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词条 Nancy Rothwell
释义

  1. Education

  2. Research

  3. Career

  4. Awards and honours

  5. References

  6. External links

{{Use dmy dates|date=February 2013}}{{Use British English|date=February 2013}}{{Infobox officeholder
| honorific_prefix = Dame
| name = Nancy Rothwell
| honorific_suffix = {{post-nominals|country=GBR|DBE|DL|FRS|FMedSci|FBPhS}}
| caption = Rothwell in academic dress for a graduation ceremony for the School of Mathematics at the University of Manchester in 2015
| image = Nancy_Rothwell_P1030027_(23707820741)_(cropped).jpg
|office = President and Vice Chancellor of the University of Manchester
|term_start = 21 June 2010
|term_end =
|predecessor = Alan Gilbert
|successor =
| birth_name = Nancy Jane Rothwell
| birth_date = {{Birth date and age|1955|10|2|df=y}}[1]
| birth_place = Tarleton, Lancashire, United Kingdom
| death_date =
| death_place =
| residence =
| citizenship =
| nationality = British
| alma_mater = University of London (BSc, PhD, DSc)[1]
| awards = {{Plainlist|
  • DBE (2005)
  • Deputy Lieutenant
  • FRS (2004)[3][4]
  • FRSB{{when|date=December 2016}}
  • FMedSci[1]
  • MAE[2]}}

| website = {{URL|manchester.ac.uk/research/nancy.rothwell}}
| spouse =
| module2 = {{Listen |embed= yes |filename= Prof_Dame_Nancy_Rothwell_BBC_Radio4_The_Life_Scientific_7_May_2013_b01s89mh.flac |title= Nancy Rothwell's voice |type= speech |description= from the BBC programme The Life Scientific, 2013-07-07[3]}}
| module =
| fields = {{Plainlist|
  • Obesity
  • Strokes
  • Metabolism
  • Neuroscience
  • Brown adipose tissue[8][4][5][11]}}

| workplaces = {{Plainlist|
  • University of Manchester
  • University of London
  • Queen Elizabeth College
  • AstraZeneca}}

| thesis_title = Physiological mechanisms involved in the regulation of energy balance
| thesis_url = http://catalogue.libraries.london.ac.uk/record=b3009685
| thesis_year = 1979
| doctoral_advisor = Mike J. Stock[8][11]
| academic_advisors =
| doctoral_students = (~50 in total)[6]
| notable_students =
| known_for = {{Plainlist|
  • Christmas Lecturer (1998)
  • Vice Chancellor of the University of Manchester
  • Research on Brown adipose tissue and Cytokines}}

| influences = Bridget Ogilvie[7]
Ian MacDonald[11][8]
Derek Miller[11]
| influenced =
}}Dame Nancy Jane Rothwell {{post-nominals|country=GBR|DBE|DL|FRS|FMedSci|FBPhS}} (born 2 October 1955)[9] is a British physiologist, President and Vice-Chancellor of the University of Manchester since July 2010,[10] having been Deputy President and Deputy Vice-Chancellor since January 2010. Rothwell is also a director of pharmaceuticals company AstraZeneca,[11] co-chair of the Council for Science and Technology and past President of the Royal Society of Biology.[12][13][14][15][16][17][18] She is a Deputy Lieutenant of Greater Manchester.[19]

Education

Rothwell was born in Tarleton, a village near Preston, Lancashire. She was educated at Penwortham Girls’ Grammar School and then went to college where she took four A-levels in maths, physics, chemistry and art.[11] She enrolled at the University of London and obtained a first class degree in physiology (1976) and a Doctor of Philosophy degree (1979)[20] from Queen Elizabeth College, now part of King's College, London.[21] Rothwell was later was awarded a Doctor of Science degree in 1987 by King's College London and an honorary Doctor of Law degree from the University of Bath in 2009.

