| 词条 | Nuciferine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 400333505 | ImageFile=Nuciferine.png | ImageSize=220px | IUPACName=(6aR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | OtherNames=(R)-1,2-Dimethoxyaporphine |Section1={{Chembox Identifiers | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 464529 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 9740 | InChI = 1/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1 | InChIKey = ORJVQPIHKOARKV-OAHLLOKOBA | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = ORJVQPIHKOARKV-OAHLLOKOSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=475-83-2 | PubChem = 10146 | SMILES = CN(CC1)[C@]2([H])CC3=CC=CC=C3C4=C2C1=CC(OC)=C4OC | MeSHName= |Section2={{Chembox Properties | Formula=C19H21NO2 | MolarMass=295.376 g/mol | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Nuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.[1] It induces sedation, hypothermia, ptosis, and (in higher doses) catalepsy; it inhibits spontaneous motor activity, conditioned avoidance response, amphetamine toxicity and stereotypy. Nuciferine may also potentiate morphine analgesia. The median lethal dose in mice is 289 mg/kg. It is structurally related to apomorphine.[2][3] See also{{cmn|colwidth=30em|
}} References1. ^Farrell MS et al. (2016): "In Vitro and In Vivo Characterization of the Alkaloid Nuciferine", PLoS One. {{PMID|26963248}} {{Dopaminergics}}{{sedative-stub}}2. ^{{cite journal |doi=10.1007/BF00428026 |vauthors=Bhattacharya SK, Bose R, Ghosh P, Tripathi VJ, Ray AB, Dasgupta B |title=Psychopharmacological studies on (—)-nuciferine and its Hofmann degradation product atherosperminine |journal=Psychopharmacology |volume=59 |issue=1 |pages=29–33 |date=Sep 1978 |pmid=100809 }} 3. ^Spess, David L. Errors in Alkaloids of Nelumbo and Nymphaea species, 2011, academia.edu 2 : Phenol ethers|Alkaloids |
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