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词条 Nuclear receptor coactivator 1
释义

  1. Interactions

  2. References

  3. External links

  4. Further reading

{{Infobox_gene}}

The nuclear receptor coactivator 1 ({{gene|NCOA1}}) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity ({{EC number|2.3.1.48}}). NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.[1][2]

NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).

Interactions

Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:

{{div col|colwidth=20em}}
  • Androgen receptor,[3][4][5]
  • C-Fos,[6][7]
  • C-jun,[6][7][8]
  • CIITA,[9]
  • CREB-binding protein,[10][11]
  • Cyclin D1,[12]
  • DDX17,[13]
  • DDX5[13] and
  • Estrogen receptor alpha,[10][13][14][15][16]
  • Glucocorticoid receptor,[17][18]
  • NFKB1,[6][19]
  • PCAF,[20]
  • PPARGC1A,[21]
  • Peroxisome proliferator-activated receptor alpha,[22][23]
  • SNW1,[24]
  • STAT3,[25]
  • STAT6,[26][27]
  • TRIP4,[28] and
  • Thyroid hormone receptor beta.[29][30]
{{Div col end}}

References

1. ^{{cite journal | vauthors = Oñate SA, Tsai SY, Tsai MJ, O'Malley BW | title = Sequence and characterization of a coactivator for the steroid hormone receptor superfamily | journal = Science | volume = 270 | issue = 5240 | pages = 1354–1357 | year = 1995 | pmid = 7481822 | doi = 10.1126/science.270.5240.1354 }}
2. ^{{cite journal | vauthors = Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW | title = The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors | journal = Journal of Biological Chemistry| volume = 273 | issue = 20 | pages = 12101–12108 | year = 1998 | pmid = 9575154 | doi = 10.1074/jbc.273.20.12101 }}
3. ^{{cite journal | vauthors = Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP | title = Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells | journal = Molecular Endocrinology | volume = 18 | issue = 10 | pages = 2388–2401 | date = Oct 2004 | pmid = 15256534 | doi = 10.1210/me.2003-0436 }}
4. ^{{cite journal | vauthors = Ueda T, Mawji NR, Bruchovsky N, Sadar MD | title = Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells | journal = Journal of Biological Chemistry | volume = 277 | issue = 41 | pages = 38087–38094 | date = Oct 2002 | pmid = 12163482 | doi = 10.1074/jbc.M203313200 }}
5. ^{{cite journal | vauthors = Bevan CL, Hoare S, Claessens F, Heery DM, Parker MG | title = The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1 | journal = Molecular and Cellular Biology | volume = 19 | issue = 12 | pages = 8383–8392 | date = Dec 1999 | pmid = 10567563 | pmc = 84931 | doi = 10.1128/mcb.19.12.8383}}
6. ^1 2 {{cite journal | vauthors = Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW | title = Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2 | journal = Molecular Endocrinology | volume = 14 | issue = 6 | pages = 915–925 | date = Jun 2000 | pmid = 10847592 | doi = 10.1210/mend.14.6.0471 }}
7. ^1 {{cite journal | vauthors = Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW | title = Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits | journal = Journal of Biological Chemistry | volume = 273 | issue = 27 | pages = 16651–16654 | date = Jul 1998 | pmid = 9642216 | doi = 10.1074/jbc.273.27.16651 }}
8. ^{{cite journal | vauthors = Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW | title = A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo | journal = Journal of Biological Chemistry | volume = 274 | issue = 48 | pages = 34283–34293 | date = Nov 1999 | pmid = 10567404 | doi = 10.1074/jbc.274.48.34283 }}
9. ^{{cite journal | vauthors = Tzortzakaki E, Spilianakis C, Zika E, Kretsovali A, Papamatheakis J | title = Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways | journal = Molecular Endocrinology | volume = 17 | issue = 12 | pages = 2509–2518 | date = Dec 2003 | pmid = 12933903 | doi = 10.1210/me.2002-0439 }}
10. ^1 {{cite journal | vauthors = Sheppard HM, Harries JC, Hussain S, Bevan C, Heery DM | title = Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1 | journal = Molecular and Cellular Biology | volume = 21 | issue = 1 | pages = 39–50 | date = Jan 2001 | pmid = 11113179 | pmc = 86566 | doi = 10.1128/MCB.21.1.39-50.2001 }}
11. ^{{cite journal | vauthors = Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW | title = Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase | journal = Molecular and Cellular Biology | volume = 22 | issue = 10 | pages = 3549–3461 | date = May 2002 | pmid = 11971985 | pmc = 133790 | doi = 10.1128/MCB.22.10.3549-3561.2002 }}
12. ^{{cite journal | vauthors = Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R | title = Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1 | journal = Genes & Development | volume = 12 | issue = 22 | pages = 3488–3498 | date = Nov 1998 | pmid = 9832502 | pmc = 317237 | doi = 10.1101/gad.12.22.3488 }}
13. ^1 2 {{cite journal | vauthors = Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S | title = A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA | journal = EMBO Journal | volume = 20 | issue = 6 | pages = 1341–1352 | date = Mar 2001 | pmid = 11250900 | pmc = 145523 | doi = 10.1093/emboj/20.6.1341 }}
14. ^{{cite journal | vauthors = DiRenzo J, Shang Y, Phelan M, Sif S, Myers M, Kingston R, Brown M | title = BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation | journal = Molecular and Cellular Biology | volume = 20 | issue = 20 | pages = 7541–7549 | date = Oct 2000 | pmid = 11003650 | pmc = 86306 | doi = 10.1128/MCB.20.20.7541-7549.2000 }}