Research

Rothwell's early research[22][23][24][25] identified mechanisms of energy balance regulation, obesity and cachexia.[26] In 1984 she was awarded a Royal Society Research Fellowship and relocated to Manchester in 1987 and numerous grants by the BBSRC.[27] She was appointed to a chair in physiology in 1994, then a Medical Research Council research chair in 1998. Her current research focusses on the role of inflammation in brain disease and has identified the role of the cytokine interleukin-1 (IL-1)[28] in diverse forms of brain injury.[29][30] Her studies have begun to elucidate the mechanisms regulating IL-1 release and its action and her group have conducted the first early clinical trial of an IL-1 inhibitor in strokes. She served as president of the British Neuroscience Association and a council member of Medical Research Council (MRC).{{when|date=November 2016}}

Career

From October 2004 Rothwell was vice-president for research of the University.[31][32] In 2010 she was overseeing a research group of about 20 scientists, with significant external funding and was announced to succeed Alan Gilbert as President and Vice-Chancellor of the University of Manchester on 1 July 2010. She is a trustee of Cancer Research UK, the Campaign for Medical Progress, a council member of BBSRC, chair of the Research Defence Society and the Wellcome Trust's Public Engagement Strategy Committee and a non-executive director of AstraZeneca. In 1998 she delivered the Royal Institution Christmas Lecture on The Secrets of Life, televised by the BBC.[33]

In January 2010, Rothwell was appointed deputy president and deputy vice-chancellor. Until Alan Gilbert retired she was acting president due to his sick leave. On 21 June 2010, she was appointed President and Vice-Chancellor of the University of Manchester. She assumed her post on 1 July 2010, succeeding Alan Gilbert, who had retired after nearly six years. She became the first woman to lead the University of Manchester or either of its two predecessor institutions. Commenting on her appointment, she said: "I am honoured and delighted to be invited to lead the University at this exciting time. I am determined to maintain the strategic focus that we have developed over the past six years and to work closely with colleagues to identify new priorities and opportunities for the University in the very challenging external environment that we will face over the next few years."{{citation needed|date=April 2014}}

The chairman of the appointment panel and chairman-elect of the university's board of governors, Anil Ruia, said: "Dame Nancy will bring her own distinctive strengths, perspective and style to the role of President and Vice-Chancellor which will enable the University to build upon the remarkable progress that we have made under Professor Alan Gilbert's leadership."{{citation needed|date=April 2014}} In 2009 Rothwell become the first president of the Society of Biology, now the Royal Society of Biology.

Rothwell is an honorary fellow of Somerville College, Oxford.

Awards and honours

In February 2013 she was assessed as the 15th most powerful woman in the United Kingdom by Woman's Hour on BBC Radio 4.[34][35] In May 2013 she was the subject of BBC Radio 4's The Life Scientific and was interviewed about her life and work by Jim Al-Khalili.[36] Rothwell was appointed Dame Commander of the Order of the British Empire (DBE) in the 2005 Birthday Honours,[37] Fellow of the Royal Society (FRS) in 2004,[38] Fellow of the Royal Society of Biology (FRSB) and Fellow of the Academy of Medical Sciences (FMedSci).{{when|date=December 2016}}[1] In 2003 she won the prestigious Royal Society Pfizer Award.[39][40] Her nomination for the Royal Society reads:[41]

{{quote|Nancy Rothwell has made major discoveries in the areas of energy balance, host defence responses, and neurodegeneration, several of which are now being translated into clinical benefit. Early work emphasised the importance of thermogenesis in the regulation of energy balance and the aetiology of obesity, and the role of b2 adrenoreceptor activation in muscle hypertrophy. More recently she has carried out pioneering studies of the role of cytokines and other components of the immune system within the central nervous system. She demonstrated the key role of specific cytokines and the hormone leptin in the integration and regulation by the brain of host defence responses to infection and injury. This led to important discoveries concerning the role of cytokines in neurodegeneration. She was the first to show that the cytokine IL-1 mediates ischaemic brain damage, challenging the view that immune or inflammatory processes are unimportant in the brain. She patented the use of IL-1 inhibitors to prevent acute neurodegeneration and is leading the first clinical trial of such an inhibitor in stroke. Her demonstration that caspases are involved directly in ischaemic brain damage in vivo stimulated the development of caspase inhibitors for possible clinical application. Nancy Rothwell has also worked energetically to advance physiology and neuroscience, to further public awareness of science, and to encourage women to pursue careers in science.}}

She is a honorary member of the British Society for Immunology.[42]

