| 词条 | Olanzapine/fluoxetine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 447722434 | image = Olanzapine and fluoxetine.svg | type = combo | component1 = Olanzapine | class1 = Atypical antipsychotic | component2 = Fluoxetine | class2 = Selective serotonin reuptake inhibitor | tradename = Symbyax, Cinol Forte, Cinol Plus, Depten-OZ, M-Olan Plus, Oladay-F, Olanex-F, Olapin Forte, Olapin Plus, Olorest-F | Drugs.com = {{Drugs.com|parent|Symbyax}} | pregnancy_AU = C | pregnancy_US = C | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Rx-only | legal_status = not controlled | routes_of_administration = Oral | ATCvet = | ATC_prefix = N06 | ATC_suffix = CA03 | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = D10206 }}Olanzapine/fluoxetine (trade name Symbyax, created by Eli Lilly and Company) is a single capsule containing the atypical antipsychotic olanzapine and the selective serotonin reuptake inhibitor (SSRI) fluoxetine. Olanzapine/fluoxetine is primarily used to treat the depressive episodes of bipolar I disorder as well as treatment-resistant depression.[1] Medical usesOlanzapine/fluoxetine was approved by the U.S. Food and Drug Administration (FDA) to treat the depressive episodes of bipolar I disorder in 2003.[1] In 2009, it was granted approval for the treatment of treatment-resistant depression.[2] Olanzapine/fluoxetine, or other antidepressant/antipsychotic combinations, are sometimes prescribed off-label for anxiety disorders,[3] eating disorders,[4] obsessive–compulsive disorder (OCD),[5] and posttraumatic stress disorder (PTSD).[6] Side effectsPossible side effects of olanzapine/fluoxetine include all those of the two component drugs: olanzapine and fluoxetine. Common side effects include suicidal thoughts, increased appetite, weight gain, drowsiness, fatigue, dry mouth, swelling, tremor, blurred vision, and difficulty concentrating.[1] Olanzapine/fluoxetine could produce a severe allergic reaction and should not be used if the patient has previously experienced an allergic reaction to either fluoxetine or olanzapine.[7] Olanzapine is correlated with an increase in blood sugar. Patients with diabetes, or those at risk for developing it, require careful monitoring.[7] In rare cases, olanzapine/fluoxetine may cause neuroleptic malignant syndrome.[1] Like other SSRIs, olanzapine/fluoxetine carries a boxed warning stating that it could increase the risk of suicidal thoughts and behaviors in patients aged 24 and under. The warning also states that olanzapine/fluoxetine may increase the risk of death in elderly patients with dementia-related psychosis.[1] See also
References1. ^1 2 3 4 {{cite web | title = Symbyax Prescribing Information | publisher = Eli Lilly and Company | date = 2010 | url = http://pi.lilly.com/us/symbyax-pi.pdf}} 2. ^{{cite web | author = Grohol, J. | title = FDA Approves Symbyax for Treatment Resistant Depression | work = Psych Central Blog | url = http://psychcentral.com/blog/archives/2009/03/23/fda-approves-symbyax-for-treatment-resistant-depression/}} 3. ^{{cite journal |vauthors=McIntyre R, Katzman M |title=The role of atypical antipsychotics in bipolar depression and anxiety disorders. |journal=Bipolar Disord. |year=2003 |pmid=14700010 |volume=5 Suppl 2 |pages=20–35 |doi=10.1111/j.1399-2406.2003.00061.x}} 4. ^{{cite journal |vauthors=Pederson KJ, Roerig JL, Mitchell JE |title=Towards the pharmacotherapy of eating disorders |journal=Expert Opin. Pharmacother. |volume=4 |issue=10 |pages=1659–78 |year=2003 |pmid=14521477 |doi=10.1517/14656566.4.10.1659}} 5. ^{{cite journal |vauthors=Koran LM, Ringold AL, Elliott MA |title=Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder |journal=J Clin Psychiatry |volume=61 |issue=7 |pages=514–7 |year=2000 |pmid=10937610 |doi=10.4088/JCP.v61n0709}} 6. ^{{cite journal |vauthors=Stein MB, Kline NA, Matloff JL |title=Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study |journal=Am J Psychiatry |volume=159 |issue=10 |pages=1777–9 |year=2003 |pmid=12359687 |doi=10.1176/appi.ajp.159.10.1777}} 7. ^1 Drugs.com https://www.drugs.com/pdr/symbyax.html External links
| title = Pharmacodynamics | titlestyle = background:#ccccff | list1 ={{Adrenergic receptor modulators}}{{Dopamine receptor modulators}}{{Histamine receptor modulators}}{{Monoamine reuptake inhibitors}}{{Muscarinic acetylcholine receptor modulators}}{{Serotonin receptor modulators}} }}{{OCD pharmacotherapies}}{{DEFAULTSORT:Olanzapine fluoxetine}} 9 : Dopamine antagonists|Muscarinic antagonists|Selective serotonin reuptake inhibitors|Serotonin antagonists|Atypical antipsychotics|Antidepressants|Eli Lilly and Company|Mood stabilizers|Combination drugs |
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