| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}The neuromedin B receptor (NMBR), now known as BB1 [1] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[2] Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[3] References1. ^{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2956 | title = Bombesin Receptors: BB1 | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
2. ^{{cite journal |vauthors=Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT | title = Expression and characterization of cloned human bombesin receptors | journal = Mol. Pharmacol. | volume = 47 | issue = 1 | pages = 10–20 | year = 1995 | pmid = 7838118 | doi = | issn = | url = http://molpharm.aspetjournals.org/cgi/content/abstract/47/1/10}}
3. ^{{cite web | title = Entrez Gene: NMBR neuromedin B receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4829| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Corjay MH, Dobrzanski DJ, Way JM, etal |title=Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. |journal=J. Biol. Chem. |volume=266 |issue= 28 |pages= 18771–9 |year= 1991 |pmid= 1655761 |doi= }}
- {{cite journal |vauthors=Wu JM, Hoang DO, Feldman RI |title=Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs. |journal=Mol. Pharmacol. |volume=47 |issue= 4 |pages= 871–81 |year= 1995 |pmid= 7723750 |doi= }}
- {{cite journal |vauthors=Benya RV, Kusui T, Pradhan TK, etal |title=Expression and characterization of cloned human bombesin receptors. |journal=Mol. Pharmacol. |volume=47 |issue= 1 |pages= 10–20 |year= 1995 |pmid= 7838118 |doi= }}
- {{cite journal |vauthors=Bitar KN, Zhu XX |title=Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction. |journal=Gastroenterology |volume=105 |issue= 6 |pages= 1672–80 |year= 1994 |pmid= 8253343 |doi= }}
- {{cite journal |vauthors=Giladi E, Nagalla SR, Spindel ER |title=Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. |journal=J. Mol. Neurosci. |volume=4 |issue= 1 |pages= 41–54 |year= 1993 |pmid= 8391296 |doi=10.1007/BF02736689 }}
- {{cite journal |vauthors=Fathi Z, Benya RV, Shapira H, etal |title=The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding. |journal=J. Biol. Chem. |volume=268 |issue= 20 |pages= 14622–6 |year= 1993 |pmid= 8392057 |doi= }}
- {{cite journal |vauthors=Kane MA, Toi-Scott M, Johnson GL, etal |title=Bombesin-like peptide receptors in human bronchial epithelial cells. |journal=Peptides |volume=17 |issue= 1 |pages= 111–8 |year= 1996 |pmid= 8822519 |doi=10.1016/0196-9781(95)02088-8 }}
- {{cite journal |vauthors=Sainz E, Akeson M, Mantey SA, etal |title=Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 15927–32 |year= 1998 |pmid= 9632639 |doi=10.1074/jbc.273.26.15927 }}
- {{cite journal |vauthors=Lee S, Kim Y |title=Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy. |journal=FEBS Lett. |volume=460 |issue= 2 |pages= 263–9 |year= 1999 |pmid= 10544247 |doi=10.1016/S0014-5793(99)01346-0 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Matusiak D, Glover S, Nathaniel R, etal |title=Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=288 |issue= 4 |pages= G718–28 |year= 2005 |pmid= 15528253 |doi= 10.1152/ajpgi.00156.2004 }}
{{refend}}External links- {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2956 | title = Bombesin Receptors: BB1 | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
- {{MeshName|Receptors,+Bombesin}}
{{NLM content}}{{G protein-coupled receptors}}{{transmembranereceptor-stub}} 1 : G protein-coupled receptors |