References

1. ^1 2 3 {{Who's Who | surname = ROTHWELL | othernames = Dame Nancy (Jane) | id = U43057 | volume = 2003 | edition = online Oxford University Press}} {{subscription required}}
2. ^{{cite web|url=http://www.ae-info.org/ae/User/Rothwell_Nancy |title=Academy of Europe: Rothwell Nancy |publisher=Ae-info.org |accessdate=2017-06-07}}
3. ^{{Cite episode |title= Nancy Rothwell |series= The Life Scientific |serieslink= The Life Scientific |url= http://bbc.co.uk/programmes/b01s89mh |station= BBC Radio 4 |date= 2013-05-07 |accessdate= 2014-01-18 }}
4. ^{{Cite journal | last1 = Selvarajah | first1 = J. | last2 = Scott | first2 = M. | last3 = Stivaros | first3 = S. | last4 = Hulme | first4 = S. | last5 = Georgiou | first5 = R. | last6 = Rothwell | first6 = N. | authorlink6 = Nancy Rothwell| last7 = Tyrrell | first7 = P. | last8 = Jackson | first8 = A. | doi = 10.1007/s00330-008-1202-8 | title = Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke | journal = European Radiology | volume = 19 | issue = 4 | pages = 1011–1018 | year = 2008 | pmid = 18987865 | pmc = }}
5. ^{{Cite journal | last1 = Selvarajah | first1 = J. R. | last2 = Smith | first2 = C. J. | last3 = Hulme | first3 = S. | last4 = Georgiou | first4 = R. | last5 = Sherrington | first5 = C. | last6 = Staniland | first6 = J. | last7 = Illingworth | first7 = K. J. | last8 = Jury | first8 = F. | last9 = Payton | first9 = A. | last10 = Ollier | doi = 10.1111/j.1747-4949.2010.00561.x | first10 = W. E. | last11 = Vail | first11 = A. | last12 = Rothwell | first12 = N. J. | last13 = Hopkins | first13 = S. J. | last14 = Tyrrell | first14 = P. J. | title = Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study | journal = International Journal of Stroke | volume = 6 | issue = 3 | pages = 187–194 | year = 2011 | pmid = 21557802 | pmc = }}
6. ^{{cite web|url=http://www.ae-info.org/attach/User/Rothwell_Nancy/rothwell_nancy_long_cv.pdf |title=CURRICULUM VITAE |website=www.ae-info.org |date=October 2009 |accessdate=2017-06-07}}
7. ^{{cite news|url=https://www.theguardian.com/women-in-leadership/2013/apr/23/dame-nancy-rothwell-break-the-rules |title=Dame Nancy Rothwell: 'Break the rules and see what happens' |work=The Guardian |first=Kate |last=McCann |date=23 April 2013 |df=dmy }}
8. ^{{Cite journal | last1 = MacDonald | first1 = I. A. | last2 = Rothwell | first2 = N. J. | authorlink2 = Nancy Rothwell | last3 = Stock | first3 = M. J. | title = Lipolytic and lipogenic activities of adipose tissue during spontaneous fat depletion and repletion proceedings | journal = The Proceedings of the Nutrition Society | volume = 35 | issue = 3 | pages = 129A–130A | year = 1976 | pmid = 1028061}}
9. ^Who's Who in Greater Manchester; golden jubilee edition. Manchester: Manchester Literary & Philosophical Society, 2002; p. 313
10. ^New President and Vice-Chancellor for the University of Manchester
11. ^{{cite news| url=https://people.forbes.com/profile/dame-nancy-rothwell/8087 | work=Forbes |title=Dame Rothwell}}
12. ^{{cite web|url=http://mancunion.com/2013/02/25/dame-nancy-rothwell-qa/ |title=As it happened: Q&A with Professor Dame Nancy Rothwell > The Mancunion |work= |archivedate=16 May 2013 |archiveurl=https://www.webcitation.org/6GennouIw?url=http://mancunion.com/2013/02/25/dame-nancy-rothwell-qa/ |deadurl=yes |df=dmy }}
13. ^Brown, Matthew (September 2004) "A Society Fellow", in: AUTlook. Association of University Teachers; no. 231, pp. 24-25.
14. ^{{cite web |url=http://www.newstatesman.com/education/2010/10/manchester-university-science |title=The New Statesman Interview: Nancy Rothwell, vice-chancellor, Manchester University |work= |accessdate=}}
15. ^{{cite web |url=https://societyofbiology.org/news/14-news/890-society-officially-welcomes-new-president?dm_i=I1,2HCXA,3A0LOU,9188G,1 |title=Society of Biology welcomes new President |work= |accessdate=}}
