| 词条 | PB-28 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 426027785 | Name = PB-28 | ImageFile = PD28.png | ImageSize = 250px | ImageName = PB28 | IUPACName = 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetra- hydronaphthalen-1-yl)propyl]piperazine | OtherNames = PB28 | Section1 = {{Chembox Identifiers | IUPHAR_ligand = 6681 | CASNo_Ref = {{cascite|correct|??}} | CASNo =172906-90-0 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 53325 | SMILES = COc1c(CCCC2CCCN3CCN(C4CCCCC4)CC3)c2ccc1 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 8649746 | InChI = 1/C24H38N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3 | InChIKey = PHRCDWVPTULQMT-UHFFFAOYAW | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C24H38N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = PHRCDWVPTULQMT-UHFFFAOYSA-N | RTECS = | MeSHName = C097775 | Section2 = {{Chembox Properties | Formula = C24H38N2O | MolarMass = 370.57 g/mol }}PB-28[1] is an agonist of the sigma-2 receptor.[2][3][4][5][6] It is derived from cyclohexylpiperazine. References1. ^{{cite journal | vauthors = Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L | title = New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives | journal = J. Med. Chem. | volume = 39 | issue = 1 | pages = 176–82 | year = 1996 | pmid = 8568804 | doi = 10.1021/jm950409c | issn = }} 2. ^{{cite journal | vauthors = Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA | title = The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells | journal = Cell Calcium | volume = 40 | issue = 1 | pages = 23–8 | year = 2006 | pmid = 16687172 | doi = 10.1016/j.ceca.2006.03.004 | issn = }} 3. ^{{cite journal | vauthors = Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A | title = Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer | journal = Mol. Cancer Ther. | volume = 5 | issue = 7 | pages = 1807–16 | year = 2006 | pmid = 16891467 | doi = 10.1158/1535-7163.MCT-05-0402 | issn = | url = http://mct.aacrjournals.org/content/molcanther/5/7/1807.full.pdf }} 4. ^{{cite journal |vauthors=Colabufo NA, Berardi F, Abate C, Contino M, Niso M, Perrone R |title=Is the sigma2 receptor a histone binding protein? |journal=Journal of Medicinal Chemistry |volume=49 |issue=14 |pages=4153–8 |date=July 2006 |pmid=16821775 |doi=10.1021/jm0600592 |url=}} 5. ^{{cite journal |vauthors=Berardi F, Abate C, Ferorelli S, Uricchio V, Colabufo NA, Niso M, Perrone R |title=Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) |journal=Journal of Medicinal Chemistry |volume=52 |issue=23 |pages=7817–28 |date=December 2009 |pmid=19842660 |doi=10.1021/jm9007505 |url=}} 6. ^{{cite journal |vauthors=Abate C, Elenewski J, Niso M, Berardi F, Colabufo NA, Azzariti A, Perrone R, Glennon RA |title=Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer |journal=ChemMedChem |volume=5 |issue=2 |pages=268–73 |date=February 2010 |pmid=20077462 |doi=10.1002/cmdc.200900402 |url=}} External links
2 : Phenol ethers|Piperazines |
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