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词条 Peter Dervan
释义

  1. Early life and education

  2. Career

  3. Research

  4. Awards

  5. Personal

  6. Selected publications

  7. References

  8. External links

{{Infobox scientist
| image = Peter B. Dervan 2017 DSC8599.JPG
| image_size =
| name = Peter B. Dervan
| birth_date = {{birth date and age|mf=yes|1945|06|28}}
| birth_place = Boston, Massachusetts, U.S.
| nationality = American
| field = Organic chemistry
| alma_mater = Boston College, Yale University
| work_institution = Yale, Stanford, Caltech
| thesis_title = The stereochemistry of the thermal rearrangements of trans- and cis-1,2-dialkenylcyclobutanes
| thesis_url = https://search.proquest.com/docview/47891156/
| thesis_year = 1973
| doctoral_advisor = Jerome A. Berson
| doctoral_students = Peter Schultz, Alanna Schepartz, Scott Strobel, Eric Kool, Laura Kiessling
| prizes = National Medal of Science (2006)
| spouse = Jacqueline Barton
}}{{external media | width = 210px | align = right | headerimage= | video1 = "Science is the most fun in the whole wide world", [https://www.nsf.gov/news/special_reports/medalofscience50/dervan-barton.jsp Medal of Science 50 Videos -- Peter Dervan and Jacqueline Barton], National Science Foundation }}Peter B. Dervan (born June 28, 1945) is the Bren Professor of Chemistry at the California Institute of Technology. The primary focus of his research is the development and study of small organic molecules that can sequence-specifically recognize DNA,[1] a field in which he is an internationally recognized authority.[2] The most important of these small molecules are pyrrole–imidazole polyamides.[3]

Dervan is credited with influencing "the course of research in organic chemistry through his studies at the interface of chemistry and biology" as a result of his work on "the chemical principles involved in sequence-specific recognition of double helical DNA".[4]

He is the recipient of many awards, including the National Medal of Science (2006).[5][6]

Early life and education

Peter B. Dervan was born on June 28, 1945 in Boston, Massachusetts.

Dervan received his B.S. degree from Boston College in 1967,[7] where professor Francis Bennett sparked his interest in synthetic organic chemistry.[5] He began graduate studies at the University of Wisconsin then moved with Jerome A. Berson's research group to Yale University where he completed his graduate research in physical organic chemistry,[9] studying ways in which chemical bonds are created and broken apart.[5] He received his Ph.D. degree from Yale in 1972, for The Stereochemistry of the Thermal Rearrangements of Trans-1,2-Dialkenylcyclobutanes and Cis-1,2-Dialkenylcyclobutanes.[3][4] He then became an NIH postdoctoral fellow at Stanford.[5]

Career

Dervan became an assistant professor of chemistry at Caltech in 1973,[5] joining John D. Roberts, Robert G. Bergman and Robert Ellsworth Ireland in the organic chemistry group.[3] He became an associate professor in 1979, and professor in 1982. He was appointed as the first Bren Professor of Chemistry in 1988.[6][5] He served as Chair of Caltech's Division of Chemistry and Chemical Engineering from 1994 to 1999.[18] Dervan has published more than 325 papers and taught hundreds of students.[9]

Dervan is a member of the National Academy of Sciences (1986),[7]

the American Academy of Arts and Sciences (1987),[8] and

the American Philosophical Society (2002).[9]

He is an elected member of the French Academy of Sciences (2000)[10]

and the Deutsche Akademie der Naturforscher Leopoldina (2004- ).[11]

Dervan is a co-founder and founding member of the Scientific Advisory Board for Gilead Sciences (1987).[12][13][14][15] He served on the Board of Directors for Beckman Coulter beginning in 1997.[16] He served as a Trustee of Yale University (2008-2017).[18][9] He serves as a member of the Board of Scientific Governors of The Scripps Research Institute.[17] In 2014, he presented the ACS Chemical Biology Lecture.[18] {{As of|2016}} he became chair of the scientific advisory board of the Robert A. Welch Foundation.[19]

Research

While teaching a class at Caltech in Advanced Organic Chemistry, Dervan came to a realization that would guide his future career: rather than working to "close" a classic problem that had been previously defined, he would seek to define and "open" a new research area that could be studied for many years.[3]

The problem he chose was molecular recognition in biological systems.[5] At the time, DNA sequencing was in its infancy and the human genome project was undreamt of. Dervan chose to apply ideas from synthetic chemistry to biology and the study of DNA, creating novel binding molecules to be used for DNA recognition.[3]

