| 词条 | Phenibut | |||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
| Verifiedfields = verified | Watchedfields = verified | verifiedrevid = 464373947 | IUPAC_name = 4-Amino-3-phenylbutanoic acid | image = Phenibut skeletal formula.svg | width = 200px | image2 = Phenibut ball-and-stick model.png | width2 = 200px | tradename = Anvifen, Fenibut, Noofen, others[1] | pregnancy_AU = | pregnancy_US = | dependency_liability = | addiction_liability = | legal_AU = S9 | legal_CA = | legal_UK = | legal_US = Not FDA-approved; unscheduled | legal_status = RU: ℞-only | routes_of_administration = Common: By mouth[2] Uncommon: Rectal[2] | class = GABA receptor agonist; Gabapentinoid | bioavailability = Well-absorbed[2] ≥63% (250 mg)[5] | protein_bound = | metabolism = Liver (minimal)[2][5] | metabolites = Inactive[2] | elimination_half-life = 5.3 hours (250 mg)[5] | onset = Oral: 2–4 hours[2] Rectal: 20–30 minutes[2] | duration_of_action = 15–24 hours (1–3 g)[2] | excretion = Urine: 63% (unchanged)[5] | CAS_number_Ref = {{cascite|correct|CAS}} | CAS_number = 1078-21-3 | CAS_supplemental = 3060-41-1 (hydrochloride) | UNII_Ref = {{fdacite|changed|FDA}} | UNII = T2M58D6LA8 | ATC_prefix = N06 | ATC_suffix = BX22 | PubChem = 14113 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 13491 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 315818 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D10509 | synonyms = Aminophenylbutyric acid; Fenibut; Fenigam; Phenigam; Phenybut; Phenygam; Phenylgamma; Phenigama; PHG; PhGABA; β-Phenyl-γ-aminobutyric acid; β-Phenyl-GABA[3] | C=10 | H=13 | N=1 | O=2 | molecular_weight = 179.216 g/mol | SMILES = O=C(O)CC(c1ccccc1)CN | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C10H13NO2/c11-7-9(6-10(12)13)8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H,12,13) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = DAFOCGYVTAOKAJ-UHFFFAOYSA-N | melting_point = 253 }}Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others,[1] is a central nervous system depressant with anxiolytic and stimulant effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications.[4] It is usually taken by mouth as a tablet, but can also be given as an intravenous infusion.[4][2][19][20]Side effects of phenibut include sedation, sleepiness, nausea, irritability, agitation, dizziness, and headache, among others.[2][19] Overdose of phenibut can produce marked central nervous system depression including unconsciousness, although no deaths have been reported.[2][19][2] The medication is structurally related to the neurotransmitter γ-aminobutyric acid (GABA), and hence is a GABA analogue.[4] Phenibut is thought to act as a GABAB receptor agonist, similarly to baclofen and γ-hydroxybutyrate (GHB).[4] However, at low concentrations, phenibut mildly increases the concentration of dopamine in the brain, providing stimulatory effects in addition to the anxiolysis.[5] Subsequent research has found that it is also a potent blocker of α2δ subunit-containing voltage-dependent calcium channels (VDCCs), similarly to gabapentinoids like gabapentin and pregabalin.[29][30] Phenibut was developed in the Soviet Union and was introduced for medical use in the 1960s.[4] Today, it is marketed for medical use in Russia, Ukraine, Kazakhstan, and Latvia.[4] The medication is not approved for clinical use in the United States and most of Europe, but it is also sold on the Internet as a supplement and purported nootropic.[2][2] Phenibut has been used recreationally and can produce euphoria as well as addiction, dependence, and withdrawal.[2] It is a controlled substance in Australia, and it has been suggested that its legal status should be reconsidered in Europe as well.[2][2] Medical usesPhenibut is used in Russia, Ukraine, and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia).[4][2] It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease, dizziness, for the prevention of motion sickness, and for the prevention of anxiety before or after surgical procedures or painful diagnostic tests.[4][2] Available formsPhenibut is available as a medication in the form of 250 mg tablets for oral administration and as a solution at a concentration of 10 mg/mL for infusion.[2][6][20] ContraindicationsContraindications of phenibut include:[2][6]
