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词条 Nuclear receptor coactivator 3
释义

  1. Function

  2. Clinical significance

  3. Interactions

  4. References

  5. External links

  6. Further reading

{{Infobox_gene}}

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.[1][2] NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.[3][4]

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.[5][6]

Interactions

Nuclear receptor coactivator 3 has been shown to interact with:

{{div col|colwidth=20em}}
  • Androgen receptor,[7][8][9]
  • CHUK[10] and
  • CREB-binding protein,[10][10]
  • DDX17,[11]
  • DDX5,[11]
  • Estrogen receptor alpha,[11][12][13]
  • Estrogen receptor beta,[12][14]
  • Glucocorticoid receptor,[15][16]
  • IKBKG,[10]
  • IKK2,[17]
  • Peroxisome proliferator-activated receptor gamma,[18] and
  • Retinoid X receptor alpha.[19][20]
{{Div col end}}

References

1. ^{{cite journal | vauthors = Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS | title = AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer | journal = Science | volume = 277 | issue = 5328 | pages = 965–8 | date = August 1997 | pmid = 9252329 | doi = 10.1126/science.277.5328.965 | url = }}
2. ^{{cite journal | vauthors = Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW | title = TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1 | journal = J. Biol. Chem. | volume = 272 | issue = 44 | pages = 27629–34 | date = October 1997 | pmid = 9346901 | doi = 10.1074/jbc.272.44.27629 | url = }}
3. ^{{cite journal | vauthors = Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS | title = AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer | journal = Science | volume = 277 | issue = 5328 | pages = 965–8 | year = 1997 | pmid = 9252329 | doi = 10.1126/science.277.5328.965 }}
4. ^{{cite journal | vauthors = Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW | title = TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1 | journal = J Biol Chem | volume = 272 | issue = 44 | pages = 27629–34 | year = 1997 | pmid = 9346901 | doi = 10.1074/jbc.272.44.27629 }}
5. ^{{cite web | url = http://cordis.europa.eu/fetch?CALLER=EN_NEWS&ACTION=D&SESSION=&RCN=30093 | title = Study sheds new light on tamoxifen resistance | authorlink = | date = 2008-11-13 | format = | work = Cordis News | publisher = Cordis | pages = | archiveurl = | archivedate = | quote = | accessdate = 2008-11-14}}
6. ^{{cite journal | vauthors = Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS | title = Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen | journal = Nature | volume = 456 | issue = 7222 | pages = 663–6 | date = December 2008 | pmid = 19005469 | pmc = 2920208 | doi = 10.1038/nature07483 | url = }}
7. ^{{cite journal | vauthors = Tan JA, Hall SH, Petrusz P, French FS | title = Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator | journal = Endocrinology | volume = 141 | issue = 9 | pages = 3440–50 | date = September 2000 | pmid = 10965917 | doi = 10.1210/endo.141.9.7680 }}
8. ^{{cite journal | vauthors = Gnanapragasam VJ, Leung HY, Pulimood AS, Neal DE, Robson CN | title = Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer | journal = Br. J. Cancer | volume = 85 | issue = 12 | pages = 1928–36 | date = December 2001 | pmid = 11747336 | pmc = 2364015 | doi = 10.1054/bjoc.2001.2179 }}