{{quote|"I would study weak noncovalent bonds in the most challenging of solvents, water. Therefore, the ‘synthetic objective’ would be the three dimensional assembly of multiple specific noncovalent bonds in aqueous media. Biological molecules, such as proteins or nucleic acids, would be my target and small molecule synthesis combined with physical characterization and the methods of biology would provide the experimental foundation. I would move from the gas phase world of hydrocarbon rearrangements to the aqueous world of nucleic acids and molecular recognition." [3]}}

By studying weak intermolecular interactions and creating creating novel synthetic molecules specific to particular DNA sequences, Dervan has been able to explore the complex biological systems underlying DNA's structure and function.[9] A human cell contains 35,000–50,000 genes, whose expression is controlled by the binding of protein transcription factors in the promoter region of each gene.[3] Through pioneering work in DNA recognition,[9] Dervan has determined many of the chemical principles underlying sequence-specific recognition of DNA,[3] and enabled researchers to better understand the mechanism of action of many anti-tumor, anti-viral and anti-biotic drugs.[6]

Dervan determined that small molecules could be synthesized and used to selectively bind DNA at the transcription factor/DNA interface, effectively rewriting the biological codes controlling transcription by acting on the promoters of selected genes.[5]

The creation of synthetic small molecules with affinities and sequence specificities for predetermined DNA sequences makes it possible to design cell-permeable molecules for the regulation of gene expression.[5]

The use of small molecules to regulate gene expression in living cells has possible application to human medicine.[3][20]

The most important of these small molecules are pyrrole–imidazole polyamides.[20][21] Dervan's lab has identified pairing rules to control the DNA sequence specificity of minor-groove binding polyamides that contain the aromatic ring amino acids hydroxypyrrole (Hp), imidazole (Im), and pyrrole (Py).[22][20][23]

Awards

Dervan has received a number of awards for both research and teaching,[5] including those listed below. He was awarded the 2006 National Medal of Science in 2007 from President George Bush at the White House for “his fundamental research contributions at the interface of organic chemistry and biology” as well as contributions to education and industry.[5][24][25][26] A minor planet has been named in his honor, (4314) Dervan.[27]

{{div col|colwidth=30em}}
  • Harrison Howe Award (1988)[28]
  • Arthur C. Cope Award (1993)[29]
  • Willard Gibbs Award (1993)[30]
  • Nichols Medal (1994), for "his outstanding contributions in the field of bioorganic chemistry through the design and synthesis of sequence-specific DNA cleaving molecules."[31]
  • Maison de la Chimie Foundation Prize (1996)[32]
  • Remsen Award (1998)[33][34]
  • Kirkwood Medal (1998), for “outstanding research contributions, theoretical or experimental, in the physical sciences.”[35]
  • Alfred Bader Award (1999)[36]
  • Max Tishler Prize (1999)[37]
  • Linus Pauling Award (1999)[38]
  • Richard C. Tolman Medal (1999)[39]
  • Tetrahedron Prize (2000)[40]
  • Harvey Prize (Israel) (2002)[41]
  • Ronald Breslow Award (2005)[42]
  • Wilbur Cross Medal (2005)[43]
  • Frank Westheimer Prize (2009)[44]
  • National Medal of Science (2006)[26][24]
{{div col end}}

Personal

In 1990, Dervan married Jacqueline Barton, a fellow chemist and professor at Caltech. He is the father Andrew, from a previous marriage, and Elizabeth, from his marriage with Barton.[45][35] All four hold degrees from Yale University.[46]

Selected publications

  • {{cite journal

| last1 = Nickols
| first1 = N. G.
| last2 = Dervan
| first2 = P. B.
| year = 2007
| title = Suppression of Androgen Receptor Mediated Gene Expression by a Sequence-Specific DNA Binding Polyamide
| journal = Proc. Natl. Acad. Sci. USA
| volume = 104
| issue = 25
| pages = 10418–10423
| doi = 10.1073/pnas.0704217104
| pmc = 1965528
| pmid = 17566103
}}
  • {{cite journal

| last1 = Yang
| first1 = F.
| last2 = Nickols
| first2 = N. G.
| last3 = Li
| first3 = B. C.
| last4 = Marinov
| first4 = G. K.
| last5 = Said
| first5 = J. W.
| last6 = Dervan
| first6 = P. B.
| year = 2013
| title = Antitumor Activity of a Pyrrole-imidazole Polyamide
| journal = Proc. Natl. Acad. Sci. USA
| volume = 110
| issue = 5
| pages = 1863–1868
| doi = 10.1073/pnas.1222035110
| pmc = 3562772
| pmid = 23319609
| url= http://authors.library.caltech.edu/37407/1/PNAS-2013-Yang-1863-8.pdf
}}

