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词条 Dilated cardiomyopathy
释义

  1. Signs and symptoms

  2. Causes

     Genetics 

  3. Pathophysiology

      Compensation effects   Computational models   Valvular effects  

  4. Diagnosis

  5. Treatment

      Medical therapy    Electrical treatment    Surgical treatment  

  6. Epidemiology

  7. Research directions

  8. References

  9. External links

{{Infobox medical condition (new)
| name = Dilated cardiomyopathy
| image = Myocardiopathy dilated2.JPG
| caption = Mouse heart slice showing dilated cardiomyopathy
| field = Cardiology
| synonyms = Congestive cardiomyopathy,
idiopathic cardiomyopathy,
primary cardiomyopathy[1]
| symptoms = Feeling tired, leg swelling, shortness of breath, chest pain, fainting[2]
| complications = Heart failure, heart valve disease, irregular heartbeat[3][4]
| onset = Middle age[5]
| duration =
| types = Tachycardia-induced,[2][7] others
| causes = Genetics, alcohol, cocaine, certain toxins, complications of pregnancy, certain infections[8][9][7]
| risks =
| diagnosis = Supported by electrocardiogram, chest X-ray, echocardiogram[9]
| differential = Coronary artery disease, heart valve disease, pulmonary embolism, other cardiomyopathy[5]
| prevention =
| treatment = Lifestyle changes, medications, implantable cardioverter defibrillator, heart transplant[9]
| medication = ACE inhibitor, beta blocker, diuretic, blood thinners[9]
| prognosis = Five-year survival rate ~50%[9]
| frequency = 1 in 2,500[9]
| deaths =
}}Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively.[3] Symptoms vary from none to feeling tired, leg swelling, and shortness of breath.[2] It may also result in chest pain or fainting.[4] Complications can include heart failure, heart valve disease, or an irregular heartbeat.[3][5]

Causes include genetics, alcohol, cocaine, certain toxins, complications of pregnancy, and certain infections.[8][9] Coronary artery disease and high blood pressure may play a role, but are not the primary cause.[8][6] In many cases the cause remains unclear.[7] It is a type of cardiomyopathy, a group of diseases that primarily affects the heart muscle.[3] The diagnosis may be supported by an electrocardiogram, chest X-ray, or echocardiogram.[9]

In those with heart failure, treatment may include medications in the ACE inhibitor, beta blocker, and diuretic families.[9] A low salt diet may also be helpful.[6] In those with certain types of irregular heartbeat, blood thinners or an implantable cardioverter defibrillator may be recommended.[9] If other measures are not effective a heart transplant may be an option in some.[9]

About 1 per 2,500 people are affected.[8] It occurs more frequently in men than women.[9] Onset is most often in middle age.[6] Five-year survival rate is about 50%.[8] It can also occur in children and is the most common type of cardiomyopathy in this age group.[8]

Signs and symptoms

{{Main|Heart failure#Signs and symptoms}}

Dilated cardiomyopathy develops insidiously, and may not initially cause symptoms significant enough to impact on quality of life.[10][11] Nevertheless, many people experience significant symptoms. These might include:

  • Shortness of breath
  • Syncope (fainting)
  • Angina, but only in the presence of ischemic heart disease

A person suffering from dilated cardiomyopathy may have an enlarged heart, with pulmonary edema and an elevated jugular venous pressure and a low pulse pressure. Signs of mitral and tricuspid regurgitation may be present.[11]

Causes

Although in many cases no cause is apparent, dilated cardiomyopathy is probably the result of damage to the myocardium produced by a variety of toxic, metabolic, or infectious agents. It may be due to fibrous change of the myocardium from a previous myocardial infarction. Or, it may be the late sequelae of acute viral myocarditis, such as with Coxsackie B virus and other enteroviruses[12] possibly mediated through an immunologic mechanism.[13]

Other causes include:

  • Chagas disease, due to Trypanosoma cruzi. This is the most common infectious cause of dilated cardiomyopathy in Latin America[14]
  • Pregnancy. Dilated cardiomyopathy occurs late in gestation or several weeks to months postpartum as a peripartum cardiomyopathy.[12] It is reversible in half of cases.[12]
  • Alcohol abuse (alcoholic cardiomyopathy)[12]
  • Nonalcoholic toxic insults include administration of certain chemotherapeutic agents, in particular doxorubicin (Adriamycin), and cobalt.[12]
  • Thyroid disease[11]
  • Inflammatory diseases such as sarcoidosis and connective tissue diseases[11]
  • Tachycardia-induced cardiomyopathy[15]
  • Muscular dystrophy
  • Tuberculosis - 1 to 2% of TB cases.[16]
  • Autoimmune mechanisms[17]
  • Thiamine deficiency

