| 词条 | Dihydrotachysterol |
| 释义 |
| verifiedrevid = 460787840 | IUPAC_name = (1S,3E,4S)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylcyclohexan-1-ol | image = Dihydrotachysterol.png | alt = Structural formula | image2 = Dihydrotachysterol molecule spacefill.png | alt2 = Space-filling model of the dihydrotachysterol molecule | width = 190 | tradename = | Drugs.com = {{drugs.com|CONS|dihydrotachysterol}} | MedlinePlus = a682335 | pregnancy_AU = | pregnancy_US = | legal_AU = | legal_UK = | legal_US = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 67-96-9 | ATC_prefix = A11 | ATC_suffix = CC02 | PubChem = 5311071 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB01070 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4470607 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = R5LM3H112R | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D00299 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 4591 | C=28 | H=46 | O=1 | molecular_weight = 398.664 g/mol | smiles = O[C@@H]3C/C(=C\\C=C1/CCC[C@]2([C@H]1CC[C@@H]2[C@@H](/C=C/[C@H](C)C(C)C)C)C)[C@@H](C)CC3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-22,25-27,29H,7-8,11,14-18H2,1-6H3/b10-9+,23-12+,24-13+/t20-,21-,22+,25-,26+,27-,28+/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ILYCWAKSDCYMBB-OPCMSESCSA-N }}Dihydrotachysterol (DHT) is a synthetic vitamin D analog activated in the liver that does not require renal hydroxylation like vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). DHT has a rapid onset of action (2 hours), a shorter half-life, and a greater effect on mineralization of bone salts than does vitamin D.[1] References1. ^{{cite journal |title = Comparison of Dihydrotachysterol and 5,6-trans Vitamin D3 on Intestinal Calcium Absorption in Patients with Chronic Renal Failure |author1=R. Gagnon |author2=G. W. Ogden |author3=G. Just |author4=M. Kaye |journal = Canadian Journal of Physiology and Pharmacology |year = 1974 |volume = 52 |pages = 272–274 |doi = 10.1139/y74-037 |url = http://www.nrcresearchpress.com/doi/abs/10.1139/y74-037#.ULLSZdecnic |issue = 2 |pmid = 4365509}} {{Sterols}}{{Vitamins}}{{Vitamin D receptor modulators}}{{gastrointestinal-drug-stub}} 3 : Secosteroids|Vitamin D|Indanes |
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