| 词条 | Omegaven |
| 释义 |
Omegaven is a fatty acid emulsion produced by Fresenius Kabi. It is used for total parenteral nutrition (feeding directly into a venous catheter), e.g. in short bowel syndrome. It is rich in omega-3 fatty acids. It has gained popularity in children in preference to the more commonly used Intralipid after case reports that it reduced the risk of liver damage.[1] A recent study indicated that the use of Omegaven may be an appropriate intervention strategy for newborns with a very low birth weight, gastrochisis, and jejunal atresia.[2] It is currently undergoing a clinical trial at National Taiwan University Hospital.[3] Although the use of Omegaven in children in the United States is experimental, the use of it in adults in Europe is less controversial.[4] In European studies, Omegaven has been associated with a reduction in psoriasis, when contrasted to administration of omega-6 fatty acid Lipoven.[5] Omegaven has also been associated with reduced mortality and antibiotic use during hospital stays.[6] Omegaven was approved for use in the United States on, July 27, 2018, and is now available to patients on the US market by prescription effective November 15, 2018.[7] References1. ^{{cite journal |vauthors=Gura KM, Duggan CP, Collier SB, etal |title=Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management |journal=Pediatrics |volume=118 |issue=1 |pages=e197–201 |year=2006 |pmid=16818533 |doi=10.1542/peds.2005-2662}} 2. ^{{cite journal |vauthors=Christensen RD, Henry E, Wiedmeier SE, Burnett J, Lambert DK |title=Identifying patients, on the first day of life, at high-risk of developing parenteral nutrition-associated liver disease |journal=Journal of Perinatology |volume=27 |issue=5 |pages=284–90 |year=2007 |pmid=17344923 |doi=10.1038/sj.jp.7211686}} 3. ^{{ClinicalTrialsGov|NCT00172198}} 4. ^A Doctor's Push For Drug Pits Him Against Its Maker at Wall Street Journal 5. ^{{cite journal |vauthors=Mayser P, Grimm H, Grimminger F |title=n-3 fatty acids in psoriasis |series=87 |journal=Br. J. Nutr. |volume=Suppl 1 |issue= |pages=S77–82 |year=2002 |pmid=11895157 |doi=10.1079/bjn2001459}} 6. ^{{cite journal |vauthors=Heller AR, Rössler S, Litz RJ, etal |title=Omega-3 fatty acids improve the diagnosis-related clinical outcome |journal=Crit. Care Med. |volume=34 |issue=4 |pages=972–9 |year=2006 |pmid=16484909 |doi=10.1097/01.CCM.0000206309.83570.45}} 7. ^{{Cite web|url=https://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/InvestigationalNewDrugINDApplication/ucm368740.htm|title=Investigational New Drug (IND) Application - How to request Omegaven for Expanded Access Use|last=Research|first=Center for Drug Evaluation and|website=www.fda.gov|language=en|access-date=2019-02-15}} External links
5 : Intensive care medicine|Hepatology|Gastroenterology|Pediatrics|Malnutrition |
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