Recent studies have shown that those subjects with an extremely high occurrence (several thousands a day) of premature ventricular contractions (extrasystole) can develop dilated cardiomyopathy. In these cases, if the extrasystole are reduced or removed (for example, via ablation therapy) the cardiomyopathy usually regresses.[18][19]

Genetics

About 25–35% of affected individuals have familial forms of the disease,[12] with most mutations affecting genes encoding cytoskeletal proteins,[12] while some affect other proteins involved in contraction.[20] The disease is genetically heterogeneous, but the most common form of its transmission is an autosomal dominant pattern.[12]

Autosomal recessive (as found, for example, in Alström syndrome[12]), X-linked (as in Duchenne muscular dystrophy), and mitochondrial inheritance of the disease is also found.[21] Some relatives of those affected by dilated cardiomyopathy have preclinical, asymptomatic heart-muscle changes.[22]

Other cytoskeletal proteins involved in DCM include α-cardiac actin, desmin, and the nuclear lamins A and C.[12] Mitochondrial deletions and mutations presumably cause DCM by altering myocardial ATP generation.[12]

Kayvanpour et al. performed 2016 a meta-analysis with the largest dataset available on genotype-phenotype associations in DCM and mutations in lamin (LMNA), phospholamban (PLN), RNA Binding Motif Protein 20 (RBM20), Cardiac Myosin Binding Protein C (MYBPC3), Myosin Heavy Chain 7 (MYH7), Cardiac Troponin T 2 (TNNT2), and Cardiac Troponin I (TNNI3). They also reviewed recent studies investigating genotype-phenotype associations in DCM patients with titin (TTN) mutations. LMNA and PLN mutation carriers showed a high prevalence of cardiac transplantation and ventricular arrhythmia. Dysrhythmias and sudden cardiac death (SCD) was shown to occur even before the manifestation of DCM and heart failure symptoms in LMNA mutation carriers.[23]

Pathophysiology

The progression of heart failure is associated with left ventricular remodeling, which manifests as gradual increases in left ventricular end-diastolic and end-systolic volumes, wall thinning, and a change in chamber geometry to a more spherical, less elongated shape. This process is usually associated with a continuous decline in ejection fraction. The concept of cardiac remodeling was initially developed to describe changes that occur in the days and months following myocardial infarction.[24]

Compensation effects

As DCM progresses, two compensatory mechanisms are activated in response to impaired myocyte contractility and reduced stroke volume:[11]

  • Frank-Starling law
  • Neurohormonal feedback, via activation of the sympathetic nervous system and the renin-angiotensin system.

These responses initially compensate for decreased cardiac output and maintain those with DCM as asymptomatic. Eventually, however, these mechanisms become detrimental, intravascular volume becomes too great, and progressive dilatation leads to heart failure symptoms.

Computational models

Cardiac dilatation is a transversely isotropic, irreversible process resulting from excess strains on the myocardium.[25] A computation model of volumetric, isotropic, and cardiac wall growth predicts the relationship between cardiac strains (e.g. volume overload after myocardial infarction) and dilation using the following governing equations:

where is elastic volume stretch that is reversible and is irreversible, isotropic volume growth described by:

where is a vector, which points along a cardiomyocyte's long axis and is the cardiomyocyte stretch due to growth. The total cardiomyocyte growth is given by:

The above model reveals a gradual dilation of the myocardium, especially the ventricular myocardium, to support the blood volume overload in the chambers. Dilation manifests itself in an increase in total cardiac mass and cardiac diameter. Cardiomyocytes reach their maximum length of 150 m in the endocardium and 130 m in the epicardium by the addition of sarcomeres.[26] Due to the increase in diameter, the dilated heart appears spherical in shape, as opposed the elliptical shape of a healthy human heart. In addition, the ventricular walls maintain the same thickness, characteristic of pathophysiological cardiac dilation.

Valvular effects

As the ventricles enlarge, both the mitral and tricuspid valves may lose their ability to come together properly. This loss of coaptation may lead to mitral and tricuspid regurgitation. As a result, those with DCM are at increased risk of atrial fibrillation. Furthermore, stroke volume is decreased and a greater volume load is placed on the ventricle, thus increasing heart failure symptoms.[11]

Diagnosis

Generalized enlargement of the heart is seen upon normal chest X-ray. Pleural effusion may also be noticed, which is due to pulmonary venous hypertension.

