| 词条 | Pethidine intermediate A |
| 释义 |
| verifiedrevid = 412260743 | IUPAC_name = 1-methyl-4-phenylpiperidine-4-carbonitrile | image = Pethidineintermediate.svg | width = 160 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Schedule II | legal_UN = N I | legal_DE = Anlage II | routes_of_administration = N/A | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 3627-62-1 | ATC_prefix = none | ATC_suffix = | PubChem = 62513 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID = 56289 | C=13 | H=16 | N=2 | molecular_weight = 200.28 g/mol | synonyms = | smiles = CN1CCC(CC1)(C#N)c2ccccc2 | StdInChI = 1S/C13H16N2/c1-15-9-7-13(11-14,8-10-15)12-5-3-2-4-6-12/h2-6H,7-10H2,1H3 | StdInChIKey = ZLFQTZYFXYOGLS-UHFFFAOYSA-N }}Pethidine intermediate A is a 4-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active,[1] so pethidine intermediate A might also show opioid effects. It is scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9232. The 2014 annual manufacturing quota was 6 grammes (as an end product, presumably for research use). [2] See also
References1. ^Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML. Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine Transporters. Journal of Medicinal Chemistry. 2005; 48:1336-1343. 2. ^http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html 3 : Synthetic opioids|Piperidines|Nitriles |
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