| 词条 | Nicotinyl alcohol |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 387076743 | IUPAC_name = (Pyridin-3-yl)methanol | image = Nicotinyl alcohol.png | width = 120px | tradename = | Drugs.com = {{drugs.com|monograph|nitroglycerin}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 100-55-0 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 9TF312056Y | ATC_prefix = C10 | ATC_suffix = AD05 | ATC_supplemental = {{ATC|C04|AC02}} | ChEBI = 45213 | PubChem = 7510 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 7229 | synonyms = Roniacol; Roniacol tartrate; Nicotinyl tartrate;[1] Nicotinyl alcohol tartrate; Nicotinic alcohol; Pyridylcarbinol | C=6 | H=7 | N=1 | O=1 | molecular_weight = 109.126 g/mol | smiles = OCc1cccnc1 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C6H7NO/c8-5-6-2-1-3-7-4-6/h1-4,8H,5H2 }}Nicotinyl alcohol (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure.[2] It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 ºC.{{citation needed|date=June 2016}} Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper thorax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like arteriosclerosis obliterans,[3] Raynaud's disease,[4] thromboangiitis obliterans (Buerger's disease),[5] arterial embolism, chilblains or migraine associated with vascular spasm. Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in symptoms related to intermittent claudication,[6] ulcer healing and others.[7] References1. ^{{cite journal | pmid= 14066712 | journal = JAMA | date = 1963 | volume = 186 | pages = 1013 | author = Norwood WF | title = Vasodilator Effects of Nicotinyl Tartrate (Roniacol Tartrate) | doi = 10.1001/jama.1963.03710110065012 }} {{Lipid modifying agents}}{{Peripheral vasodilators}}2. ^{{cite web|url=http://www.online-medical-dictionary.org/Ronicol+Retard.asp?q=Ronicol+Retard|work=Medical Dictionary Online|title=Ronicol Retard|date=2012|accessdate=July 27, 2012|deadurl=yes|archiveurl=https://web.archive.org/web/20110614234933/http://www.online-medical-dictionary.org/Ronicol+Retard.asp?q=Ronicol+Retard|archivedate=June 14, 2011|df=}} 3. ^{{cite journal |vauthors=Richter IH, Fogel M, Fabricant H |title=An evaluation of roniacol tartrate in arteriosclerosis obliterans |journal=New York State Journal of Medicine |volume=51 |issue=10 |pages=1303–4 |year=1951 |pmid=14843421 }} 4. ^http://www.theodora.com/medical_dictionary/nicotine_nitrocellulose.html 5. ^http://es.slideshare.net/ravinarwal/buergers-disease-by-dr-ravinder-narwal Page 18 6. ^{{cite journal |vauthors=Gillhespy, RO |title=Nicotinyl Alcohol Tartrate in Intermittent Claudication |journal=British Medical Journal |volume=18 |issue=2 |pages=207–208 |year=1957 |pmid=1974214 }} 7. ^{{cite journal |vauthors=Fisher MM, Tebrock HW |title=Nicotinic alcohol (roniacol) in peripheral vascular diseases and allied conditions: its use and limitations |journal=New York State Journal of Medicine |volume=53 |issue=1 |pages=65–8 |year=1953 |pmid=13025721 }} 4 : Pyridines|Alcohols|Hypolipidemic agents|Vasodilators |
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