The electrocardiogram often shows sinus tachycardia or atrial fibrillation, ventricular arrhythmias, left atrial enlargement, and sometimes intraventricular conduction defects and low voltage. When left bundle-branch block (LBBB) is accompanied by right axis deviation (RAD), the rare combination is considered to be highly suggestive of dilated or congestive cardiomyopathy.[27][28] Echocardiogram shows left ventricular dilatation with normal or thinned walls and reduced ejection fraction. Cardiac catheterization and coronary angiography are often performed to exclude ischemic heart disease.

Genetic testing can be important, since one study has shown that gene mutations in the TTN gene (which codes for a protein called titin) are responsible for "approximately 25% of familial cases of idiopathic dilated cardiomyopathy and 18% of sporadic cases."[29] The results of the genetic testing can help the doctors and patients understand the underlying cause of the dilated cardiomyopathy. Genetic test results can also help guide decisions on whether a patient's relatives should undergo genetic testing (to see if they have the same genetic mutation) and cardiac testing to screen for early findings of dilated cardiomyopathy.

Cardiac magnetic resonance imaging (cardiac MRI) may also provide helpful diagnostic information in patients with dilated cardiomyopathy.[30]

Treatment

Medical therapy

Drug therapy can slow down progression and in some cases even improve the heart condition. Standard therapy may include salt restriction, ACE inhibitors, diuretics, and beta blockers.[11] Anticoagulants may also be used for antithrombotic therapy. There is some evidence for the benefits of coenzyme Q10 in treating heart failure.[31][32][33]

Electrical treatment

Artificial pacemakers may be used in patients with intraventricular conduction delay, and implantable cardioverter-defibrillators in those at risk of arrhythmia. These forms of treatment have been shown to prevent sudden cardiac death, improve symptoms, and reduce hospitalization in patients with systolic heart failure.[34]

Surgical treatment

In patients with advanced disease who are refractory to medical therapy, heart transplantation may be considered. For these people 1-year survival approaches 90% and over 50% survive greater than 20 years.[34]

Epidemiology

Although the disease is more common in African-Americans than in Caucasians,[35] it may occur in any patient population.

Research directions

Therapies that support reverse remodeling have been investigated, and this may suggests a new approach to the prognosis of cardiomyopathies (see ventricular remodeling).[36][24]

==Other animals==

Dilated cardiomyopathy is a heritable disease in some dog breeds, including the Boxer, Dobermann, Great Dane, Irish Wolfhound, and St Bernard.[37] Treatment is based on medication, including ACE inhibitors, loop diuretics, and phosphodiesterase inhibitors.

Dilated cardiomyopathy is also a disease affecting some cat breeds, including the Oriental Shorthair, Burmese, Persian, and Abyssinian. In cats, taurine deficiency is the most common cause of dilated cardiomyopathy.[38] As opposed to these hereditary forms, non-hereditary DCM used to be common in the overall cat population before the addition of taurine to commercial cat food.

There is also a high incidence of heritable dilated cardiomyopathy in captive Golden Hamsters (Mesocricetus auratus), due in no small part to their being highly inbred. The incidence is high enough that several strains of Golden Hamster have been developed to serve as animal models in clinical testing for human forms of the disease.[39]

