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词条 NME1
释义

  1. Function

  2. Interactions

  3. See also

  4. References

  5. Further reading

{{Infobox_gene}}

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene.[1] It is thought to be a metastasis suppressor.

Function

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.[2]

Interactions

NME1 has been shown to interact with:

{{div col|colwidth=20em}}
  • Aurora A kinase,[3]
  • CD29[4]
  • NME3,[5][6]
  • Protein SET,[7]
  • RAR-related orphan receptor alpha,[8]
  • RAR-related orphan receptor beta,[8] and
  • TERF1.[9]
{{Div col end}}

See also

  • Nucleoside-diphosphate kinase

References

1. ^{{cite journal | vauthors = Dooley S, Seib T, Engel M, Theisinger B, Janz H, Piontek K, Zang KD, Welter C | title = Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1 | journal = Hum. Genet. | volume = 93 | issue = 1 | pages = 63–6 | date = February 1994 | pmid = 8270257 | pmc = | doi = 10.1007/bf00218915 }}
2. ^{{cite web | title = Entrez Gene: NME1 non-metastatic cells 1, protein (NM23A) expressed in| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4830| accessdate = }}
3. ^{{cite journal | vauthors = Du J, Hannon GJ | title = The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1 | journal = Nucleic Acids Res. | volume = 30 | issue = 24 | pages = 5465–75 | date = December 2002 | pmid = 12490715 | pmc = 140054 | doi = 10.1093/nar/gkf678}}
4. ^{{cite journal | vauthors = Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C | title = Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement | journal = J. Biol. Chem. | volume = 277 | issue = 23 | pages = 20895–902 | date = June 2002 | pmid = 11919189 | doi = 10.1074/jbc.M200200200 }}
5. ^{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
6. ^{{cite journal | vauthors = Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G | title = Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis | journal = Cell Death Differ. | volume = 7 | issue = 9 | pages = 843–50 | date = September 2000 | pmid = 11042679 | doi = 10.1038/sj.cdd.4400720 }}
7. ^{{cite journal | vauthors = Chakravarti D, Hong R | title = SET-ting the stage for life and death | journal = Cell | volume = 112 | issue = 5 | pages = 589–91 | date = March 2003 | pmid = 12628178 | doi = 10.1016/s0092-8674(03)00151-x}}
8. ^1 {{cite journal | vauthors = Paravicini G, Steinmayr M, André E, Becker-André M | title = The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily | journal = Biochem. Biophys. Res. Commun. | volume = 227 | issue = 1 | pages = 82–7 | date = October 1996 | pmid = 8858107 | doi = 10.1006/bbrc.1996.1471 }}
9. ^{{cite journal | vauthors = Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H | title = Association of nucleoside diphosphate kinase nm23-H2 with human telomeres | journal = Biochem. Biophys. Res. Commun. | volume = 243 | issue = 2 | pages = 342–8 | date = February 1998 | pmid = 9480811 | doi = 10.1006/bbrc.1997.8097 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Freije JM, MacDonald NJ, Steeg PS | title = Nm23 and tumour metastasis: basic and translational advances | journal = Biochem. Soc. Symp. | volume = 63 | issue = | pages = 261–71 | year = 1998 | pmid = 9513729 | doi = }}
  • {{cite journal | vauthors = Roymans D, Willems R, Van Blockstaele DR, Slegers H | title = Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis | journal = Clin. Exp. Metastasis | volume = 19 | issue = 6 | pages = 465–76 | year = 2002 | pmid = 12405283 | doi = 10.1023/A:1020396722860 }}
  • {{cite journal | vauthors = Tee YT, Chen GD, Lin LY, Ko JL, Wang PH | title = Nm23-H1: a metastasis-associated gene | journal = Taiwan J Obstet Gynecol | volume = 45 | issue = 2 | pages = 107–13 | year = 2006 | pmid = 17197349 | doi = 10.1016/S1028-4559(09)60206-0 }}
  • {{cite journal | vauthors = Gilles AM, Presecan E, Vonica A, Lascu I | title = Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme | journal = J. Biol. Chem. | volume = 266 | issue = 14 | pages = 8784–9 | year = 1991 | pmid = 1851158 | doi = }}
  • {{cite journal | vauthors = Leone A, McBride OW, Weston A, Wang MG, Anglard P, Cropp CS, Goepel JR, Lidereau R, Callahan R, Linehan WM | title = Somatic allelic deletion of nm23 in human cancer | journal = Cancer Res. | volume = 51 | issue = 9 | pages = 2490–3 | year = 1991 | pmid = 2015608 | doi = }}
