| 词条 | Nepinalone |
| 释义 |
| Watchedfields = changed | verifiedrevid = 444509259 | IUPAC_name = 1-methyl-1-(2-piperidin-1-ylethyl)-3,4-dihydronaphthalen-2(1H)-one | image = Nepinalone.png | width = 120px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 22443-11-4 | ATC_prefix = R05 | ATC_suffix = DB26 | PubChem = 3047788 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2310106 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = L9806LPR7G | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07396 | C=18 | H=25 | N=1 | O=1 | molecular_weight = 271.397 g/mol | smiles = O=C2C(c1ccccc1CC2)(CCN3CCCCC3)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H25NO/c1-18(11-14-19-12-5-2-6-13-19)16-8-4-3-7-15(16)9-10-17(18)20/h3-4,7-8H,2,5-6,9-14H2,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = RVXGRCNWGOHSDE-UHFFFAOYSA-N }} Nepinalone is a cough suppressant. Its brand names include Placatus, Tussolvina, and Nepitus. The effect is evident after 20–30 minutes after administration and persists for at least 4 hours. It acts primarily at the level of the CNS, but also shows a slight activity in inhibiting the bronchospasm. In such use, it is less effective than codeine and more effective than dextromethorphan in inhibiting the tussive stimulus. [https://www.drugs.com/international/nepinalone.html] References{{Cough and cold preparations}}{{Sigma receptor modulators}}{{respiratory-system-drug-stub}} 4 : Antitussives|Piperidines|Ketones|Tetralins |
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