16. ^[https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Rothwell+N Peer-reviewed publications by Nancy Rothwell] (in PubMed)
17. ^{{Scopus|id=36042800200}}
18. ^[https://scholar.google.co.uk/scholar?q=nancy+rothwell Nancy Rothwell's publications in Google Scholar]
19. ^http://manchesterlieutenancy.org/Rothwell_Nancy
20. ^{{cite thesis|degree=PhD|first=Nancy Jane|last=Rothwell|title=Physiological mechanisms involved in the regulation of energy balance|publisher=Kings College London|date=1979|id={{EThOS|uk.bl.ethos.471044}}|authorlink=Nancy Rothwell|oclc=827269727|url=http://catalogue.libraries.london.ac.uk/record=b3009685|website=london.ac.uk}}
21. ^Nancy Rothwell {{ORCID|0000-0002-3325-3149}}
22. ^1 2 {{Cite journal | doi = 10.1038/281031a0 | last1 = Rothwell | first1 = N.| authorlink = Nancy Rothwell | last2 = Stock | first2 = M. | title = A role for brown adipose tissue in diet-induced thermogenesis | journal = Nature | volume = 281 | issue = 5726 | pages = 31–35 | year = 1979 | pmid = 551265}}
23. ^{{AcademicSearch|18102816}} {{dead link|date=December 2016}}
24. ^{{Cite journal | last1 = Hopkins | first1 = S. | last2 = Rothwell | first2 = N.| authorlink2 = Nancy Rothwell | title = Cytokines and the nervous system. I: Expression and recognition | journal = Trends in Neurosciences | volume = 18 | issue = 2 | pages = 83–88 | year = 1995 | pmid = 7537419 | doi=10.1016/0166-2236(95)93881-W}}
25. ^{{Cite journal | last1 = Rothwell | first1 = N.| authorlink1 = Nancy Rothwell | last2 = Hopkins | first2 = S. | title = Cytokines and the nervous system II: Actions and mechanisms of action | journal = Trends in Neurosciences | volume = 18 | issue = 3 | pages = 130–136 | year = 1995 | pmid = 7754524 | doi=10.1016/0166-2236(95)93890-A}}
26. ^{{Cite journal | doi = 10.1016/S0026-0495(97)90047-0 | last1 = Roe | first1 = S. Y. | last2 = Cooper | first2 = A. L. | last3 = Morris | first3 = I. D. | last4 = Rothwell | first4 = N. J.| authorlink4 = Nancy Rothwell| title = Involvement of prostaglandins in cachexia induced by T-cell leukemia in the rat | journal = Metabolism: clinical and experimental | volume = 46 | issue = 4 | pages = 359–365 | year = 1997 | pmid = 9109835}}
27. ^{{cite web |url=http://www.bbsrc.ac.uk/PA/grants/PersonDetails.aspx?Personid=13650 |title=Grants awarded to Nancy Rothwell by the BBSRC |work= |accessdate=}}
28. ^{{Cite journal | last1 = Relton | first1 = J. K. | last2 = Rothwell | first2 = N. J. | authorlink2 = Nancy Rothwell| doi = 10.1016/0361-9230(92)90033-T | title = Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat | journal = Brain Research Bulletin | volume = 29 | issue = 2 | pages = 243–246 | year = 1992 | pmid = 1388088| pmc = }}
29. ^{{Cite journal | last1 = Allan | first1 = S. M. | last2 = Rothwell | first2 = N. J. | authorlink2 = Nancy Rothwell| doi = 10.1038/35094583 | title = Cytokines and acute neurodegeneration | journal = Nature Reviews Neuroscience | volume = 2 | issue = 10 | pages = 734–744 | year = 2001 | pmid = 11584311| pmc = }}
30. ^{{Cite journal | last1 = Denes | first1 = A. | last2 = Wilkinson | first2 = F. | last3 = Bigger | first3 = B. | last4 = Chu | first4 = M. | last5 = Rothwell | first5 = N. J. | last6 = Allan | first6 = S. M. | doi = 10.1242/dmm.011601 | title = Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice | journal = Disease Models & Mechanisms | volume = 6 | issue = 4 | pages = 1043–1048 | year = 2013 | pmid = 23519030 | pmc = 3701223}}
31. ^{{cite book |author=Rothwell, Nancy |title=Who wants to be a scientist?: choosing science as a career |publisher=Cambridge University Press |location=Cambridge, UK |year=2002 |pages= |isbn=0-521-52092-4 |oclc= |doi= |accessdate=|authorlink=Nancy Rothwell}}
32. ^{{cite news|url=http://education.guardian.co.uk/manchesteruniversityunited/story/0,,1332549,00.html| title=Manchester voices--Nancy Rothwell |author=Cripps, Elizabeth|accessdate=2011-04-05|location=London|work=The Guardian}}