15. ^{{cite journal | vauthors = Kalkhoven E, Valentine JE, Heery DM, Parker MG | title = Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor | journal = EMBO Journal | volume = 17 | issue = 1 | pages = 232–243 | date = Jan 1998 | pmid = 9427757 | pmc = 1170374 | doi = 10.1093/emboj/17.1.232 }}
16. ^{{cite journal | vauthors = Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro | journal = Proceedings of the National Academy of Sciences, USA | volume = 99 | issue = 5 | pages = 2642–2647 | date = Mar 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 }}
17. ^{{cite journal | vauthors = Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA | title = Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140 | journal = Molecular Endocrinology | volume = 15 | issue = 4 | pages = 501–511 | date = Apr 2001 | pmid = 11266503 | doi = 10.1210/mend.15.4.0624 }}
18. ^{{cite journal | vauthors = Kucera T, Waltner-Law M, Scott DK, Prasad R, Granner DK | title = A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1 | journal = Journal of Biological Chemistry | volume = 277 | issue = 29 | pages = 26098–260102 | date = Jul 2002 | pmid = 12118039 | doi = 10.1074/jbc.M204013200 }}
19. ^{{cite journal | vauthors = Na SY, Lee SK, Han SJ, Choi HS, Im SY, Lee JW | title = Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations | journal = Journal of Biological Chemistry | volume = 273 | issue = 18 | pages = 10831–10834 | date = May 1998 | pmid = 9556555 | doi = 10.1074/jbc.273.18.10831 }}
20. ^{{cite journal | vauthors = Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW | title = Steroid receptor coactivator-1 is a histone acetyltransferase | journal = Nature | volume = 389 | issue = 6647 | pages = 194–198 | date = Sep 1997 | pmid = 9296499 | doi = 10.1038/38304 }}
21. ^{{cite journal | vauthors = Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM | title = Activation of PPARgamma coactivator-1 through transcription factor docking | journal = Science | volume = 286 | issue = 5443 | pages = 1368–1371 | date = Nov 1999 | pmid = 10558993 | doi = 10.1126/science.286.5443.1368 }}
22. ^{{cite journal | vauthors = Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M | title = p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha | journal = Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 33435–33443 | date = Dec 1997 | pmid = 9407140 | doi = 10.1074/jbc.272.52.33435 }}
23. ^{{cite journal | vauthors = Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson JA | title = A regulatory role for RIP140 in nuclear receptor activation | journal = Molecular Endocrinology | volume = 12 | issue = 6 | pages = 864–881 | date = Jun 1998 | pmid = 9626662 | doi = 10.1210/mend.12.6.0123 }}
24. ^{{cite journal | vauthors = Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN | title = Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription | journal = Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 40614–40620 | date = Nov 2001 | pmid = 11514567 | doi = 10.1074/jbc.M106263200 }}
25. ^{{cite journal | vauthors = Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O | title = Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a | journal = Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8004–811 | date = Mar 2002 | pmid = 11773079 | doi = 10.1074/jbc.M111486200 }}
26. ^{{cite journal | vauthors = Litterst CM, Pfitzner E | title = Transcriptional activation by STAT6 requires the direct interaction with NCoA-1 | journal = Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 45713–45721 | date = Dec 2001 | pmid = 11574547 | doi = 10.1074/jbc.M108132200 }}
27. ^{{cite journal | vauthors = Litterst CM, Pfitzner E | title = An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1 | journal = Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 36052–36060 | date = Sep 2002 | pmid = 12138096 | doi = 10.1074/jbc.M203556200 }}
28. ^{{cite journal | vauthors = Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW | title = Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation | journal = Molecular and Cellular Biology | volume = 19 | issue = 9 | pages = 6323–6332 | date = Sep 1999 | pmid = 10454579 | pmc = 84603 | doi = 10.1128/mcb.19.9.6323}}
29. ^{{cite journal | vauthors = Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM | title = Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors | journal = Endocrinology | volume = 139 | issue = 10 | pages = 4197–4204 | date = Oct 1998 | pmid = 9751500 | doi = 10.1210/endo.139.10.6218 }}
30. ^{{cite journal | vauthors = Jeyakumar M, Tanen MR, Bagchi MK | title = Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor | journal = Molecular Endocrinology | volume = 11 | issue = 6 | pages = 755–767 | date = Jun 1997 | pmid = 9171239 | doi = 10.1210/mend.11.6.0003 }}

External links

  • {{MeshName|nuclear+receptor+coactivator+1|3=nuclear receptor coactivator 1}}
  • {{NURSA|C89}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Qi C, Zhu Y, Reddy JK | title = Peroxisome proliferator-activated receptors, coactivators, and downstream targets | journal = Cell Biochemistry and Biophysics | volume = Spring | issue = | pages = 187–204 | year = 2001 | pmid = 11330046 | doi = | series = 32 }}
{{refend}}{{PDB Gallery|geneid=8648}}{{Transcription coregulators}}

2 : Transcription coregulators|PAS-domain-containing proteins
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