“Opine dehydrogenase”的意思、由来-开放百科全书

词条

Opine dehydrogenase

释义

References

{{enzyme
| Name = opine dehydrogenase
| EC_number = 1.5.1.28
| CAS_number = 108281-02-3
| IUBMB_EC_number = 1/5/1/28
| GO_code = 0047129
| image =
| width =
| caption =
}}

In enzymology, an opine dehydrogenase ({{EC number|1.5.1.28}}) is an enzyme that catalyzes the chemical reaction

(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate + NAD⁺ + H₂O L-2-aminopentanoic acid + pyruvate + NADH + H⁺

The 3 substrates of this enzyme are {[1-(R)-carboxyethyl]amino}pentanoate">(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate, NAD⁺, and H₂O, whereas its 4 products are L-2-aminopentanoic acid, pyruvate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming). Other names in common use include (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD+,, and L-aminopentanoate-forming).

References

{{cite journal | vauthors = Asano Y, Yamaguchi K, Kondo K | date = 1989 | title = A new NAD+-dependent opine dehydrogenase from Arthrobacter sp strain 1C | journal = J. Bacteriol. | volume = 171 | pages = 4466–71 | pmid = 2753861 | issue = 8 | pmc = 210226 }}
{{cite journal | vauthors = Dairi T, Asano Y | date = 1995 | title = Cloning, nucleotide sequencing, and expression of an opine dehydrogenase gene from Arthrobacter sp. strain 1C | journal = Appl. Environ. Microbiol. | volume = 61 | pages = 3169–71 | pmid = 7487048 | issue = 8 | pmc = 167592 }}
{{cite journal | vauthors = Kato Y, Yamada H, Asano Y | date = 1996 | title = Stereoselective synthesis of opine-type secondary amine carboxylic acids by a new enzyme opine dehydrogenase. Use of recombinant enzymes | journal = J. Mol. Catal., B Enzym. | volume = 1 | pages = 151–160 | doi = 10.1016/1381-1177(95)00011-9 | issue = 3–6 }}

3 : EC 1.5.1|NADH-dependent enzymes|Enzymes of unknown structure

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