“Myxothiazol”的意思、由来-开放百科全书

词条

Myxothiazol

释义

{{unreferenced|date=May 2017}}{{chembox
| verifiedrevid = 431411079
| ImageFile=Myxothiazol.svg
| ImageSize=300px
| IUPACName=72'-[(1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl][2,4'-bithiazol]-4-yl3,5-dimethoxy-4-methyl- (2E,4R,5S,6E)-2,6-heptadienamide
| OtherNames=
|Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|??}}
| CASNo=76706-55-3
| PubChem=6437357
| ChemSpiderID = 4941921
| SMILES = C[C@H]([C@H](/C=C/c1csc(n1)c2csc(n2)C(C)/C=C/C=C/C(C)C)OC)/C(=C\\C(=O)N)/OC
| StdInChI = 1S/C25H33N3O3S2/c1-16(2)9-7-8-10-17(3)24-28-20(15-33-24)25-27-19(14-32-25)11-12-21(30-5)18(4)22(31-6)13-23(26)29/h7-18,21H,1-6H3,(H2,26,29)/b9-7+,10-8+,12-11+,22-13+/t17?,18-,21+/m1/s1
| StdInChIKey = XKTFQMCPGMTBMD-YCSHSZEBSA-N
| ChEBI = 25461
| MeSHName=Myxothiazol
|Section2={{Chembox Properties
| Formula=C₂₅H₃₃N₃O₃S₂
| MolarMass=487.68 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}

Myxothiazol (produced by the myxobacterium Myxococcus fulvus) is an inhibitor of the mitochondrial cytochrome bc1 complex (coenzyme Q - cytochrome c reductase).

Myxothiazol is a competitive inhibitor of ubiquinol, and binds at the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein. Binding of myxothiazol induces a red-shift to the visible absorption spectrum of reduced haem bl. In contrast to stigmatellin, myxothiazol does not form a hydrogen bond to the Rieske iron-sulfur protein, binding instead in the 'b-proximal' region of the cytochrome bQo site. Movement of the cytoplasmic domain of the Rieske protein is therefore unaffected by the binding of this inhibitor.{{Citation needed|reason=Citations needed for entire article, particularly regarding inhibitor binding sites.|date=March 2014}}

1 : Enzyme inhibitors

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