| Season | European Competitions | French Cup | French League Cup |
| 1959–60 | Inter-Cities Fairs Cup
First round: Internazionale: 0 – 7 / 1 – 1 | – | – |
| 1960–61 | Inter-Cities Fairs Cup First round: 1. FC Köln: 1 – 3 / 2 – 1 | – | – |
| 1961–62 | Inter-Cities Fairs Cup
First round: Sheffield Wednesday: 4 – 2 / 2 – 5 | – | – |
| 1962–63 | – | : Lyon 2 – Marseille 1
QF: Lyon 1 – Sedan 0
SF: Lyon 3 – Toulon 1
Final: Monaco 2 – Lyon 0 (a.e.t.) | – |
| 1963–64 | Cup Winners' Cup
First round: Odense: 3 – 1 / 3 – 1
Second round: Olympiacos : 4 – 1 / 1 – 2
QF: Hamburg: 1 – 1 / 2 – 0
SF: Sporting CP: 0 – 0 / 1 – 1 / 0 –1 | Round of 16: Lyon 3 – Cherbourg 0
QF: Lyon 2 – Lens 1
SF: Lyon 2 – Valenciennes 0
Final: Lyon 2 – Bordeaux 0 | – |
| 1964–65 | Cup Winners' Cup
First round: Porto : 0 – 3 / 0 –1 | – | – |
| 1966–67 | – | Round of 16: Lyon 1 – Rouen 0
QF: Lyon 1 – Angers 0
SF: Lyon – Angoulême: 3–3 ; 1–1 ; Lyon wins (coin)
Final: Lyon 3 – Sochaux 1 | - |
| 1967–68 | Cup Winners' Cup
First round: Aris Bonnevoie: 3 – 0 / 2 –1
Second round: Tottenham Hotspur: 1 – 0 / 3 – 4
QF: Hamburger SV: 0 – 2 / 2 – 0 / 0 – 2 | – | – |
| 1968–69 | Inter-Cities Fairs Cup
First round: Académica de Coimbra: 1 – 0 / 1 – 0
Second round: Vitória de Setúbal: 0 – 5 / 1 – 2 | – | – |
| 1970–71 | – | Round of 16: Saint-Étienne – Lyon: 2–0 ; 0–3
QF: Lyon – Dunkerque: 3–1 ; 3–2
SF: Sochaux –Lyon: 0–1 ; 1–1
Final: Rennes 1 – Lyon 0 | - |
| 1972–73 | – | Round of 16: Lyon – Bordeaux: 3–0 ; 1–3
QF: Marseille – Lyon: 1–0 ; 0–4
SF: Avignon – Lyon: 1–0 ; 1–4
Final: Lyon 2 – Nantes 1 | - |
| 1973–74 | Cup Winners' Cup
First round: Lahti: 0 – 0 / 2 – 0
Second round: PAOK : 3 – 3 / 0 – 4 | Round of 16: Cannes –Lyon : 1–2 ; 1–5
QF: Lyon –Sochaux 4–2 ; 0–2 (3–4) | – |
| 1974–75 | UEFA Cup
First round: Differdange: 7 – 0 / 4 – 1
Second round: Borussia Mönchengladbach: 0 – 1 / 2 – 5 | – | – |
| 1975–76 | UEFA Cup
First round: Club Brugge : 4 – 3 / 0 – 3 | Round of 16: Lille – Lyon : 0–2 ; 0–4
QF: Paris Saint-Germain – Lyon : 1–1 ; 0–2
SF: Lyon 2 – Metz 0
Final : Marseille 2 – Lyon 0 | - |
| 1981–82 | - | QF: Bastia –Lyon : 2–0 ; 2–3 | – |
| 1982–83 | – | QF: Tours –Lyon : 2–0 ; 2–3 | - |
| 1983–84 | - | QF: FC Nantes –Lyon : 0–0 ; 4–4 | – |
| 1986–87 | – | QF: Marseille –Lyon : 3–0 ; 2–2 | - |
| 1988–89 | - | QF: Sochaux –Lyon : 1–0 ; 1–1 | – |
| 1991–92 | UEFA Cup
1/32 : Östers IF Växjö : 1 – 1 / 1 – 0
1/16 : Trabzonspor : 3 – 4 / 1 – 4 | – | – |
| 1995–96 | UEFA Cup
1/32 : Farense : 1 – 0 / 1 –0
1/16 : Lazio : 2 – 1 / 2 –0
1/8 : Nottingham Forest : 0 –1 / 0 – 0 | – | 1/8 : Lyon 3 – Amiens 1
1/4 : Lyon 1 – Monaco 0
1/2 : Lyon 1 – Cannes 0
Final : Metz 0 – Lyon 0 (5–4 pen) |
| 1996–97 | - | – | 1/8 : Rennes 4 – Lyon 3 |
| 1997–98 | UEFA Cup
1/32 : Brøndby : 4– 1 / 3 – 2
1/16 : Internazionale: 2 – 1 / 1 – 3 | 1/8 : Istres 0 –Lyon 1
1/4 : Bourg-Péronnas 0 –Lyon 1
