Perfect murder may refer to:

• Perfect murder, a murder that left no clue to trace the perpetrators
• Perfect murder (fiction), the fiction subgenre
• Perfect Murder, Perfect Town (film), 2000 film documenting the events behind and following the JonBenet Ramsey murder
• A Perfect Murder, 1998 remake of the 1954 film Dial M for Murder
• A Perfect Murder (band), a groove metal band
• "A Prefect Murder", an episode of the science fiction television series Farscape
• The Perfect Murder, a 1964 novel by H. R. F. Keating
  • The Perfect Murder (film), a 1988 English-language Indian film based on Keating's novel, produced by Merchant-Ivory
• The Perfect Murder (2014-), an American TV series about the murders committed in real life
• "The Perfect Murder" (short story), a short story written by Jeffrey Archer

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