请输入您要查询的百科知识：

　

词条 NALP3
释义

  1. Nomenclature

  2. Structure

  3. Function

  4. Pathology

  5. References and notes

{{Infobox_gene}}NACHT, LRR and PYD domains-containing protein 3 (NALP3), also known as cryopyrin, is a protein that in humans is encoded by the NLRP3 gene[1] located on the long arm of chromosome 1.[2]

NALP3 is expressed predominantly in macrophages and as a component of the inflammasome,[3][4]{{rp|436}} detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NALP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases.

Nomenclature

NACHT, LRR, and PYD are respectively acronyms for:

  • NACHT – NAIP (neuronal apoptosis inhibitor protein), C2TA [class 2 transcription activator, of the MHC, HET-E (heterokaryon incompatibility) and TP1 (telomerase-associated protein 1)
  • LRR – "leucine-rich repeat" [5][6] and is synonymous with NLR, for or nucleotide-binding domain, leucine-rich repeat"[7]
  • PYD – "PYRIN domain," after the pyrin proteins[8] The NLRP3 gene name abbreviates "NLR family, pyrin domain containing 3," where NLR refers to "nucleotide-binding domain, leucine-rich repeat."[9]

The NACHT, LRR and PYD domains-containing protein 3 is also called:

  • cold induced autoinflammatory syndrome 1 (CIAS1),
  • caterpiller-like receptor 1.1 (CLR1.1), and
  • PYRIN-containing APAF1-like protein 1 (PYPAF1).[10]

Structure

This gene encodes a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with pyrin domain (PYD) of apoptosis-associated speck-like protein containing a CARD (ASC). Proteins which contain the caspase recruitment domain, CARD, have been shown to be involved in inflammation and immune response.[1]

Function

NALP3 is a component of the innate immune system that functions as a pathogen recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs).[12] NALP3 belongs to the NOD-like receptor (NLR) subfamily of PRRs and NALP3 together with the adaptor ASC protein PYCARD forms a caspase-1 activating complex known as the NALP3 inflammasome. NALP3 in the absence of activating signal is kept in an inactive state complexed with HSP90 and SGT1 in the cytoplasm. NALP3 inflammasome detects danger signals such as crystalline uric acid and extracellular ATP released by damaged cells. These signals release HSP90 and SGT1 from and recruit ASC protein and caspase-1 to the inflammasome complex. Caspase-1 within the activated NALP3 inflammasome complex in turn activates the inflammatory cytokine, IL-1β.[11]

The NALP3 inflammasome appears to be activated by changes in intracellular potassium caused by potassium efflux from mechanosensitive ion channels located in the cell membrane.[12] It appears that NALP3 is also regulated by reactive oxygen species (ROS), though the precise mechanisms of such regulation has not been determined.[13]

Pathology

Mutations in the NLRP3 gene have been associated with a spectrum of dominantly inherited autoinflammatory diseases called cryopyrin-associated periodic syndrome (CAPS). This includes familial cold autoinflammatory syndrome (FCAS), Muckle–Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal onset multisystem inflammatory disease (NOMID), and keratoendotheliitis fugax hereditaria.[1][14]

Defects in this gene have also been linked to familial Mediterranean fever.[15] In addition, the NALP3 inflammasome has a role in the pathogenesis of gout[11] and neuroinflammation occurring in protein-misfolding diseases, such as Alzheimer's, Parkinson's, and prion diseases.[16][17][18] Amelioration of mouse models of many diseases has been shown to occur by deletion of the NLRP3 inflammasome, including gout, type 2 diabetes, multiple sclerosis, Alzheimer's disease, and atherosclerosis.[19] The ketone β-Hydroxybutyrate has been shown to block NLRP3 activation, and thus may be of benefit for many of these diseases.[20]

Deregulation of NALP3 has been connected with carcinogenesis. For example, all the components of the NALP3 inflammasome are downregulated or completely lost in human hepatocellular carcinoma.[21]

