O16 or O-16 may refer to:

• Garberville Airport FAA LID, a public airport located two miles (3.2 km) south-west of Garberville, a town in Humboldt County, California, USA
• O-16 observation aircraft of the United States Army Air Corps, a version of the Curtiss Falcon
• USS O-16 (SS-77), a United States Navy O class submarine
• O 16 a submarine of the Royal Netherlands Navy
• Oxygen-16, an isotope of oxygen

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