| 词条 | Olfactory marker protein |
| 释义 |
| Name = olfactory marker protein | caption = | image = | width = | HGNCid = 8136 | Symbol = OMP | AltSymbols = | EntrezGene = 4975 | OMIM = 164340 | RefSeq = NM_006189 | UniProt = P47874 | PDB = | ECnumber = | Chromosome = 11 | Arm = q | Band = 14 | LocusSupplementaryData = -q21 }}{{Infobox protein family | Symbol = Olfactory_mark | Name = Olfactory marker protein | image = PDB 1jyt EBI.jpg | width = | caption = solution structure of olfactory marker protein from rat | Pfam = PF06554 | Pfam_clan = | InterPro = IPR009103 | SMART = | PROSITE = | MEROPS = | SCOP = 1jyt | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, olfactory marker protein is a protein involved in signal transduction. It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology.[1] Three highly conserved regions have been identified as possible protein–protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch.[2] External links
References1. ^{{cite journal |vauthors=Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL | title = Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction | journal = J. Mol. Biol. | volume = 319 | issue = 3 | pages = 823–37 |date=June 2002 | pmid = 12054873 | doi = 10.1016/S0022-2836(02)00282-6 | url = }} {{InterPro content|IPR009103}}{{Nerve tissue protein}}{{gene-11-stub}}2. ^{{cite journal |vauthors=Smith PC, Firestein S, Hunt JF | title = The crystal structure of the olfactory marker protein at 2.3 A resolution | journal = J. Mol. Biol. | volume = 319 | issue = 3 | pages = 807–21 |date=June 2002 | pmid = 12054872 | doi = 10.1016/S0022-2836(02)00242-5 | url = }} 1 : Protein families |
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