“N-hydroxy-2-acetamidofluorene reductase”的意思、由来-开放百科全书

词条

N-hydroxy-2-acetamidofluorene reductase

释义

References

{{enzyme
| Name = N-hydroxy-2-acetamidofluorene reductase
| EC_number = 1.7.1.12
| CAS_number = 99890-08-1
| IUBMB_EC_number = 1/7/1/12
| GO_code = 0047137
| image =
| width =
| caption =
}}

In enzymology, a N-hydroxy-2-acetamidofluorene reductase ({{EC number|1.7.1.12}}) is an enzyme that catalyzes the chemical reaction

2-acetamidofluorene + NAD(P)+ + H₂O N-hydroxy-2-acetamidofluorene + NAD(P)H + H⁺

The 4 substrates of this enzyme are 2-acetamidofluorene, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are N-hydroxy-2-acetamidofluorene, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-acetamidofluorene:NAD(P)+ oxidoreductase. Other names in common use include N-hydroxy-2-acetylaminofluorene reductase, and NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase.

References

{{cite journal |vauthors=Gutmann HR, Erickson RR | date = 1969 | title = The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction | journal = J. Biol. Chem. | volume = 244 | pages = 1729–40 | pmid = 5780838 | issue = 7 }}
{{cite journal |vauthors=Kitamura S, Tatsumi K | date = 1985 | title = Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol | journal = Biochem. Biophys. Res. Commun. | volume = 133 | pages = 67–74 | pmid = 4074379 | doi = 10.1016/0006-291X(85)91842-X | issue = 1 }}

{{Nitrogenous donor oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{1.7-enzyme-stub}}

4 : EC 1.7.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of unknown structure

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