请输入您要查询的百科知识：

　

词条 Neurotrophin-4
释义

  1. See also

  2. References

  3. Further reading

  4. External links

{{Infobox gene}}

Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.[1] It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.

See also

  • Tropomyosin receptor kinase B § Agonists

References

1. ^{{cite web | title = Entrez Gene: neurotrophin 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4909| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Childs AJ, Bayne RA, Murray AA, etal |title=Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development. |journal=Dev. Dyn. |volume=239 |issue= 4 |pages= 1211–9 |year= 2010 |pmid= 20175187 |doi= 10.1002/dvdy.22252 |pmc=3410523}}
  • {{cite journal |vauthors=Vithana EN, Nongpiur ME, Venkataraman D, etal |title=Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population. |journal=Mol. Vis. |volume=16 |issue= |pages= 1640–5 |year= 2010 |pmid= 20806036 |doi= |pmc=2927376}}
  • {{cite journal |vauthors=Truzzi F, Marconi A, Lotti R, etal |title=Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. |journal=J. Invest. Dermatol. |volume=128 |issue= 8 |pages= 2031–40 |year= 2008 |pmid= 18305571 |doi= 10.1038/jid.2008.21 }}
  • {{cite journal |vauthors=Harel S, Jin S, Fisch B, etal |title=Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults. |journal=Mol. Hum. Reprod. |volume=12 |issue= 6 |pages= 357–65 |year= 2006 |pmid= 16648150 |doi= 10.1093/molehr/gal033 }}
  • {{cite journal |vauthors=Ribasés M, Hervás A, Ramos-Quiroga JA|title=Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. |journal=Biol. Psychiatry |volume=63 |issue= 10 |pages= 935–45 |year= 2008 |pmid= 18179783 |doi= 10.1016/j.biopsych.2007.11.004 |display-authors=etal}}
  • {{cite journal |vauthors=Chen ZY, Ieraci A, Teng H, etal |title=Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. |journal=J. Neurosci. |volume=25 |issue= 26 |pages= 6156–66 |year= 2005 |pmid= 15987945 |doi= 10.1523/JNEUROSCI.1017-05.2005 |pmc=1201519}}
  • {{cite journal |vauthors=Pasutto F, Matsumoto T, Mardin CY, etal |title=Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. |journal=Am. J. Hum. Genet. |volume=85 |issue= 4 |pages= 447–56 |year= 2009 |pmid= 19765683 |doi= 10.1016/j.ajhg.2009.08.016 |pmc=2756554}}
  • {{cite journal |author=Ibáñez CF |title=Neurotrophin-4: the odd one out in the neurotrophin family. |journal=Neurochem. Res. |volume=21 |issue= 7 |pages= 787–93 |year= 1996 |pmid= 8873083 |doi= 10.1007/BF02532301 }}
  • {{cite journal |vauthors=Nalbandian A, Pang AL, Rennert OM, etal |title=A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression. |journal=Differentiation |volume=73 |issue= 8 |pages= 385–96 |year= 2005 |pmid= 16316409 |doi= 10.1111/j.1432-0436.2005.00040.x }}
  • {{cite journal |vauthors=Liu Y, Liu W, Crooks K, etal |title=No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. |journal=Am. J. Hum. Genet. |volume=86 |issue= 3 |pages= 498–9; author reply 500 |year= 2010 |pmid= 20215012 |doi= 10.1016/j.ajhg.2009.11.018 |pmc=2833375}}
  • {{cite journal |vauthors=Götz R, Schartl M |title=The conservation of neurotrophic factors during vertebrate evolution. |journal=Comp Biochem Physiol Pharmacol Toxicol Endocrinol |volume=108 |issue= 1 |pages= 1–10 |year= 1994 |pmid= 8061955 |doi= 10.1016/1367-8280(94)90082-5}}
  • {{cite journal |vauthors=Gratacòs M, EscaramÃs G, Bustamante M|title=Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. |journal=J Psychiatr Res |volume=44 |issue= 13 |pages= 834–40 |year= 2010 |pmid= 20219210 |doi= 10.1016/j.jpsychires.2010.01.009 |display-authors=etal}}
  • {{cite journal |vauthors=Chakrabarti B, Dudbridge F, Kent L, etal |title=Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. |journal=Autism Research |volume=2 |issue= 3 |pages= 157–77 |year= 2009 |pmid= 19598235 |doi= 10.1002/aur.80 }}
  • {{cite journal |vauthors=Mizuno N, Shiba H, Inui T, etal |title=Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells. |journal=J. Periodontol. |volume=79 |issue= 11 |pages= 2182–9 |year= 2008 |pmid= 18980528 |doi= 10.1902/jop.2008.070402 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
  • {{cite journal |vauthors=Rao KN, Kaur I, Parikh RS, etal |title=Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an Indian population. |journal=Invest. Ophthalmol. Vis. Sci. |volume=51 |issue= 10 |pages= 4937–41 |year= 2010 |pmid= 20463313 |doi= 10.1167/iovs.10-5553 }}
  • {{cite journal |vauthors=Gratacòs M, Costas J, de Cid R|title=Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=150B |issue= 6 |pages= 808–16 |year= 2009 |pmid= 19086053 |doi= 10.1002/ajmg.b.30902 |display-authors=etal}}
  • {{cite journal |author1=Mercader JM |author2=Saus E |author3=Agüera Z |title=Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. |journal=Hum. Mol. Genet. |volume=17 |issue= 9 |pages= 1234–44 |year= 2008 |pmid= 18203754 |doi= 10.1093/hmg/ddn013 |display-authors=etal}}
  • {{cite journal |author1=Walz JC |author2=Magalhães PV |author3=Giglio LM |title=Increased serum neurotrophin-4/5 levels in bipolar disorder. |journal=J Psychiatr Res |volume=43 |issue= 7 |pages= 721–3 |year= 2009 |pmid= 19081579 |doi= 10.1016/j.jpsychires.2008.10.005 |display-authors=etal}}
  • {{cite journal |vauthors=Prakash YS, Iyanoye A, Ay B, etal |title=Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=291 |issue= 3 |pages= L447–56 |year= 2006 |pmid= 16648236 |doi= 10.1152/ajplung.00501.2005 }}
{{refend}}

External links

  • {{MeshName|neurotrophin+4}}
  • {{MeshName|neurotrophin+5}}
{{PDB Gallery|geneid=4909}}{{Neurotrophins}}{{Growth factor receptor modulators}}{{gene-19-stub}}

6 : Neurotrophic factors|Peptide hormones|Growth factors|Developmental neuroscience|Proteins|TrkB agonists
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/11 18:31:01