References

1. ^{{cite journal|last1=Dervan1986|first1=P.B.|title=Design of sequence-specific-DNA-binding molecules|journal=Science|date=1986|volume=232|issue=4749|pages=464–471|pmid=2421408|accessdate=|doi=10.1126/science.2421408}}
2. ^{{cite news|title=Caltech Chemist Peter Dervan to Deliver Lecture|url=http://www.southwestern.edu/live/news/10473-caltech-chemist-peter-dervan-to-deliver-lecture|accessdate=15 June 2017|work=Southwestern Newsroom|quote=“Professor Dervan is an internationally renowned chemist and recognized pioneer in chemical biology."}}
3. ^{{cite web|title=Peter B. Dervan|url=https://academictree.org/chemistry/peopleinfo.php?pid=52764|website=Chemistry Tree|accessdate=14 June 2017}}
4. ^{{cite thesis |url=https://search.proquest.com/docview/47891156/ |title=The stereochemistry of the thermal rearrangements of trans- and cis-1,2-dialkenylcyclobutanes |date=1973 |publisher=Yale University |degree=Ph.D. |last=Dervan |first=Peter Brendan |via=ProQuest |subscription=yes |oclc=418780449}}
5. ^1 2 3 4 5 {{cite web|title=Carl Shipp Marvel Lecturer 2002-03 - Peter B. Dervan|url=http://www.chemistry.illinois.edu/events/lectures/CS_Marvel_Lecture_Series_in_Organic_Chemistry/Peter_Dervan.html|website=The Department of Chemistry at the University of Illinois|accessdate=14 June 2017}}
6. ^1 {{cite journal|title=For Your Information|journal=Analytical Chemistry|date=30 May 2012|volume=60|issue=6|pages=379A|doi=10.1021/ac00157a715}}
7. ^{{cite journal|title=Chemists elected to National Academy of Sciences|journal=Chemical & Engineering News|date=5 May 1986|volume=64|issue=18|pages=6|doi=10.1021/cen-v064n018.p006a}}
8. ^{{cite journal|title=NEWS|journal=Analytical Chemistry|date=September 1988|volume=60|issue=18|pages=1029A|doi=10.1021/ac00169a711}}
9. ^{{cite web|title=Peter B. Dervan|url=http://www.amphilsoc.org/memhist/search?creator=Peter+Dervan&title=&subject=&subdiv=&mem=&year=&year-max=&dead=&keyword=&smode=advanced|website=American Philosophical Society|accessdate=14 June 2017}}
10. ^{{cite web|title=Peter Dervan|url=http://www.academie-sciences.fr/en/Liste-des-membres-de-l-Academie-des-sciences-/-D/peter-dervan.html|website=Institute de France Académie des Sciences|accessdate=14 June 2017}}
11. ^{{cite news|last1=Schnitzer-Ungefug|first1=Jutta|title=Deutsche Akademie der Naturforscher Leopoldina wählt neue Mitglieder Prof|url=https://idw-online.de/de/news84545|accessdate=14 June 2017|work=Informationsdienst Wissenschaft|date=December 8, 2004}}
12. ^{{cite book|last1=Jones|first1=Stephanie|title=The biotechnologists and the evolution of biotech enterprises in the USA and Europe|date=1992|publisher=Macmillan|location=Basingstoke|isbn=978-0333550212|page=39|url=https://books.google.com/books?id=ZPOxCwAAQBAJ&pg=PA39|accessdate=14 June 2017}}
13. ^{{cite news|last1=Patrick|first1=Margaret|title=Gilead Sciences: Investor’s Overview of a Leading Biotech Company|url=http://marketrealist.com/2015/08/gilead-sciences-investors-overview-leading-biotech-company/|accessdate=14 June 2017|work=Market Realist|date=August 19, 2015}}
14. ^{{cite web|title=gilead sciences inc (GILD:NASDAQ GS)|url=https://www.bloomberg.com/research/stocks/people/person.asp?personId=554985&privcapId=29002|website=Bloomberg|accessdate=14 June 2017}}
15. ^{{cite web|title=10-K405 GILEAD SCIENCES INC filed this Form 10-K405 on 03/31/1998|url=http://investors.gilead.com/phoenix.zhtml?c=69964&p=irol-SECText&TEXT=aHR0cDovL2FwaS50ZW5rd2l6YXJkLmNvbS9maWxpbmcueG1sP2lwYWdlPTcxOTk2MSZEU0VRPTEmU0VRPTIwJlNRREVTQz1TRUNUSU9OX1BBR0UmZXhwPSZzdWJzaWQ9NTc%3D|website=Investors - Gilead Sciences, Inc.|accessdate=14 June 2017}}
