| 词条 | Neuroprotectin |
| 释义 |
Neuroprotectin D1 (NPD1) (10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA. Like other members of the specialized proresolving mediators class of PUFA metabolites, NPD1 exerts potent[1] anti-inflammatory and anti-apoptotic/neuroprotective bioactivity.[2] Other neuroprotectins with similar activity include: PDX (10R,17S-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid); 20-hydroxy-PD1 (10R,17S,20-trihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid); and 10-epi-PD1 (10R,17S-Dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid).[3][4] The activity of neuroprotectin-like metabolite, 17-epi-PD1 (10R,17R-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid), has not yet been reported. Neuroprotectins A and B, which are bicyclohexapeptides, are to be distinguished structurally and mechanistically from the neuroprotectin D's.[5] See also
References1. ^{{cite journal |vauthors=Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN |title=Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation |journal=J. Biol. Chem. |volume=278 |issue=17 |pages=14677–87 |year=2003 |pmid=12590139 |doi=10.1074/jbc.M300218200}} {{biochem-stub}}2. ^{{cite journal |author=Bazan NG |authorlink1=Nicolas Bazan |title=Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection |journal=Current Opinion in Clinical Nutrition and Metabolic Care |volume=10 |issue=2 |pages=136–41 |year=2007 |pmid=17285000 |doi=10.1097/MCO.0b013e32802b7030}} 3. ^{{cite journal | vauthors = Balas L, Durand T | title = Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance | journal = Progress in Lipid Research | volume = 61 | issue = | pages = 1–18 | year = 2016 | pmid = 26545300 | doi = 10.1016/j.plipres.2015.10.002 | url = }} 4. ^{{cite journal | vauthors = Shinohara M, Mirakaj V, Serhan CN | title = Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome | journal = Frontiers in Immunology | volume = 3 | issue = | pages = 81 | year = 2012 | pmid = 22566962 | pmc = 3342038 | doi = 10.3389/fimmu.2012.00081 | url = }} 5. ^{{cite journal |vauthors=Kobayashi H, Shin-Ya K, Nagai K, etal |title=Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neuronal cells from excitotoxicity. I. Fermentation, isolation, physico-chemical properties and biological activity |journal=J. Antibiot. |volume=54 |issue=12 |pages=1013–8 |year=2001 |pmid=11858654 |doi=10.7164/antibiotics.54.1013}} 4 : Cell biology|Immunology|Metabolic pathways|Fatty acids |
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