{{clear}}

References and notes

1. ^1 2 {{cite web | author = Anon. | date = 2015 | title = Entrez Gene: NLRP3 NLR family, pyrin domain containing 3 [Homo sapiens (human)], Gene ID: 114548 (updated on 13-Nov-2015) | location = Bethesda, MD, USA | publisher = National Center for Biotechnology Information, National Library of Medicine | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114548 | access-date=13 November 2015}}
2. ^{{cite journal | vauthors = Hoffman HM, Wright FA, Broide DH, Wanderer AA, Kolodner RD | title = Identification of a locus on chromosome 1q44 for familial cold urticaria | journal = American Journal of Human Genetics | volume = 66 | issue = 5 | pages = 1693–8 | date = May 2000 | pmid = 10741953 | pmc = 1378006 | doi = 10.1086/302874 }}
3. ^{{cite journal | vauthors = Tao JH, Zhang Y, Li XP | title = P2X7R: a potential key regulator of acute gouty arthritis | journal = Seminars in Arthritis and Rheumatism | volume = 43 | issue = 3 | pages = 376–80 | date = Dec 2013 | pmid = 23786870 | doi = 10.1016/j.semarthrit.2013.04.007 | department = review }}
4. ^{{cite journal | vauthors = Lu A, Wu H | title = Structural mechanisms of inflammasome assembly | journal = The FEBS Journal | volume = 282 | issue = 3 | pages = 435–44 | date = Feb 2015 | pmid = 25354325 | doi = 10.1111/febs.13133 | department = review }}
5. ^{{cite journal | vauthors = Koonin EV, Aravind L | title = The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation | journal = Trends in Biochemical Sciences | volume = 25 | issue = 5 | pages = 223–4 | date = May 2000 | pmid = 10782090 | doi = 10.1016/S0968-0004(00)01577-2 }}
6. ^{{cite journal | vauthors = Pueyo I, Jiménez JR, Hernández J, Brugarolas A, García-Morán M, García-Muñiz JL, Arroyo F | title = Carcinoid syndrome treated by hepatic embolization | journal = AJR. American Journal of Roentgenology | volume = 131 | issue = 3 | pages = 511–3 | date = Sep 1978 | pmid = 99001 | doi = 10.2214/ajr.131.3.511 }}
7. ^{{cite journal | vauthors = Jha S, Ting JP | title = Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases | journal = Journal of Immunology | volume = 183 | issue = 12 | pages = 7623–9 | date = Dec 2009 | pmid = 20007570 | pmc = 3666034| doi = 10.4049/jimmunol.0902425 }}
8. ^{{cite journal | vauthors = Bertin J, DiStefano PS | title = The PYRIN domain: a novel motif found in apoptosis and inflammation proteins | journal = Cell Death and Differentiation | volume = 7 | issue = 12 | pages = 1273–4 | date = Dec 2000 | pmid = 11270363 | pmc = | doi = 10.1038/sj.cdd.4400774 | department = review }}
9. ^{{cite journal | vauthors = Jha S, Ting JP | title = Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases | journal = Journal of Immunology | volume = 183 | issue = 12 | pages = 7623–9 | date = Dec 2009 | pmid = 20007570 | doi = 10.4049/jimmunol.0902425 | department = review | pmc=3666034}}
10. ^{{uniprot|Q96P20}}
11. ^1 2 {{cite journal | vauthors = Martinon F | title = Detection of immune danger signals by NALP3 | journal = Journal of Leukocyte Biology | volume = 83 | issue = 3 | pages = 507–11 | date = Mar 2008 | pmid = 17982111 | doi = 10.1189/jlb.0607362 | department = review }}
12. ^{{cite journal | vauthors = Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, Shi Y | title = Activation of NLRP3 inflammasome by crystalline structures via cell surface contact | journal = Scientific Reports | volume = 4 | year = 2014 | pmid = 25445147 | doi = 10.1038/srep07281 | pages=7281 | pmc=4250918}}
13. ^{{cite journal | vauthors = Haneklaus M, O'Neill LA, Coll RC | title = Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments | journal = Current Opinion in Immunology | volume = 25 | issue = 1 | pages = 40–45 | date = Feb 2013 | pmid = 23305783 | doi = 10.1016/j.coi.2012.12.004 | department = review }}
14. ^{{cite journal | vauthors = Turunen JA, Wedenoja J, Repo P, Järvinen RS, Jäntti JE, Mörtenhumer S, Riikonen AS, Lehesjoki AE, Majander A, Kivelä TT | title = Keratoendotheliitis Fugax Hereditaria: A Novel Cryopyrin-Associated Periodic Syndrome Caused by a Mutation in the Nucleotide-Binding Domain, Leucine-Rich Repeat Family, Pyrin Domain-Containing 3 (NLRP3) Gene | journal = American Journal of Ophthalmology | volume = 184 | issue = | pages = 41–50| date = Jan 2018 | pmid = 29366613 | doi = 10.1016/j.ajo.2018.01.017 }}
15. ^{{cite journal | vauthors = Church LD, Cook GP, McDermott MF | title = Primer: inflammasomes and interleukin 1beta in inflammatory disorders | journal = Nature Clinical Practice Rheumatology | volume = 4 | issue = 1 | pages = 34–42 | date = Jan 2008 | pmid = 18172447 | doi = 10.1038/ncprheum0681 | department = review }}
16. ^{{cite journal | vauthors = Liu-Bryan R | title = Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome | journal = Immunology and Cell Biology | volume = 88 | issue = 1 | pages = 20–3 | date = Jan 2010 | pmid = 19935768 | pmc = 4337950 | doi = 10.1038/icb.2009.93 | department = review }}
17. ^{{cite journal | vauthors = Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT | title = NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice | journal = Nature | volume = 493 | issue = 7434 | pages = 674–8 | date = Jan 2013 | pmid = 23254930 | pmc = 3812809 | doi = 10.1038/nature11729 }}
18. ^{{cite journal | vauthors = Shi F, Kouadir M, Yang Y | title = NALP3 inflammasome activation in protein misfolding diseases | journal = Life Sciences | volume = 135 | issue = | pages = 9–14 | date = Aug 2015 | pmid = 26037399 | doi = 10.1016/j.lfs.2015.05.011 | department = review }}
19. ^{{cite journal | vauthors=Levy M, Thaiss CA, Elinav E | title=Taming the inflammasome | journal= Nature Medicine | volume=21 | issue=3 | pages=213–215 | year=2015 | url=https://www.weizmann.ac.il/immunology/elinav/sites/immunology.elinav/files/nm_newsviews_2015.pdf | doi= 10.1038/nm.3808 | pmid = 25742454 }}
20. ^{{cite journal | vauthors=Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD | title=The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease | journal= Nature Medicine | volume=21 | issue=3 | pages=263–269 | year=2015 | doi= 10.1038/nm.3804| pmid = 25686106 | pmc=4352123 }}
21. ^{{cite journal | vauthors = Wei Q, Mu K, Li T, Zhang Y, Yang Z, Jia X, Zhao W, Huai W, Guo P, Han L | title = Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression | journal = Laboratory Investigation | volume = 94 | issue = 1 | pages = 52–62 | date = Jan 2014 | pmid = 24166187 | doi = 10.1038/labinvest.2013.126 }}
{{NOD-like receptors}}{{DEFAULTSORT:Nalp3}}

3 : LRR proteins|Human proteins|NOD-like receptors
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/21 17:48:36