9. ^{{cite journal | vauthors = Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD | title = Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells | journal = J. Biol. Chem. | volume = 279 | issue = 17 | pages = 17319–28 | date = April 2004 | pmid = 14966121 | doi = 10.1074/jbc.M400970200 }}
10. ^{{cite journal | vauthors = Naltner A, Wert S, Whitsett JA, Yan C | title = Temporal/spatial expression of nuclear receptor coactivators in the mouse lung | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 279 | issue = 6 | pages = L1066-74 | date = December 2000 | pmid = 11076796 | doi = 10.1152/ajplung.2000.279.6.l1066}}
11. ^1 2 {{cite journal | vauthors = Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S | title = A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1341–52 | date = March 2001 | pmid = 11250900 | pmc = 145523 | doi = 10.1093/emboj/20.6.1341 }}
12. ^1 {{cite journal | vauthors = Wong CW, Komm B, Cheskis BJ | title = Structure-function evaluation of ER alpha and beta interplay with SRC family coactivators. ER selective ligands | journal = Biochemistry | volume = 40 | issue = 23 | pages = 6756–65 | date = June 2001 | pmid = 11389589 | doi = 10.1021/bi010379h }}
13. ^{{cite journal | vauthors = Tikkanen MK, Carter DJ, Harris AM, Le HM, Azorsa DO, Meltzer PS, Murdoch FE | title = Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 23 | pages = 12536–40 | date = November 2000 | pmid = 11050174 | pmc = 18799 | doi = 10.1073/pnas.220427297 }}
14. ^{{cite journal | vauthors = Leo C, Li H, Chen JD | title = Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3 | journal = J. Biol. Chem. | volume = 275 | issue = 8 | pages = 5976–82 | date = February 2000 | pmid = 10681591 | doi = 10.1074/jbc.275.8.5976 }}
15. ^{{cite journal | vauthors = Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK | title = BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation | journal = Mol. Cell. Biol. | volume = 23 | issue = 17 | pages = 6210–20 | date = September 2003 | pmid = 12917342 | pmc = 180928 | doi = 10.1128/MCB.23.17.6210-6220.2003 }}
16. ^{{cite journal | vauthors = Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA | title = Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140 | journal = Mol. Endocrinol. | volume = 15 | issue = 4 | pages = 501–11 | date = April 2001 | pmid = 11266503 | doi = 10.1210/mend.15.4.0624 }}
17. ^1 2 3 {{cite journal | vauthors = Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW | title = Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase | journal = Mol. Cell. Biol. | volume = 22 | issue = 10 | pages = 3549–61 | date = May 2002 | pmid = 11971985 | pmc = 133790 | doi = 10.1128/MCB.22.10.3549-3561.2002 }}
18. ^{{cite journal | vauthors = Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S | title = Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators | journal = J. Biol. Chem. | volume = 275 | issue = 43 | pages = 33201–4 | date = October 2000 | pmid = 10944516 | doi = 10.1074/jbc.C000517200 | pmc = 3798517 }}
19. ^{{cite journal | vauthors = Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM | title = Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300 | journal = Cell | volume = 90 | issue = 3 | pages = 569–80 | date = August 1997 | pmid = 9267036 | doi = 10.1016/S0092-8674(00)80516-4 }}
20. ^{{cite journal | vauthors = Lee WY, Noy N | title = Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain | journal = Biochemistry | volume = 41 | issue = 8 | pages = 2500–8 | date = February 2002 | pmid = 11851396 | doi = 10.1021/bi011764 }}

