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词条 Nitric oxide synthase 2 (inducible)
释义

  1. Interactions

  2. References

{{Infobox_gene}}Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.[1]Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]

Interactions

Nitric oxide synthase 2A has been shown to interact with Caveolin 1[3] and Rac2.[4]

References

1. ^{{cite journal | vauthors = Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR | title = Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes | journal = Proc Natl Acad Sci USA | volume = 90 | issue = 8 | pages = 3491–5 | date = May 1993 | pmid = 7682706 | pmc = 46326 | doi = 10.1073/pnas.90.8.3491 }}
2. ^{{cite web | title = Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4843| accessdate = }}
3. ^{{cite journal | vauthors = Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF | title = Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 26 | pages = 14334–9 | date = December 2000 | pmid = 11114180 | pmc = 18919 | doi = 10.1073/pnas.250406797 }}
4. ^{{cite journal | vauthors = Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC | title = Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages | journal = Am. J. Physiol. Renal Physiol. | volume = 281 | issue = 2 | pages = F326–36 | date = August 2001 | pmid = 11457725 }}
{{PDB Gallery|geneid=4843}}{{Neurotransmitter metabolism enzymes}}{{Dioxygenases}}{{Enzymes}}{{Nitric oxide signaling}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-17-stub}}

1 : EC 1.14.13

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