“Nitroquinoline-N-oxide reductase”的意思、由来-开放百科全书

词条

Nitroquinoline-N-oxide reductase

释义

References

{{enzyme
| Name = nitroquinoline-N-oxide reductase
| EC_number = 1.7.1.9
| CAS_number = 37256-35-2
| IUBMB_EC_number = 1/7/1/9
| GO_code = 0050465
| image =
| width =
| caption =
}}

In enzymology, a nitroquinoline-N-oxide reductase ({{EC number|1.7.1.9}}) is an enzyme that catalyzes the chemical reaction

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H₂O 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are 4-hydroxyaminoquinoline N-oxide, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are 4-nitroquinoline N-oxide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO reductase, and NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase.

References

{{cite journal | author = Toriyama N | date = 1965 | title = [Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide] | journal = Nichidai Igaku Zasshi | volume = 24 | pages = 423–432 }}
{{cite journal | vauthors = Stanley JS, York JL, Benson AM | date = 1992 | title = Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice | journal = Cancer Res. | volume = 52 | pages = 58–63 | pmid = 1370076 | issue = 1 }}

{{Nitrogenous donor oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{1.7-enzyme-stub}}

4 : EC 1.7.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of unknown structure

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