External links

  • {{MeshName|nuclear+receptor+coactivator+3|3=nuclear receptor coactivator 3}}
  • {{NURSA|C91}}

Further reading

{{refbegin|35em}}
  • {{cite journal | vauthors = Liao L, Kuang SQ, Yuan Y, Gonzalez SM, O'Malley BW, Xu J | title = Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1 | journal = J. Steroid Biochem. Mol. Biol. | volume = 83 | issue = 1–5 | pages = 3–14 | year = 2003 | pmid = 12650696 | doi = 10.1016/S0960-0760(02)00254-6 }}
  • {{cite journal | vauthors = Liu F, Ventura F, Doody J, Massagué J | title = Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs | journal = Mol. Cell. Biol. | volume = 15 | issue = 7 | pages = 3479–86 | year = 1995 | pmid = 7791754 | pmc = 230584 | doi = 10.1128/mcb.15.7.3479}}
  • {{cite journal | vauthors = Guan XY, Xu J, Anzick SL, Zhang H, Trent JM, Meltzer PS | title = Hybrid selection of transcribed sequences from microdissected DNA: isolation of genes within amplified region at 20q11-q13.2 in breast cancer | journal = Cancer Res. | volume = 56 | issue = 15 | pages = 3446–50 | year = 1996 | pmid = 8758910 | doi = }}
  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
  • {{cite journal | vauthors = Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA | title = cDNAs with long CAG trinucleotide repeats from human brain | journal = Hum. Genet. | volume = 100 | issue = 1 | pages = 114–22 | year = 1997 | pmid = 9225980 | doi = 10.1007/s004390050476 }}
  • {{cite journal | vauthors = Li H, Gomes PJ, Chen JD | title = RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8479–84 | year = 1997 | pmid = 9238002 | pmc = 22964 | doi = 10.1073/pnas.94.16.8479 }}
  • {{cite journal | vauthors = Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS | title = AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer | journal = Science | volume = 277 | issue = 5328 | pages = 965–8 | year = 1997 | pmid = 9252329 | doi = 10.1126/science.277.5328.965 }}
  • {{cite journal | vauthors = Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM | title = Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300 | journal = Cell | volume = 90 | issue = 3 | pages = 569–80 | year = 1997 | pmid = 9267036 | doi = 10.1016/S0092-8674(00)80516-4 }}
  • {{cite journal | vauthors = Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW | title = TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1 | journal = J. Biol. Chem. | volume = 272 | issue = 44 | pages = 27629–34 | year = 1997 | pmid = 9346901 | doi = 10.1074/jbc.272.44.27629 }}
  • {{cite journal | vauthors = Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG | title = Transcription factor-specific requirements for coactivators and their acetyltransferase functions | journal = Science | volume = 279 | issue = 5351 | pages = 703–7 | year = 1998 | pmid = 9445475 | doi = 10.1126/science.279.5351.703 }}
  • {{cite journal | vauthors = Shirazi SK, Bober MA, Coetzee GA | title = Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene) | journal = Clin. Genet. | volume = 54 | issue = 1 | pages = 102–3 | year = 1998 | pmid = 9727751 | doi = 10.1111/j.1399-0004.1998.tb03704.x }}
  • {{cite journal | vauthors = Wang JC, Stafford JM, Granner DK | title = SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4 | journal = J. Biol. Chem. | volume = 273 | issue = 47 | pages = 30847–50 | year = 1998 | pmid = 9812974 | doi = 10.1074/jbc.273.47.30847 | pmc = 3968904 }}
  • {{cite journal | vauthors = Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R | title = Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1 | journal = Genes Dev. | volume = 12 | issue = 22 | pages = 3488–98 | year = 1999 | pmid = 9832502 | pmc = 317237 | doi = 10.1101/gad.12.22.3488 }}
  • {{cite journal | vauthors = Chen H, Lin RJ, Xie W, Wilpitz D, Evans RM | title = Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase | journal = Cell | volume = 98 | issue = 5 | pages = 675–86 | year = 1999 | pmid = 10490106 | doi = 10.1016/S0092-8674(00)80054-9 }}
  • {{cite journal | vauthors = Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K, Imamura T | title = Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation | journal = J. Cell Sci. | volume = 112 | issue = 20 | pages = 3519–27 | year = 2000 | pmid = 10504300 | doi = }}
  • {{cite journal | vauthors = Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM | title = Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2 | journal = Mol. Endocrinol. | volume = 13 | issue = 12 | pages = 2151–62 | year = 2000 | pmid = 10598588 | doi = 10.1210/me.13.12.2151 }}
  • {{cite journal | vauthors = Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM | title = CBP/p300 interact with and function as transcriptional coactivators of BRCA1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 3 | pages = 1020–5 | year = 2000 | pmid = 10655477 | pmc = 15508 | doi = 10.1073/pnas.97.3.1020 }}
  • {{cite journal | vauthors = Leo C, Li H, Chen JD | title = Differential mechanisms of nuclear receptor regulation by receptor-associated coactivator 3 | journal = J. Biol. Chem. | volume = 275 | issue = 8 | pages = 5976–82 | year = 2000 | pmid = 10681591 | doi = 10.1074/jbc.275.8.5976 }}
  • {{cite journal | vauthors = Font de Mora J, Brown M | title = AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5041–7 | year = 2000 | pmid = 10866661 | pmc = 85954 | doi = 10.1128/MCB.20.14.5041-5047.2000 }}
  • {{cite journal | vauthors = Tan JA, Hall SH, Petrusz P, French FS | title = Thyroid receptor activator molecule, TRAM-1, is an androgen receptor coactivator | journal = Endocrinology | volume = 141 | issue = 9 | pages = 3440–50 | year = 2000 | pmid = 10965917 | doi = 10.1210/endo.141.9.7680 }}
{{refend}}{{PDB Gallery|geneid=8202}}{{Transcription coregulators}}

2 : Transcription coregulators|PAS-domain-containing proteins
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