| 词条 | Neuropeptide Y receptor |
| 释义 |
| Name = neuropeptide Y receptor Y1 | caption = | image = | width = | HGNCid = 7956 | Symbol = NPY1R | AltSymbols = NPYR | EntrezGene = 4886 | OMIM = 162641 | RefSeq = NM_000909 | UniProt = P25929 | PDB = | ECnumber = | Chromosome = 4 | Arm = q | Band = 31.3 | LocusSupplementaryData = -q32 }}{{infobox protein | Name = neuropeptide Y receptor Y2 | caption = | image = | width = | HGNCid = 7957 | Symbol = NPY2R | AltSymbols = | EntrezGene = 4887 | OMIM = 162642 | RefSeq = NM_000910 | UniProt = P49146 | PDB = | ECnumber = | Chromosome = 4 | Arm = q | Band = 31 | LocusSupplementaryData = }}{{infobox protein | Name = pancreatic polypeptide receptor 1 | caption = | image = | width = | HGNCid = 9329 | Symbol = PPYR1 | AltSymbols = NPY4R, Y4, PP1 | EntrezGene = 5540 | OMIM = 601790 | RefSeq = NM_005972 | UniProt = P50391 | PDB = | ECnumber = | Chromosome = 10 | Arm = q | Band = 11.2 | LocusSupplementaryData = }}{{infobox protein | Name = neuropeptide Y receptor Y5 | caption = | image = | width = | HGNCid = 7958 | Symbol = NPY5R | AltSymbols = | EntrezGene = 4889 | OMIM = 602001 | RefSeq = NM_006174 | UniProt = Q15761 | PDB = | ECnumber = | Chromosome = 4 | Arm = q | Band = 31 | LocusSupplementaryData = -q32 }}Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.[1] These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.[2][3][4][5][6][7] Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP. Only the crystal structure of Y1 in complex with two antagonist is available.[8] TypesThere are five known mammalian neuropeptide Y receptors designated Y1 through Y5.[9] Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.[10][11][12]
Antagonists
References1. ^{{cite journal |vauthors=Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T | title = XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors | journal = Pharmacol. Rev. | volume = 50 | issue = 1 | pages = 143–50 |date=March 1998 | pmid = 9549761 | doi = | url = http://pharmrev.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9549761 | issn = }} 2. ^{{cite journal | author = Heilig M | title = The NPY system in stress, anxiety and depression | journal = Neuropeptides | volume = 38 | issue = 4 | pages = 213–24 |date=August 2004 | pmid = 15337373 | doi = 10.1016/j.npep.2004.05.002 }} 3. ^{{cite journal | author = Harro J | title = CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies | journal = Amino Acids | volume = 31 | issue = 3 | pages = 215–30 |date=October 2006 | pmid = 16738800 | doi = 10.1007/s00726-006-0334-x }} 4. ^{{cite journal |vauthors=Eaton K, Sallee FR, Sah R | title = Relevance of neuropeptide Y (NPY) in psychiatry | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1645–59 | year = 2007 | pmid = 17979774 | doi = 10.2174/156802607782341037 }} 5. ^{{cite journal |vauthors=Xapelli S, Agasse F, Ferreira R, Silva AP, Malva JO | title = Neuropeptide Y as an endogenous antiepileptic, neuroprotective and pro-neurogenic peptide | journal = Recent Patents on CNS Drug Discovery | volume = 1 | issue = 3 | pages = 315–24 |date=November 2006 | pmid = 18221213 | doi = 10.2174/157488906778773689 }} 6. ^{{cite journal |vauthors=Vona-Davis LC, McFadden DW | title = NPY family of hormones: clinical relevance and potential use in gastrointestinal disease | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1710–20 | year = 2007 | pmid = 17979780 | doi = 10.2174/156802607782340966 }} 7. ^{{cite journal |vauthors=Lindner D, Stichel J, Beck-Sickinger AG | title = Molecular recognition of the NPY hormone family by their receptors | journal = Nutrition (Burbank, Los Angeles County, Calif.) | volume = 24 | issue = 9 | pages = 907–17 |date=September 2008 | pmid = 18725086 | doi = 10.1016/j.nut.2008.06.025 }} 8. ^{{cite journal | vauthors = Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B | title = 1 receptor | journal = Nature | volume = 556 | issue = 7702 | pages = 520–524 | date = April 2018 | pmid = 29670288 | pmc = 5920736 | doi = 10.1038/s41586-018-0046-x }} 9. ^{{cite journal |vauthors=Larhammar D, Salaneck E | title = Molecular evolution of NPY receptor subtypes | journal = Neuropeptides | volume = 38 | issue = 4 | pages = 141–51 | year = 2004 | pmid = 15337367 | doi = 10.1016/j.npep.2004.06.002 }} 10. ^{{cite journal |vauthors=Kamiji MM, Inui A | title = Neuropeptide y receptor selective ligands in the treatment of obesity | journal = Endocrine Reviews | volume = 28 | issue = 6 | pages = 664–84 |date=October 2007 | pmid = 17785427 | doi = 10.1210/er.2007-0003 }} 11. ^{{cite journal | author = MacNeil DJ | title = NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1721–33 | year = 2007 | pmid = 17979781 | doi = 10.2174/156802607782341028 }} 12. ^{{cite journal |vauthors=Kamiji MM, Inui A | title = NPY Y2 and Y4 receptors selective ligands: promising anti-obesity drugs? | journal = Current Topics in Medicinal Chemistry | volume = 7 | issue = 17 | pages = 1734–42 | year = 2007 | pmid = 17979782 | doi = 10.2174/156802607782340957 }} External links
1 : G protein-coupled receptors |
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