33. ^Christmas Lectures 1998: Nancy Rothwell - Times of our lives
34. ^{{cite web |url=http://www.bbc.co.uk/programmes/b007qlvb/features/power-list-100 |title=BBC Radio 4 - Woman's Hour - The Power List 2013 |work= |accessdate=}}
35. ^{{cite web |url=http://www.bbc.co.uk/programmes/b01qj7jd/profiles/nancy-rothwell |title=BBC Radio 4 - Woman's Hour, Woman's Hour Power List - Professor Dame Nancy Rothwell |work= |accessdate=}}
36. ^1 2 3 4 5 {{cite web|url=http://www.bbc.co.uk/programmes/b01s89mh |title=The Life Scientific; Nancy Rothwell |accessdate= 2013-05-07}}
37. ^{{cite news|url=http://news.bbc.co.uk/1/hi/uk/4079816.stm|title=Queen's Birthday Honours 2005 recipient lists|author=Anon|year=2005|publisher=BBC|website=news.bbc.co.uk}}
38. ^1 {{cite web|archiveurl=https://web.archive.org/web/20161011170939/https://royalsociety.org/people/nancy-rothwell-12203 |archivedate=11 October 2016 |url=https://royalsociety.org/people/nancy-rothwell-12203 |website=royalsociety.org |publisher=Royal Society |location=London |author=Anon |year=2004 |title=Dame Nancy Rothwell DBE DL FMedSci FRS |deadurl=yes |df= }} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{quote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{cite web|url=https://royalsociety.org/about-us/terms-conditions-policies/ |title=Royal Society Terms, conditions and policies |accessdate=2016-03-09 |deadurl=bot: unknown |archiveurl=https://web.archive.org/web/20150925220834/https://royalsociety.org/about-us/terms-conditions-policies/ |archivedate=25 September 2015 |df=dmy-all }}}}
39. ^Royal Society Pfizer Award
40. ^{{cite news|url=https://www.theguardian.com/education/2006/mar/28/highereducationprofile.research |title=Nancy Rothwell: Her own boss | Education | The Guardian: The head of research at the UK's biggest university tells Donald MacLeod she is unfazed by the task ahead, 2006-03-28 |work= |archivedate=10 July 2013 |archiveurl=https://www.webcitation.org/6I0SpQZho?url=http://www.guardian.co.uk/education/2006/mar/28/highereducationprofile.research |location=London |date=28 March 2006 |deadurl=yes |df=dmy }}
41. ^1 {{cite web|url=http://royalsociety.org/DServe/dserve.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=(RefNo==%27EC%2F2004%2F38%27) |title=Nancy Jane Rothwell: Certificate of election EC/2004/38 |publisher=The Royal Society |archivedate= 6 March 2014 |archiveurl=https://www.webcitation.org/6NsMSSifX?url=http://royalsociety.org/DServe/dserve.exe?dsqIni=Dserve.ini |location=London |deadurl=yes |df= }}
42. ^https://www.immunology.org/about-us/our-people/our-members/honorary-members

External links

  • {{Official website}}
{{commonscatinline}}{{S-start}}{{s-aca}}{{s-bef | before = Alan Gilbert}}{{s-ttl | title = Vice Chancellor and President of the University of Manchester | years = 2010–present}}{{s-inc}}
|-{{s-bef | before = -}}{{s-ttl | title = President of the Royal Society of Biology | years = 2009–2014}}{{s-aft | after = Jean Thomas}}
|-{{S-end}}{{Society of Biology Presidents}}{{FRS 2004}}{{Authority control}}{{DEFAULTSORT:Rothwell, Nancy}}

23 : 1955 births|Living people|Academics of the University of Manchester|Members of Academia Europaea|Vice-Chancellors of the University of Manchester|Alumni of King's College London|Alumni of Queen Elizabeth College|Alumni of the University of London|British academics|British physiologists|British medical researchers|Women biologists|British women scientists|Female Fellows of the Royal Society|Fellows of the Royal Society of Biology|Dames Commander of the Order of the British Empire|People from Tarleton|AstraZeneca people|Fellows of the Academy of Medical Sciences|Fellows of the Royal Society|Deputy Lieutenants of Greater Manchester|Fellows of Somerville College, Oxford|Female university and college presidents
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