References

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2. ^{{cite web | title=Tachycardia-induced cardiomyopathy | website=European Society of Cardiology | date=2019-03-29 | url=https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-7/Tachycardia-induced-cardiomyopathy | access-date=2019-03-29 | quote=Tachycardia-induced cardiomyopathy is a reversible cause of heart failure and dilated cardiomyopathy. Tachycardia-induced cardiomyopathy should be considered in all patients with a dilated cardiomyopathy of uncertain origin and who have tachycardia or atrial fibrillation with a fast ventricular rate. }}
3. ^1 2 3 {{cite web|title=What Is Cardiomyopathy?|url=https://www.nhlbi.nih.gov/health/health-topics/topics/cm|website=NHLBI|accessdate=10 November 2017|language=en|date=22 June 2016}}
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5. ^1 {{cite web|title=Types of Cardiomyopathy|url=https://www.nhlbi.nih.gov/health/health-topics/topics/cm/types|website=NHLBI|accessdate=10 November 2017|language=en|date=22 June 2016}}
6. ^1 2 3 4 {{cite book|last1=Ferri|first1=Fred F.|title=Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1|date=2017|publisher=Elsevier Health Sciences|isbn=9780323529570|page=244|url=https://books.google.ca/books?id=wGclDwAAQBAJ&pg=PA244|language=en}}
7. ^1 2 3 {{cite web|title=What Causes Cardiomyopathy?|url=https://www.nhlbi.nih.gov/health/health-topics/topics/cm/causes|website=NHLBI|accessdate=10 November 2017|language=en|date=22 June 2016}}
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13. ^{{cite journal |vauthors=Martino TA, Liu P, Sole MJ |title=Viral infection and the pathogenesis of dilated cardiomyopathy |journal=Circ. Res. |volume=74 |issue=2 |pages=182–8 |date=February 1994 |pmid=8293557 |doi=10.1161/01.res.74.2.182}}
14. ^http://www.merckmanuals.com/professional/cardiovascular_disorders/cardiomyopathies/dilated_cardiomyopathy.html
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16. ^Ritesh Agarwal, corresponding author Puneet Malhotra, Anshu Awasthi, Nandita Kakkar, and Dheeraj Gupta. Tuberculous dilated cardiomyopathy: an under-recognized entity?" BMC Infect Dis 2005; 5: 29.Published online 2005 Apr 27. {{DOI|10.1186/1471-2334-5-29}}
17. ^{{cite journal|date=May 2002|title=[Dilated cardiomyopathy and autoimmunity: an overview of current knowledge and perspectives]|url=http://www.revespcardiol.org/cgi-bin/wdbcgi.exe/cardio/mrevista_cardio.pubmed_full?inctrl=05ZI0113&vol=55&num=5&pag=514|deadurl=yes|journal=Rev Esp Cardiol.|language=Spanish|volume=55|issue=5|pages=514–24|doi=10.1016/s0300-8932(02)76644-x|pmid=12015932|archiveurl=https://web.archive.org/web/20090109123423/http://www.revespcardiol.org/cgi-bin/wdbcgi.exe/cardio/mrevista_cardio.pubmed_full?inctrl=05ZI0113&vol=55&num=5&pag=514|archivedate=2009-01-09|vauthors=San Martín MA, García A, Rodríguez FJ, Terol I|df=}}
18. ^{{cite journal |author=Belhassen B |title=Radiofrequency ablation of "benign" right ventricular outflow tract extrasystoles: a therapy that has found its disease? |journal=J. Am. Coll. Cardiol. |volume=45 |issue=8 |pages=1266–8 |date=April 2005 |pmid=15837260 |doi=10.1016/j.jacc.2005.01.028 |url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(05)00234-2}}
19. ^{{cite journal |vauthors=Shiraishi H, Ishibashi K, Urao N, etal |title=A case of cardiomyopathy induced by premature ventricular complexes |journal=Circ. J. |volume=66 |issue=11 |pages=1065–7 |date=November 2002 |pmid=12419942 |url=http://joi.jlc.jst.go.jp/JST.JSTAGE/circj/66.1065?from=PubMed |doi=10.1253/circj.66.1065}}
20. ^{{cite journal |author=Ross J |title=Dilated cardiomyopathy: concepts derived from gene deficient and transgenic animal models |journal=Circ. J.|volume=66 |issue=3 |pages=219–24 |date=March 2002 |pmid=11922267 |url=http://joi.jlc.jst.go.jp/JST.JSTAGE/circj/66.219?from=PubMed |doi=10.1253/circj.66.219 }}
21. ^{{cite journal |vauthors=Schönberger J, Seidman CE |title=Many roads lead to a broken heart: the genetics of dilated cardiomyopathy |journal=American Journal of Human Genetics |volume=69 |issue=2 |pages=249–60 |date=August 2001 |pmid=11443548 |pmc=1235300 |doi=10.1086/321978 }}