16. ^{{cite web|url=https://www.sec.gov/Archives/edgar/data/840467/000119312508062334/ddef14a.htm|title=DEF 14A 1 ddef14a.htm DEFINITIVE PROXY STATEMENT FOR BECKMAN COULTER, INC.|website=UNITED STATES SECURITIES AND EXCHANGE COMMISSION|accessdate=14 June 2017}}
17. ^{{cite web|title=Board of Scientific Governors|url=https://www.scripps.edu/about/leadership/governors.html|website=The Scripps Research Institute|accessdate=14 June 2017}}
18. ^{{cite web |url=http://www.divbiolchem.org/content/acscbawardees1.pdf |title=ACS Chemical Biology Lecture |accessdate=2014-01-15 |website= |publisher=Division of Biological Chemistry |date= }}
19. ^{{cite web|title=Peter B. Dervan|url=http://www.welch1.org/media/Conference-Bios/Dervan.pdf|website=Robert A. Welch Foundation|accessdate=14 June 2017}}
20. ^1 2 {{cite journal|last1=Dervan|first1=Peter B|last2=Edelson|first2=Benjamin S|title=Recognition of the DNA minor groove by pyrrole-imidazole polyamides|journal=Current Opinion in Structural Biology|date=June 2003|volume=13|issue=3|pages=284–299|doi=10.1016/S0959-440X(03)00081-2|url=http://www.sciencedirect.com/science/article/pii/S0959440X03000812|accessdate=15 June 2017}}
21. ^{{cite journal|last1=Dervan|first1=PB|last2=Edelson|first2=BS|title=Recognition of the DNA minor groove by pyrrole-imidazole polyamides.|journal=Current Opinion in Structural Biology|date=June 2003|volume=13|issue=3|pages=284–99|pmid=12831879|accessdate=|doi=10.1016/s0959-440x(03)00081-2}}
22. ^{{cite journal|last1=Swalley|first1=Susanne E.|last2=Baird|first2=Eldon E.|last3=Dervan|first3=Peter B.|title=A Pyrrole-Imidazole Polyamide Motif for Recognition of Eleven Base Pair Sequences in the Minor Groove of DNA|journal=Chemistry - A European Journal|date=October 1997|volume=3|issue=10|pages=1600–1607|doi=10.1002/chem.19970031009}}
23. ^{{cite journal|last1=White|first1=Sarah|last2=Baird|first2=Eldon E.|last3=Dervan|first3=Peter B.|title=On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides|journal=Chemistry & Biology|date=August 1997|volume=4|issue=8|pages=569–578|doi=10.1016/S1074-5521(97)90243-X}}
24. ^1 2 {{cite web |url=https://www.nsf.gov/news/news_summ.jsp?cntn_id=109741 |title=2006 National Medal of Science Winners |accessdate=2009-02-08 |website= |publisher=United States Government |date= }}
25. ^[https://www.nsf.gov/od/nms/recip_details.cfm?recip_id=5300000000437 National Science Foundation - The President's National Medal of Science]
26. ^1 2 3 4 5 6 7 {{cite news|last1=Mantell|first1=Suzanne|title=A day at the races|url=http://bcm.bc.edu/issues/spring_2008/works/a-day-at-the-races.html|accessdate=14 June 2017|work=Boston College Magazine}}
27. ^{{cite book|last1=Schmadel|first1=Lutz|title=Dictionary of Minor Planet Names: Addendum to 6th Edition: 2012-2014|date=2014|publisher=Springer|location=New York|page=48|url=https://books.google.com/books?id=dzBsCQAAQBAJ&pg=PA48|accessdate=14 June 2017|isbn=9783319176772}}
28. ^{{cite web|title=Past Recipients of the Harrison Howe Award|url=http://www.sas.rochester.edu/chm/howe/past.html|website=Rocherster Section ACS|accessdate=14 June 2017}}
29. ^{{cite web|title=Arthur C. Cope Award|url=https://www.acs.org/content/acs/en/funding-and-awards/awards/national/bytopic/arthur-c-cope-award.html|website=American Chemical Society|accessdate=14 June 2017}}
30. ^{{cite web|title=The Willard Gibbs Meda|url=http://cmliris.harvard.edu/assets/Willard_Gibbs_Medalists.pdf|website=American Chemical Society|accessdate=14 June 2017}}
31. ^{{cite journal|title=AWARDS|journal=Chemical & Engineering News|date=28 March 1994|volume=72|issue=13|pages=48|doi=10.1021/cen-v072n013.p048}}
