“NADPH:quinone reductase”的意思、由来-开放百科全书

词条

NADPH:quinone reductase

释义

Structural studies
References

{{enzyme
| Name = NADPH:quinone reductase
| EC_number = 1.6.5.5
| CAS_number = 9032-20-6
| IUBMB_EC_number = 1/6/5/5
| GO_code = 0003960
| image =
| width =
| caption =
}}

In enzymology, a NADPH:quinone reductase ({{EC number|1.6.5.5}}) is an enzyme that catalyzes the chemical reaction

NADPH + H⁺ + 2quinone NADP⁺ + 2semiquinone

The 3 substrates of this enzyme are NADPH, H⁺, and quinone, whereas its two products are NADP⁺ and semiquinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NADPH:quinone oxidoreductase. This enzyme is also called NADPH2:quinone reductase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1IYZ}}, {{PDB link|1IZ0}}, and {{PDB link|1YB5}}.

References

{{cite journal | vauthors = Rao PV, Krishna CM, ((Zigler JS Jr)) | date = 1992 | title = Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase | journal = J. Biol. Chem. | volume = 267 | pages = 96–102 | pmid = 1370456 | issue = 1 }}

3 : EC 1.6.5|NADPH-dependent enzymes|Enzymes of known structure

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