Phenibut should not be combined with alcohol.[6] Side effectsPhenibut is generally well-tolerated.[6][4] Possible side effects may include sedation, somnolence, nausea, irritability, agitation, anxiety, dizziness, headache, and allergic reactions such as skin rash and itching.[2][6] At high doses, motor incoordination, loss of balance, and hangovers may occur.[2] Tolerance develops to phenibut with repeated use.[4] Withdrawal symptoms may occur upon discontinuation, and, in recreational users taking high doses, have been reported to include severe rebound anxiety, insomnia, anger, irritability, agitation, visual and auditory hallucinations, and acute psychosis.[2] Due to its central nervous system depressant effects, people taking phenibut should refrain from potentially dangerous activities such as operating heavy machinery.[2][6] With prolonged use of phenibut, particularly at high doses, the liver and blood should be monitored, due to risk of fatty liver disease and eosinophilia.[2][6] OverdoseIn overdose, phenibut can cause severe drowsiness, nausea, vomiting, eosinophilia, lowered blood pressure, renal impairment, and, above 7 grams, fatty liver degeneration.[2][6] There are no specific antidotes for phenibut overdose.[6] Lethargy, somnolence, agitation, delirium, tonic–clonic seizures, reduced consciousness or unconsciousness, and unresponsiveness have been reported in recreational users who have overdosed.[2] Management of phenibut overdose includes activated charcoal, gastric lavage, induction of vomiting, and symptom-based treatment.[2][6] Unlike certain other related central nervous system depressants such as baclofen and GHB, there have been no reports of death in association with phenibut overdose.[2] InteractionsPhenibut may mutually potentiate and extend the duration of the effects of other central nervous system depressants including anxiolytics, antipsychotics, sedatives, opioids, anticonvulsants, and alcohol.[2][6] Pharmacology{{See also|Gabapentinoid#Pharmacology}}Pharmacodynamics
Phenibut acts as a full agonist of the GABAB receptor, similarly to baclofen.[8][9] It has between 30- to 68-fold lower affinity for the GABAB receptor than baclofen, and, in accordance, is used at far higher doses in comparison.[8] (R)-Phenibut has more than 100-fold higher affinity for the GABAB receptor than does (S)-phenibut; hence, (R)-phenibut is the active enantiomer at the GABAB receptor.[10] At very high concentrations, phenibut reportedly also acts as an agonist of the GABAA receptor, which is the receptor responsible for the actions of the benzodiazepines, barbiturates, and alcohol.[11]
Phenibut also binds to and blocks α2δ subunit-containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid.[12][13] Both (R)-phenibut and (S)-phenibut display this action with similar affinity (Ki = 23 and 39 μM, respectively).[12] Moreover, (R)-phenibut possesses 4-fold greater affinity for this site than for the GABAB receptor (Ki = 92 μM), while (S)-phenibut does not bind significantly to the GABAB receptor (Ki > 1 mM).[12] As such, based on the results of this study, phenibut would appear to have much greater potency in its interactions with α2δ subunit-containing VDCCs than with the GABAB receptor (between 5- to 10-fold).[12] For this reason, the actions of phenibut as a α2δ subunit-containing voltage-gated calcium channel blocker or gabapentinoid may be its true primary mechanism of action, and this may explain the differences between phenibut and its close relative baclofen (which, in contrast, has essentially insignificant activity as a gabapentinoid; Ki = 6 μM for the GABAB receptor and Ki = 156 μM for α2δ subunit-containing VDCCs, or a 26-fold difference in affinity).[12][14] (R)-Phenibut and (S)-phenibut have been assayed at 85 binding sites at a concentration of 100 µM with no activity (less than 20% inhibition of binding) observed except at the α2δ VDCC subunit and the GABAB receptor.