32. ^1 {{cite news|last1=Avery|first1=John|title=Chemist Wins 1996 Grand Prize from la Maison de la Chimie|url=http://www.staging.caltech.edu/news/chemist-wins-1996-grand-prize-la-maison-de-la-chimie-87|accessdate=14 June 2017|work=Caltech News|date=March 29, 1996}}
33. ^{{cite web|title=Remsen Award|url=http://maryland.sites.acs.org/remsenaward.htm|website=American Chemistry Society|accessdate=14 June 2017}}
34. ^{{cite journal|title=1998 Remsen Award|url=http://maryland.sites.acs.org/Chesapeake%20Chemist/Archives/1998/May-1998.pdf|accessdate=14 June 2017|journal=The Chesapeake Chemist|volume=LIV|issue=5|date=1998|pages=1, 4}}
35. ^1 2 3 {{cite news|title=Pioneering Organic Chemist Elected to Yale Board of Trustees|url=http://news.yale.edu/2008/06/04/pioneering-organic-chemist-elected-yale-board-trustees|accessdate=14 June 2017|work=Yale News|date=June 4, 2008}}
36. ^{{cite web|title=Alfred Bader Award in Bioinorganic or Bioorganic Chemistry|url=https://www.acs.org/content/acs/en/funding-and-awards/awards/national/bytopic/alfred-bader-award-in-bioinorganic-or-bioorganic-chemistry.html|website=American Chemical Society|accessdate=14 June 2017}}
37. ^{{cite web|title=Max Tishler Prize Lecturers|url=https://chemistry.harvard.edu/tishler|website=Harvard University|accessdate=14 June 2017}}
38. ^{{cite web|title=The Pauling Medal Awardees|url=https://paulingblog.wordpress.com/2016/04/27/the-pauling-medal-awardees/|website=The Pauling Blog|date=April 27, 2016|accessdate=14 June 2017}}
39. ^{{cite web|title=Tolman Award|url=http://scalacs.org/?page_id=20|website=SCALACS|accessdate=14 June 2017|date=2006-01-10}}
40. ^1 2 3 4 5 6 7 8 {{cite journal|last1=Dervan|first1=Peter B.|title=Molecular Recognition of DNA by Small Molecules (personal essay in acceptance of the Tetrahedron Prize)|journal=Bioorganic & Medicinal Chemistry|date=2001|volume=9|issue=9|pages=2215–2235|url=http://n.ethz.ch/~nbennett/download/Reading_NEW/DNA%20recognition/Dervan.pdf|accessdate=14 June 2017|doi=10.1016/s0968-0896(01)00262-0}}
41. ^{{cite web|title=Prize Winners|url=https://harveypz.net.technion.ac.il/harvey-prize-laureates/|website=Harvey Prize|accessdate=14 June 2017}}
42. ^{{cite web|title=Ronald Breslow Award for Achievement in Biomimetic Chemistry|url=https://www.acs.org/content/acs/en/funding-and-awards/awards/national/bytopic/ronald-breslow-award-for-achievement-in-biomimetic-chemistry.html|website=American Chemical Society|accessdate=14 June 2017}}
43. ^{{cite web|title=Medalists by Year|url=http://www.aya.yale.edu/content/medalists-year|website=Yale Alumni Association|accessdate=14 June 2017}}
44. ^{{cite web|title=Frank H. Westheimer Prize Lecturers|url=https://chemistry.harvard.edu/westheimer|website=Harvard University|accessdate=14 June 2017}}
45. ^{{cite journal|title=Meet Jacqueline K. Barton, 2015 Priestley Medalist|journal=Chemical & Engineering News|date=Mar 23, 2015|volume=93|issue=12|url=http://cen.acs.org/articles/93/i12/Meet-Jaqueline-K-Barton-2015.html|accessdate=2 April 2015}}
46. ^1 2 3 4 5 {{cite news|last1=Wohl|first1=Shirlee|title=Peter Dervan, GRD ‘72|url=http://www.yalescientific.org/2011/11/peter-dervan-grd-72/|accessdate=14 June 2017|work=Yale Scientific|date=November 16, 2011}}

External links

  • Personal biography
{{Winners of the National Medal of Science|chemistry}}{{ACS Chemical Biology Lectureship}}{{Authority control}}{{DEFAULTSORT:Dervan, Peter B}}

12 : 1945 births|Living people|Organic chemists|21st-century American chemists|Members of the United States National Academy of Sciences|Gilead Sciences|National Medal of Science laureates|Members of the French Academy of Sciences|California Institute of Technology faculty|Boston College alumni|University of Wisconsin–Madison alumni|Yale University alumni
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