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词条 Pegylated interferon
释义

  1. References

Pegylated interferon (PEG-INF) is a class of medication that includes three different drugs as of 2012:[1]
  • Pegylated interferon-alpha-2a
  • Pegylated interferon-alpha-2b
  • Pegylated interferon-beta-1a[2]

In these formulations, Polyethylene glycol (PEG) is added to make interferon last longer in the body.[3] They are used to treat both hepatitis B,[4] hepatitis C[1] and multiple sclerosis.

Pegylated interferon is contraindicated in patients with hyperbilirubinaemia.

References

1. ^{{cite book|last=editor|first=Emilio Jirillo,|title=Hepatitis C virus disease : immunobiology and clinical applications|year=2008|publisher=Springer|location=New York|isbn=978-0-387-71375-5|pages=237|url=https://books.google.com/books?id=yjzazAgMWEUC&pg=PA237|edition=[Online-Ausg.]}}
2. ^{{cite journal |author=Kieseier BC, Calabresi PA. |title=PEGylation of Interferon-β-1a: A Promising Strategy in Multiple Sclerosis |url=http://adisonline.com/cnsdrugs/Abstract/2012/26030/PEGylation_of_Interferon___1a__A_Promising.2.aspx |archive-url=https://archive.is/20130101231543/http://adisonline.com/cnsdrugs/Abstract/2012/26030/PEGylation_of_Interferon___1a__A_Promising.2.aspx |dead-url=yes |archive-date=2013-01-01 |journal=CNS Drugs |volume=26 |issue=3 |pages=205–14 |year=2012 |doi=10.2165/11596970-000000000-00000 |pmid=22201341 |last2=Calabresi }}
3. ^{{cite web|url=http://www.medscape.com/viewarticle/407963_5|title= Hepatology Focus: Update on Hepatitis C Treatment: Pegylated Interferon|vauthors = Martin P|date=February 15, 2001|website=medscape}}
4. ^{{cite book|vauthors = Dancygier H, Allescher HD|title=Clinical Hepatology|year=2010|publisher=Springer Berlin Heidelberg|location=[S.l.]|isbn=978-3-642-04509-7|pages=765|url=https://books.google.com/books?id=lrPX8C4p90QC&pg=PA765}}
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3 : Antivirals|Immunostimulants|World Health Organization essential medicines

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