| 释义 |
- Interactions
- References
- Further reading
- External links
{{Infobox_gene}}Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[1] Interactions PBX1 has been shown to interact with: - HOXB1,[2][3]
- HOXB7,[4]
- MEIS1,[5][6][7] and
- Prep1.[8]
References 1. ^{{cite web | title = Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5087| accessdate = }}
2. ^{{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1434–45 | date = Mar 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}
3. ^{{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–97 | date = Feb 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5}}
4. ^{{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes & Development | volume = 9 | issue = 6 | pages = 663–74 | date = Mar 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663}}
5. ^{{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi = }}
6. ^{{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi = }}
7. ^{{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 | doi = }}
8. ^{{cite journal | vauthors = Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K | title = Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1 | journal = Molecular and Cellular Biology | volume = 26 | issue = 11 | pages = 4111–21 | date = Jun 2006 | pmid = 16705164 | pmc = 1489093 | doi = 10.1128/MCB.00222-06 }}
{{clear}} Further reading {{refbegin|33em}}- {{cite journal | vauthors = Sanyal M, Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL, Herzenberg LA, Cleary ML | title = B-cell development fails in the absence of the Pbx1 proto-oncogene | journal = Blood | volume = 109 | issue = 10 | pages = 4191–9 | date = May 2007 | pmid = 17244677 | pmc = 1885499 | doi = 10.1182/blood-2006-10-054213 }}
- {{cite journal | vauthors = Hui H, Perfetti R | title = Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood | journal = European Journal of Endocrinology / European Federation of Endocrine Societies | volume = 146 | issue = 2 | pages = 129–41 | date = Feb 2002 | pmid = 11834421 | doi = 10.1530/eje.0.1460129 }}
- {{cite journal | vauthors = Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP, Cleary ML | title = The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias | journal = Blood | volume = 77 | issue = 4 | pages = 687–93 | date = Feb 1991 | pmid = 1671560 | doi = }}
- {{cite journal | vauthors = Monica K, Galili N, Nourse J, Saltman D, Cleary ML | title = PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 | journal = Molecular and Cellular Biology | volume = 11 | issue = 12 | pages = 6149–57 | date = Dec 1991 | pmid = 1682799 | pmc = 361792 | doi = 10.1128/mcb.11.12.6149}}
- {{cite journal | vauthors = Nourse J, Mellentin JD, Galili N, Wilkinson J, Stanbridge E, Smith SD, Cleary ML | title = Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor | journal = Cell | volume = 60 | issue = 4 | pages = 535–45 | date = Feb 1990 | pmid = 1967982 | doi = 10.1016/0092-8674(90)90657-Z }}
- {{cite journal | vauthors = Kamps MP, Murre C, Sun XH, Baltimore D | title = A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL | journal = Cell | volume = 60 | issue = 4 | pages = 547–55 | date = Feb 1990 | pmid = 1967983 | doi = 10.1016/0092-8674(90)90658-2 }}
- {{cite journal | vauthors = Lu Q, Wright DD, Kamps MP | title = Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation | journal = Molecular and Cellular Biology | volume = 14 | issue = 6 | pages = 3938–48 | date = Jun 1994 | pmid = 7910944 | pmc = 358760 | doi = 10.1128/mcb.14.6.3938}}
- {{cite journal | vauthors = Van Dijk MA, Voorhoeve PM, Murre C | title = Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 13 | pages = 6061–5 | date = Jul 1993 | pmid = 8327485 | pmc = 46867 | doi = 10.1073/pnas.90.13.6061 }}
- {{cite journal | vauthors = Lu Q, Kamps MP | title = Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex | journal = Molecular and Cellular Biology | volume = 16 | issue = 4 | pages = 1632–40 | date = Apr 1996 | pmid = 8657138 | pmc = 231149 | doi = 10.1128/mcb.16.4.1632}}
- {{cite journal | vauthors = Berthelsen J, Zappavigna V, Mavilio F, Blasi F | title = Prep1, a novel functional partner of Pbx proteins | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1423–33 | date = Mar 1998 | pmid = 9482739 | pmc = 1170490 | doi = 10.1093/emboj/17.5.1423 }}
- {{cite journal | vauthors = Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F | title = The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1434–45 | date = Mar 1998 | pmid = 9482740 | pmc = 1170491 | doi = 10.1093/emboj/17.5.1434 }}
- {{cite journal | vauthors = Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C | title = Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation | journal = Cell | volume = 96 | issue = 4 | pages = 587–97 | date = Feb 1999 | pmid = 10052460 | doi = 10.1016/S0092-8674(00)80662-5 }}
- {{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi = }}
- {{cite journal | vauthors = Jacobs Y, Schnabel CA, Cleary ML | title = Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5134–42 | date = Jul 1999 | pmid = 10373562 | pmc = 84356 | doi = }}
- {{cite journal | vauthors = Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP | title = A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1 | journal = Nucleic Acids Research | volume = 27 | issue = 18 | pages = 3752–61 | date = Sep 1999 | pmid = 10471746 | pmc = 148632 | doi = 10.1093/nar/27.18.3752 }}
- {{cite journal | vauthors = McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C | title = Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11464–9 | date = Sep 1999 | pmid = 10500199 | pmc = 18056 | doi = 10.1073/pnas.96.20.11464 }}
- {{cite journal | vauthors = Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS | title = PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7577–88 | date = Nov 1999 | pmid = 10523646 | pmc = 84774 | doi = }}
- {{cite journal | vauthors = Mikkola I, Bruun JA, Holm T, Johansen T | title = Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins | journal = The Journal of Biological Chemistry | volume = 276 | issue = 6 | pages = 4109–18 | date = Feb 2001 | pmid = 11069920 | doi = 10.1074/jbc.M008882200 }}
- {{cite journal | vauthors = Thameem F, Wolford JK, Bogardus C, Prochazka M | title = Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians | journal = Biochimica et Biophysica Acta | volume = 1518 | issue = 1-2 | pages = 215–20 | date = Mar 2001 | pmid = 11267683 | doi = 10.1016/S0167-4781(01)00189-0 }}
- {{cite journal | vauthors = Liu Y, MacDonald RJ, Swift GH | title = DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 17985–93 | date = May 2001 | pmid = 11279116 | doi = 10.1074/jbc.M100678200 }}
- {{cite journal | vauthors = Mal A, Sturniolo M, Schiltz RL, Ghosh MK, Harter ML | title = A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program | journal = The EMBO Journal | volume = 20 | issue = 7 | pages = 1739–53 | date = Apr 2001 | pmid = 11285237 | pmc = 145490 | doi = 10.1093/emboj/20.7.1739 }}
{{refend}} External links - {{MeshName|PBX1+protein,+human}}
{{PDB Gallery|geneid=5087}}{{Transcription factors|g3}} 1 : Transcription factors |