| 词条 | Nabil Seidah |
| 释义 |
| name = Nabil Seidah | honorific_suffix = {{post-nominals|country=CAN|size=100%|CM|CQ|FRSC}} | image = | image_size = | alt = | caption = | birth_date = 1949 | birth_place = Egypt | death_date = | death_place = | resting_place = | resting_place_coordinates = | residence = | citizenship = | nationality = Canadian | fields = Biochemistry | workplaces = Clinical Research Institute of Montreal | alma_mater = Cairo University Georgetown University | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = Proprotein convertase, PCSK9 | author_abbrev_bot = | author_abbrev_zoo = | influences = | influenced = | awards = | signature = | signature_alt = | website = | footnotes = | spouse = }} Nabil G. Seidah, {{Post-nominals|country=CAN|CM|OQ|FRSC}} (born 1949) is a Canadian Québécois scientist. Born in Egypt, he was educated at Cairo University, and subsequently at Georgetown University where he obtained his Ph.D. in 1973.[1][2] He emigrated to Canada and has been working at the Clinical Research Institute of Montreal (IRCM) since 1974.[1] He is the director of the laboratory of Biochemical Neuroendocrinology.[1] He discovered and cloned seven (PC1, PC2, PC4, PC5, PC7, SKI-1 and PCSK9) of the nine known enzymes belonging to the convertase family. During this period, he also greatly contributed to demonstrating that the proteolysis by the proprotein convertases is a wide mechanism that also concerns “non-neuropeptide” proteins such as growth factors, α-integrins, receptors, enzymes, membrane-bound transcription factors, and bacterial and viral proteins. Recently, he showed that point mutations in the PCSK9 gene cause dominant familial hypercholesterolemia, likely because of a gain of function related to the ability of PCSK9 to enhance the degradation of cell surface receptors, such as the low-density lipoprotein receptor. Awards
References1. ^1 2 3 4 {{Cite web |url= http://www.icav-citav.ca/viral_global_threat/bios/nabil_seidah.php |title=Nabil G. Seidah |work=International Consortium on Anti-Virals |accessdate=26 December 2010}} {{DEFAULTSORT:Seidah, Nabil}}{{Canada-scientist-stub}}2. ^1 {{Cite web |url= http://www.ircm.qc.ca/microsites/Nseidah/en/ |title=Director's biography |work=Clinical Research Institute of Montreal |accessdate=26 December 2010}} 3. ^{{Cite web |url= http://archive.gg.ca/honours/search-recherche/honours-desc.asp?lang=e&TypeID=orc&id=3942 |title=Nabil G. Seidah, C.M., O.Q., Ph.D. |work=Governor General of Canada |accessdate=26 December 2010}} 4. ^1 {{Cite web |url= http://www.rsc.ca/awards_The_McLaughlin_Medal_winner.php#TOC6 |title= Nabil G. Seidah, FRSC |work=Royal Society of Canada |accessdate=26 December 2010}} 13 : 1949 births|Living people|Scientists from Montreal|Egyptian scientists|Egyptian chemists|Fellows of the Royal Society of Canada|Members of the Order of Canada|Officers of the National Order of Quebec|Cairo University alumni|Georgetown University alumni|Canadian biochemists|20th-century Canadian scientists|21st-century Canadian scientists |
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