  • {{cite journal | vauthors = Hailat N, Keim DR, Melhem RF, Zhu XX, Eckerskorn C, Brodeur GM, Reynolds CP, Seeger RC, Lottspeich F, Strahler JR | title = High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification | journal = J. Clin. Invest. | volume = 88 | issue = 1 | pages = 341–5 | year = 1991 | pmid = 2056128 | pmc = 296039 | doi = 10.1172/JCI115299 }}
  • {{cite journal | vauthors = Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker E, Margulies IM, King CR, Liotta LA, Steeg PS | title = Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development | journal = Nature | volume = 342 | issue = 6246 | pages = 177–80 | year = 1989 | pmid = 2509941 | doi = 10.1038/342177a0 }}
  • {{cite journal | vauthors = Wang L, Patel U, Ghosh L, Chen HC, Banerjee S | title = Mutation in the nm23 gene is associated with metastasis in colorectal cancer | journal = Cancer Res. | volume = 53 | issue = 4 | pages = 717–20 | year = 1993 | pmid = 7916650 | doi = }}
  • {{cite journal | vauthors = Chang CL, Zhu XX, Thoraval DH, Ungar D, Rawwas J, Hora N, Strahler JR, Hanash SM, Radany E | title = Nm23-H1 mutation in neuroblastoma | journal = Nature | volume = 370 | issue = 6488 | pages = 335–6 | year = 1994 | pmid = 8047138 | doi = 10.1038/370335a0 | url = https://deepblue.lib.umich.edu/bitstream/2027.42/62612/1/370335a0.pdf }}
  • {{cite journal | vauthors = MacDonald NJ, De la Rosa A, Benedict MA, Freije JM, Krutsch H, Steeg PS | title = A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential | journal = J. Biol. Chem. | volume = 268 | issue = 34 | pages = 25780–9 | year = 1993 | pmid = 8245015 | doi = }}
  • {{cite journal | vauthors = Postel EH, Berberich SJ, Flint SJ, Ferrone CA | title = Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis | journal = Science | volume = 261 | issue = 5120 | pages = 478–80 | year = 1993 | pmid = 8392752 | doi = 10.1126/science.8392752 }}
  • {{cite journal | vauthors = Sudbrak R, Golla A, Hogan K, Powers P, Gregg R, Du Chesne I, Lehmann-Horn F, Deufel T | title = Exclusion of malignant hyperthermia susceptibility (MHS) from a putative MHS2 locus on chromosome 17q and of the alpha 1, beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect | journal = Hum. Mol. Genet. | volume = 2 | issue = 7 | pages = 857–62 | year = 1993 | pmid = 8395939 | doi = 10.1093/hmg/2.7.857 }}
  • {{cite journal | vauthors = MacDonald NJ, Freije JM, Stracke ML, Manrow RE, Steeg PS | title = Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells | journal = J. Biol. Chem. | volume = 271 | issue = 41 | pages = 25107–16 | year = 1996 | pmid = 8810265 | doi = 10.1074/jbc.271.41.25107 }}
  • {{cite journal | vauthors = Paravicini G, Steinmayr M, André E, Becker-André M | title = The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily | journal = Biochem. Biophys. Res. Commun. | volume = 227 | issue = 1 | pages = 82–7 | year = 1996 | pmid = 8858107 | doi = 10.1006/bbrc.1996.1471 }}
  • {{cite journal | vauthors = Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H | title = Association of nucleoside diphosphate kinase nm23-H2 with human telomeres | journal = Biochem. Biophys. Res. Commun. | volume = 243 | issue = 2 | pages = 342–8 | year = 1998 | pmid = 9480811 | doi = 10.1006/bbrc.1997.8097 }}
  • {{cite journal | vauthors = Schaertl S, Konrad M, Geeves MA | title = Substrate specificity of human nucleoside-diphosphate kinase revealed by transient kinetic analysis | journal = J. Biol. Chem. | volume = 273 | issue = 10 | pages = 5662–9 | year = 1998 | pmid = 9488696 | doi = 10.1074/jbc.273.10.5662 }}
  • {{cite journal | vauthors = Willems R, Van Bockstaele DR, Lardon F, Lenjou M, Nijs G, Snoeck HW, Berneman ZN, Slegers H | title = Decrease in nucleoside diphosphate kinase (NDPK/nm23) expression during hematopoietic maturation | journal = J. Biol. Chem. | volume = 273 | issue = 22 | pages = 13663–8 | year = 1998 | pmid = 9593706 | doi = 10.1074/jbc.273.22.13663 }}
  • {{cite journal | vauthors = Manda R, Kohno T, Matsuno Y, Takenoshita S, Kuwano H, Yokota J | title = Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display | journal = Genomics | volume = 61 | issue = 1 | pages = 5–14 | year = 1999 | pmid = 10512675 | doi = 10.1006/geno.1999.5939 }}
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