[15] In this study, (R)-phenibut and (S)-phenibut showed IC50 values for inhibition of gabapentin binding of 87.1 µM and 91.0 µM (Ki = 60 µM), respectively.[15] The IC50 for gabapentin under the same conditions was 0.09 µM.[15] The researchers also assessed phenibut at the GABAB receptor and found a Ki value of 57 µM for (R)-phenibut, which would be about twice that concentration (~114 µM) with racemic phenibut.[15] PharmacokineticsVery little information has been published on the clinical pharmacokinetics of phenibut.[4] The drug is reported to be well-absorbed.[2] It distributes widely throughout the body and across the blood–brain barrier.[2] Approximately 0.1% of an administered dose of phenibut reportedly penetrates into the brain, with this said to occur to a much greater extent in young people and the elderly.[2] Following a single 250 mg dose in healthy volunteers, its elimination half-life was approximately 5.3 hours and the drug was largely (63%) excreted in the urine unchanged.[4] In animals, the absolute bioavailability of phenibut was 64% after oral and intravenous administration, it appeared to undergo minimal or no metabolism in multiple species, and it crossed the blood–brain barrier to a significantly greater extent than GABA.[4] The metabolites of phenibut are reported to be inactive.[2] Some limited information has been described on the pharmacokinetics of phenibut in recreational users taking much higher doses (e.g., 1–3 grams) than typical clinical doses.[16][17] In these individuals, the onset of action of phenibut has been reported to be 2 to 4 hours orally and 20 to 30 minutes rectally, the peak effects are described as occurring 4 to 6 hours following oral ingestion, and the total duration for the oral route has been reported to be 15 to 24 hours (or about 3 to 5 terminal half-lives).[16] ChemistryPhenibut is a synthetic aromatic amino acid. It is a chiral molecule and thus has two potential configurations, as (R)- and (S)-enantiomers.[9] Structure and analoguesPhenibut is a derivative of the inhibitory neurotransmitter GABA.[4] Hence, it is a GABA analogue.[4] Phenibut is specifically the analogue of GABA with a phenyl ring substituted in at the β-position.[4] As such, its chemical name is β-phenyl-γ-aminobutyric acid, which can be abbreviated as β-phenyl-GABA.[4] The presence of the phenyl ring allows phenibut to cross the blood–brain barrier significantly, unlike the case of GABA.[4] Phenibut also contains the trace amine β-phenethylamine in its structure.[4] Phenibut is closely related to a variety of other GABA analogues including baclofen (β-(4-chlorophenyl)-GABA), 4-fluorophenibut (β-(4-fluorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), pregabalin ((S)-β-isobutyl-GABA), gabapentin (1-(aminomethyl)cyclohexane acetic acid), and GABOB (β-hydroxy-GABA).[4][12] It has almost the same chemical structure as baclofen, differing from it only in having a hydrogen atom instead of a chlorine atom at the para position of the phenyl ring.[4] Phenibut is also close in structure to pregabalin, which has an isobutyl group at the β position instead of phenibut's phenyl ring.[12] A glutamate-derivative analogue of phenibut is glufimet (dimethyl 3-phenylglutamate hydrochloride).[18] SynthesisA chemical synthesis of phenibut has been published.[19] HistoryPhenibut was synthesized at the A. I. Herzen Leningrad Pedagogical Institute (USSR) by Professor Vsevolod Perekalin's team and tested at the Institute of Experimental Medicine, USSR Academy of Medical Sciences.[4] It was introduced into clinical use in Russia in the 1960s.[4] Society and cultureGeneric namesThe generic name of phenibut is fenibut, phenibut, or phenybut (Russian: фенибут).[3] It is also sometimes referred to as aminophenylbutyric acid (Russian: аминофенилмасляная кислота).[1] The word phenibut is a contraction of the chemical name of the drug, β-phenyl-γ-aminobutyric acid.