=3 | last4=Seki | first4=N | last5=Ohira | first5=M | last6=Miyajima | first6=N | last7=Tanaka | first7=A | last8=Kotani | first8=H | last9=Nomura | first9=N }}

{{cite journal | vauthors=Tsukamoto T, Shibagaki Y, Niikura Y, Mizumoto K |title=Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 1 |pages= 27–34 |year= 1998 |pmid= 9790902 |doi= 10.1006/bbrc.1998.9402 }}

{{cite journal | vauthors=Saha N, Schwer B, Shuman S |title=Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16553–62 |year= 1999 |pmid= 10347220 |doi=10.1074/jbc.274.23.16553 }}

{{cite journal | author=Yamada-Okabe T |title=The Candida albicans gene for mRNA 5-cap methyltransferase: identification of additional residues essential for catalysis |journal=Microbiology |volume=145 |issue= 11|pages= 3023–33 |year= 2000 |pmid= 10589710 |doi= 10.1099/00221287-145-11-3023 |name-list-format=vanc| author2=Mio T | author3=Kashima Y | display-authors=3 | last4=Matsui | first4=M | last5=Arisawa | first5=M | last6=Yamada-Okabe | first6=H }}

{{cite journal | vauthors=Wen Y, Shatkin AJ |title=Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-α |journal=Genes Dev. |volume=14 |issue= 23 |pages= 2944–9 |year= 2001 |pmid= 11114884 |doi=10.1101/gad.848200 | pmc=317093 }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | vauthors=Shafer B, Chu C, Shatkin AJ |title=Human mRNA Cap Methyltransferase: Alternative Nuclear Localization Signal Motifs Ensure Nuclear Localization Required for Viability |journal=Mol. Cell. Biol. |volume=25 |issue= 7 |pages= 2644–9 |year= 2005 |pmid= 15767670 |doi= 10.1128/MCB.25.7.2644-2649.2005 | pmc=1061643 }}

2 : EC 2.1.1|Enzymes of known structure

Nomenclature

See also

References

Further reading