- References
| Name = nicotine dehydrogenase
| EC_number = 1.5.99.4
| CAS_number = 37256-31-8
| IUBMB_EC_number = 1/5/99/4
| GO_code = 0018535
| image =
| width =
| caption =
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In enzymology, a nicotine dehydrogenase ({{EC number|1.5.99.4}}) is an enzyme that catalyzes the chemical reaction
(S)-nicotine + acceptor + H2O(S)-6-hydroxynicotine + reduced acceptor
The 3 substrates of this enzyme are (S)-nicotine, acceptor, and H2O, whereas its two products are (S)-6-hydroxynicotine and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is nicotine:acceptor 6-oxidoreductase (hydroxylating). Other names in common use include nicotine oxidase, D-nicotine oxidase, nicotine:(acceptor) 6-oxidoreductase (hydroxylating), and L-nicotine oxidase. It has 2 cofactors: metal, and FMN.
References
- {{cite journal | vauthors = BEHRMAN EJ, STANIER RY | year = 1957 | title = The bacterial oxidation of nicotinic acid | journal = J. Biol. Chem. | volume = 228 | pages = 923–45 | pmid = 13475371 | issue = 2 }}
- {{cite journal | vauthors = Decker K, Bleeg H | year = 1965 | title = Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans | journal = Biochim. Biophys. Acta | volume = 105 | pages = 313–24 | pmid = 5849820 | issue = 2 | doi=10.1016/s0926-6593(65)80155-2}}
- {{cite journal | vauthors = Hochstein LI, Dalton BP | year = 1967 | title = The purification and properties of nicotine oxidase | journal = Biochim. Biophys. Acta | volume = 139 | pages = 56–68 | pmid = 4962139 | issue = 1 | doi = 10.1016/0005-2744(67)90113-1}}
- {{cite journal | vauthors = HOCHSTEIN LI, RITTENBERG SC | year = 1959 | title = The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine | journal = J. Biol. Chem. | volume = 234 | pages = 156–60 | pmid = 13610912 | issue = 1 }}
4 : EC 1.5.99|Metal enzymes|Flavin enzymes|Enzymes of unknown structure
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