[4] In early publications, phenibut was referred to as fenigam and phenigama (and spelling variants thereof; Russian: фенигам and фенигама).[4][20] The drug has not been assigned an {{abbrlink|INN|International Nonproprietary Name}}.[2][3] Brand namesPhenibut is marketed in Russia, Ukraine, and Latvia under the brand names Anvifen, Fenibut, Bifren and Noofen (Russian: Анвифен, Фенибут, Бифрен and Ноофен, respectively).[1] AvailabilityPhenibut is approved in Russia, Ukraine, and Latvia for medical use.[16] It is not approved or available as a medication in other countries in the European Union, the United States, or Australia.[16] In countries where phenibut is not a licensed pharmaceutical drug, it is sold online without a prescription as a "nutritional supplement".[16] It is often used as a form of self-medication for social anxiety.[16] Recreational usePhenibut is used recreationally due to its ability to produce euphoria, anxiolysis, and increased sociability.[16] Because of its delayed onset of effects, first-time users often mistakenly take an additional dose of phenibut in the belief that the initial dose did not work.[16] Recreational users usually take the drug orally; there are a few case reports of rectal administration and one report of insufflation, which was described as "very painful" and causing swollen nostrils.[16] Legal statusAs of 2018, phenibut is not a controlled substance in any country apart from Australia[21] and Hungary.[22] In 2015, it was suggested that the legal status of phenibut in Europe should be reconsidered due to its recreational potential.[16] In February 2018, the Australian Therapeutic Goods Administration declared it a prohibited (schedule 9) substance, citing health concerns due to withdrawal and overdose.[23][24] As of 14 November 2018, Hungary added phenibut and 10 other items to its New Psychoactive Substances ban list.{{cn|date=January 2019}} References1. ^1 2 3 {{cite journal | last1 = Drobizhev | first1 = M.Yu. | last2 = Fedotova | first2 = A.V. | last3 = Kikta | first3 = S.V. | last4 = Antohin | first4 = E.Yu. | year = 2016 | title = Феномен аминофенилмасляной кислоты | trans-title = [Phenomenon of aminophenylbutyric acid] | url = https://www.rmj.ru/articles/nevrologiya/Fenomen_aminofenilmaslyanoy_kisloty/ | language = Russian | journal = Russian Medical Journal | volume = 2017 | issue = 24 | pages = 1657–1663 | issn = 1382-4368}} {{Navboxes2. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 {{cite | author = Ozon Pharm | title = Fenibut | accessdate = 15 September 2017 | format = PDF | url = http://www.ozonpharm.ru/upload/iblock/608/nmntxzabdzjhlu%20-%20fbdoqpbtdj.ofzsxp%20tkbgeygfzj.pdf}} 3. ^1 2 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA69|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=69–}} 4. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 {{Cite journal| last1 = Lapin | first1 = I.| title = Phenibut (beta-phenyl-GABA): A tranquilizer and nootropic drug| journal = CNS Drug Reviews| volume = 7| issue = 4| pages = 471–481| year = 2001| pmid = 11830761| doi = 10.1111/j.1527-3458.2001.tb00211.x}} 5. ^{{Cite journal|last=Lapin|first=Izyaslav|date=2006-06-07|title=Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug|journal=CNS Drug Reviews|language=en|volume=7|issue=4|pages=471–481|doi=10.1111/j.1527-3458.2001.tb00211.x|issn=1080-563X}} 6. ^1 2 3 4 5 6 7 8 9 10 11 12 13 {{cite web | author = Регистр лекарственных средств России ([Russian Medicines Register]) | title = Фенибут (Phenybutum) | trans-title = Fenibut (Phenybutum) | accessdate = 15 September 2017 | url = https://www.rlsnet.ru/tn_index_id_5320.htm}} 7. ^{{cite journal | vauthors = Bowery NG, Hill DR, Hudson AL | title = Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes | journal = Br. J. Pharmacol. | volume = 78 | issue = 1 | pages = 191–206 | year = 1983 | pmid = 6297646 | pmc = 2044790 | doi = 10.1111/j.1476-5381.1983.tb09380.x| url = }} 8. ^1 {{cite book|title=GABAb Receptor Pharmacology: A Tribute to Norman Bowery: A Tribute to Norman Bowery|url=https://books.google.com/books?id=_iMDQOA2UIsC&pg=PA25|date=21 September 2010|publisher=Academic Press|isbn=978-0-12-378648-7|pages=25–}} 9. ^1 {{cite journal | vauthors = Dambrova M, Zvejniece L, Liepinsh E, Cirule H, Zharkova O, Veinberg G, Kalvinsh I | title = Comparative pharmacological activity of optical isomers of phenibut | journal = Eur. J. Pharmacol. | volume = 583 | issue = 1 | pages = 128–34 | year = 2008 | pmid = 18275958 | doi = 10.1016/j.ejphar.2008.01.015 | url = }} 10. ^{{cite journal|last1=Allan|first1=R.D.