22. ^{{cite journal |vauthors=Mahon NG, Murphy RT, MacRae CA, Caforio AL, Elliott PM, McKenna WJ |title=Echocardiographic evaluation in asymptomatic relatives of patients with dilated cardiomyopathy reveals preclinical disease |journal=Annals of Internal Medicine |volume=143 |issue=2 |pages=108–15 |date=July 2005 |pmid=16027452 |doi=10.7326/0003-4819-143-2-200507190-00009}}
23. ^{{cite journal|last1=Kayvanpour|first1=Elham|last2=Sedaghat-Hamedani|first2=Farbod|last3=Amr|first3=Ali|last4=Lai|first4=Alan|last5=Haas|first5=Jaan|last6=Holzer|first6=Daniel B.|last7=Frese|first7=Karen S.|last8=Keller|first8=Andreas|last9=Jensen|first9=Katrin|last10=Katus|first10=Hugo A.|last11=Meder|first11=Benjamin |title=Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals |journal=Clinical Research in Cardiology|date=2016-08-30|doi=10.1007/s00392-016-1033-6|pmid=27576561}}
24. ^1 {{cite journal |author=Pieske B |title=Reverse remodeling in heart failure – fact or fiction? |journal=Eur Heart J Suppl |volume=6 |pages=D66–78 |year=2004 |url=http://eurheartjsupp.oxfordjournals.org/cgi/content/abstract/6/suppl_D/D66 |doi=10.1016/j.ehjsup.2004.05.019}}
25. ^{{cite journal |doi=10.1016/j.jmps.2010.07.003 |title=Generic approach towards finite growth with examples of athlete's heart, cardiac dilation, and cardiac wall thickening |year=2010 |last1=Goektepe |first1=Serdar |last2=Abilez |first2=Oscar John |last3=Kuhl |first3=Ellen |journal=Mechanics and Physics of Solids |volume=58 |pages=1661–1680}}
26. ^{{cite journal |doi=10.1016/j.jmps.2010.07.003 |title=A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. |year=2010 |last1=Goektepe |first1=Serdar |last2=Abilez |first2=Oscar John |last3=Parker |first3=K |last4=Kuhl |first4=Ellen |journal=Theoretical Biology |volume=58 |pages=1661–1680}}
27. ^{{cite journal |vauthors=Nikolic G, Marriott HJ |title=Left bundle branch block with right axis deviation: a marker of congestive cardiomyopathy|journal=J Electrocardiol |volume=18 |issue=4 |pages=395–404|date=Oct 1985 |pmid=3906012 |doi=10.1016/s0022-0736(85)80022-4}}
28. ^{{cite journal |vauthors=Childers R, Lupovich S, Sochanski M, Konarzewska H |title=Left bundle branch block and right axis deviation: a report of 36 cases|journal=J Electrocardiol |volume=33 |issue=Suppl |pages=93–102|year=2000 |pmid=11265743 |doi=10.1054/jclc.2000.20326}}
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34. ^1 {{Cite book|url=https://www.worldcat.org/oclc/957316517|title=Current medical diagnosis & treatment 2017|others=Papadakis, Maxine A.,, McPhee, Stephen J.,, Rabow, Michael W.,|isbn=1259585115|edition=Fifty-sixth|location=New York|oclc=957316517}}
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37. ^{{cite journal |vauthors=Oyama MA, Chittur S |title=Genomic expression patterns of cardiac tissues from dogs with dilated cardiomyopathy |journal=Am J Vet Res |volume=66 |issue=7 |pages=1140–55 |date=July 2005 |pmid=16111151 |doi=10.2460/ajvr.2005.66.1140 }}
38. ^{{Cite journal|last=Pion|first=P. D.|last2=Kittleson|first2=M. D.|last3=Thomas|first3=W. P.|last4=Skiles|first4=M. L.|last5=Rogers|first5=Q. R.|date=1992-07-15|title=Clinical findings in cats with dilated cardiomyopathy and relationship of findings to taurine deficiency|journal=Journal of the American Veterinary Medical Association|volume=201|issue=2|pages=267–274|issn=0003-1488|pmid=1500323}}
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External links

{{Medical resources
|geneReviewsNBK2= NBK1119
|geneReviewsName2= Dystrophinopathies
| DiseasesDB = 3066
| ICD10 = {{ICD10|I|42|0|i|30}}
| ICD9 = {{ICD9|425.4}}
| ICDO =
| OMIM = 212110
| MedlinePlus = 000168
| eMedicineSubj = med
| eMedicineTopic = 289
| eMedicine_mult = {{eMedicine2|emerg|80}} {{eMedicine2|ped|2502}}
| MeshID = D002311
| GeneReviewsNBK = NBK1309
| GeneReviewsName = Dilated Cardiomyopathy Overview
}}
  • Cardiomyopathy - Stanford Children's Health
  • [https://web.archive.org/web/20061006052407/http://www.cardiomyopathy.org/html/which_card_dcm.htm Cardiomyopathy Association: Dilated cardiomyopathy]
  • Children's Cardiomyopathy Foundation
  • Dilated cardiomyopathy information for parents.
{{Circulatory system pathology}}{{Cytoskeletal defects}}{{ABC transporter disorders}}

4 : Cardiomyopathy|Cytoskeletal defects|Cardiogenetic disorders|RTT
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