1/2 : Lens 2 –Lyon 0 | - |
| 1998–99 | UEFA Cup
1/32 : Blackburn Rovers : 1 – 0 / 2 –2
1/16 : Red Star Belgrade : 2 – 1 / 3 –2
1/8 : Club Brugge : 1 – 0 / 4 – 3
1/4 : Bologna; 0 –3 / 2 –0 | – | - |
| 1999–2000 | UEFA Champions League + UEFA Cup
3rd pre round : Maribor : 0– 1 / 0- 2
1/32 (UEFA) : HJK: 1 – 0 / 5- 1
1/16 (UEFA) : Celtic : 1 – 0 / 1 – 0
1/8 (UEFA) : Werder Bremen : 3 – 0 / 0 – 4 | 1/8 : Red Star Paris 1–2 Lyon
1/4 : Lyon 1–3 Monaco | 1/8 : Lyon 1 – Bordeaux 0
1/4: Lyon 0 – Bastia 1 |
| 2000–01 | UEFA Champions League
3rd pre round : Inter Bratislava : 2–1 / 2–1
1st round : Heerenveen: 3–1 ; 2–0
Olympiacos 1–2 ; 1–0
Valencia 0–1 ; 1–2
2nd round: Bayern Munich 0–1 ; 3–0
Spartak Moscow 3–0 ; 1–1
Arsenal 0–1 ; 1–1 | – | 1/8 : Lens 1 – Lyon 3
1/4 : Amiens 0 – Lyon 2
1/2 : Lyon 3 – Nantes 2
Final : Monaco 1 – Lyon 2 |
| 2001–02 | UEFA Champions League + UEFA Cup
1st round (CL) : Bayer Leverkusen: 0–1 / 4–2
Fenerbahçe 1–0 ; 3–1 / Barcelona 0–2 ; 2–3
1/16 (UEFA) : Club Brugge : 1–4 / 3–0
1/8 (UEFA) : Slovan Liberec : 1–1 / 1–4 | – | 1/8: Bordeaux 1 – Lyon 1 (4-2 pen) |
| 2002–03 | UEFA Champions League + UEFA Cup
1st round (CL) : Ajax 1–2 ; 0–2
Rosenborg 5–0 ; 1–1 / Internazionale 2–1 ; 3–3
1/16 (UEFA) : Denizlispor 0–0 ; 0–1 | – | 1/8: Sochaux 3 – Lyon 3 (5-3 pen) |
| 2003–04 | UEFA Champions League
Group stage: Anderlecht : 1–0 ; 0–1
Celtic : 2–0 ; 2–3
Bayern Munich : 1–1 ; 2–1
1/8: Real Sociedad : 1–0 ; 1–0
1/4 : Porto : 0 –2, 2 –2 | 1/8: Monaco 4 – Lyon 1 | - |
| 2004–05 | UEFA Champions League
Group stage: Manchester United: 2– 2 ; 1–2
Fenerbahçe: 3–1 ; 4–2
Sparta Prague 2-1 ; 5-0
1/8: Werder Bremen: 3–0 ; 7–2
1/4: PSV : 1–1 ; 1–1 (4–2 pen) | – | – |
| 2005–06 | UEFA Champions League
Group stage: Real Madrid : 3–0 ; 1–1
Rosenborg 1–0; 2–1
Olympiacos 2–1 ; 4–1
1/8 : PSV : 1–0 ; 4–0
1/4 : Milan: 0–0 ; 1–3 | – | - |
| 2006–07 | UEFA Champions League
Group stage: Real Madrid : 2–0; 2–2
Steaua București : 3–0; 1–1
Dynamo Kyiv : 3–0 ; 1–0
1/8 : Roma : 0–0 ; 0–2 | – | 1/8 : Lyon 2 – Paris Saint-Germain 1
1/4 : Lyon 3 – Nancy 1
1/2 : Lyon 1 – Le Mans 0
Final : Bordeaux 1 – Lyon 0 |
| 2007–08 | UEFA Champions League
Group stage: Rangers: 0–3 ; 3–0
VfB Stuttgart : 2–0 ; 4–2
Barcelona : 0–3 ; 2–2
1/8 Manchester United: 1–1 ; 0–1 | 1/8 Lyon 2 – Sochaux 1
1/4 Lyon 1 –Metz 0
1/2 Lyon 1 – Sedan 0
Final: Paris Saint-Germain 0 – Lyon 1 | 1/8: Caen 1 – Lyon 3
1/4: Le Mans 1 – Lyon 0 |
| 2008–09 | UEFA Champions League
Group stage: Fiorentina: 2–2; 2–1
Bayern Munich : 1–1; 2–3
Steaua București : 5–3; 2–0
1/8 Barcelona: 1–1; 2–5 | – | 1/8: Lyon 1 – Metz 3
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| 2009–10 | UEFA Champions League
Group stage: Fiorentina: 1–0; 0–1
Liverpool: 1–1; 1–2
Debrecen: 4–0; 4–0
1/8: Real Madrid: 1–0: 1–1
1/4: Bordeaux: 3–1; 0–1
1/2: Bayern Munich: 0–3; 0–1 | – | 1/8: Lyon 3 – Metz 0
1/4: Lorient 1 – Lyon 0 |