“N-acetylornithine carbamoyltransferase”的意思、由来-开放百科全书

词条

N-acetylornithine carbamoyltransferase

释义

Structural studies
References

{{enzyme
| Name = N-acetylornithine carbamoyltransferase
| EC_number = 2.1.3.9
| CAS_number = 890853-54-0
| IUBMB_EC_number = 2/1/3/9
| GO_code = 0043857
| image =
| width =
| caption =
}}

In enzymology, a N-acetylornithine carbamoyltransferase ({{EC number|2.1.3.9}}) is an enzyme that catalyzes the chemical reaction

carbamoyl phosphate + N₂-acetyl-L-ornithine phosphate + N-acetyl-L-citrulline

Thus, the two substrates of this enzyme are carbamoyl phosphate and N2-acetyl-L-ornithine, whereas its two products are phosphate and N-acetyl-L-citrulline.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases. The systematic name of this enzyme class is carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase. Other names in common use include acetylornithine transcarbamylase, N-acetylornithine transcarbamylase, AOTC, and carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2G65}}, {{PDB link|2G68}}, {{PDB link|2G6A}}, and {{PDB link|2G6C}}.

References

{{cite journal | vauthors = Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M | title = Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria | journal = The Journal of Biological Chemistry | volume = 280 | issue = 15 | pages = 14366–9 | date = April 2005 | pmid = 15731101 | doi = 10.1074/jbc.C500005200 }}

2 : EC 2.1.3|Enzymes of known structure

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