|last2=Bates|first2=M.C.|last3=Drew|first3=C.A.|last4=Duke|first4=R.K.|last5=Hambley|first5=T.W.|last6=Johnston|first6=G.A.R.|last7=Mewett|first7=K.N.|last8=Spence|first8=I.|title=A new synthesis resolution and in vitro activities of (R)- and (S)-β-Phenyl-Gaba|journal=Tetrahedron|volume=46|issue=7|year=1990|pages=2511–2524|issn=0040-4020|doi=10.1016/S0040-4020(01)82032-9}} 11. ^{{cite journal|last1=Zyablitseva|first1=Evgeniya A.|last2=Kositsyn|first2=Nikolay S.|last3=Shul'gina|first3=Galina I.|title=The Effects of Agonists of Ionotropic GABAA and Metabotropic GABAB Receptors on Learning|journal=The Spanish Journal of Psychology|volume=12|issue=1|year=2013|pages=12–20|issn=1138-7416|doi=10.1017/S1138741600001438|pmid=19476215}} 12. ^1 2 3 4 5 6 7 8 {{cite journal|year=2015|title=R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects|url=|journal=Pharmacol. Biochem. Behav.|volume=137|issue=|pages=23–9|doi=10.1016/j.pbb.2015.07.014|pmid=26234470|vauthors=Zvejniece L, Vavers E, Svalbe B, Veinberg G, Rizhanova K, Liepins V, Kalvinsh I, Dambrova M}} 13. ^{{cite journal | vauthors = Vavers E, Zvejniece L, Svalbe B, Volska K, Makarova E, Liepinsh E, Rizhanova K, Liepins V, Dambrova M | title = The neuroprotective effects of R-phenibut after focal cerebral ischemia | journal = Pharmacol. Res. | volume = 113 | issue = Pt B | pages = 796–801 | year = 2016 | pmid = 26621244 | doi = 10.1016/j.phrs.2015.11.013 | url = }} 14. ^1 2 {{cite book | vauthors = Froestl W | title = Chemistry and pharmacology of GABAB receptor ligands | journal = Adv. Pharmacol. | volume = 58 | issue = | pages = 19–62 | year = 2010 | pmid = 20655477 | doi = 10.1016/S1054-3589(10)58002-5 | url = | series = Advances in Pharmacology | isbn = 9780123786470 }} 15. ^1 2 3 {{cite journal | vauthors = Belozertseva I, Nagel J, Valastro B, Franke L, Danysz W | title = Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain | journal = Pharmacol Rep | volume = 68 | issue = 3 | pages = 550–4 | year = 2016 | pmid = 26894962 | doi = 10.1016/j.pharep.2015.12.004 | url = }} 16. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 {{cite journal | vauthors = Owen DR, Wood DM, Archer JR, Dargan PI | title = Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity | journal = Drug Alcohol Rev | volume = 35 | issue = 5 | pages = 591–6 | year = 2016 | pmid = 26693960 | doi = 10.1111/dar.12356 | url = | hdl = 10044/1/30073 }} 17. ^{{cite journal | vauthors = Schifano F, Orsolini L, Duccio Papanti G, Corkery JM | title = Novel psychoactive substances of interest for psychiatry | journal = World Psychiatry | volume = 14 | issue = 1 | pages = 15–26 | year = 2015 | pmid = 25655145 | pmc = 4329884 | doi = 10.1002/wps.20174 | url = }} 18. ^{{cite journal | vauthors = Perfilova VN, Popova TA, Prokofiev II, Mokrousov IS, Ostrovskii OV, Tyurenkov IN | title = Effect of Phenibut and Glufimet, a Novel Glutamic Acid Derivative, on Respiration of Heart and Brain Mitochondria from Animals Exposed to Stress against the Background of Inducible NO-Synthase Blockade | journal = Bull. Exp. Biol. Med. | volume = 163 | issue = 2 | pages = 226–229 | date = June 2017 | pmid = 28726197 | doi = 10.1007/s10517-017-3772-4 | url = }} 19. ^1 2 {{cite | last1 = Sivchik | first1 = V.V. | last2 = Grygoryan | first2 = H.O. | last3 = Survilo | first3 = V.L. | last4 = Trukhachova | first4 = T.V. | title = Синтез γ-амино-β-фенилмасляной кислоты (фенибута) | trans-title = [Synthesis of β-phenyl-γ-aminobutyric acid (phenibut) | year = 2012 | format = PDF | url = http://elib.bsu.by/bitstream/123456789/15950/1/C%D0%91%D0%9E%D0%A0%D0%9D%D0%98%D0%9A%202012.pdf#page=448}} 20. ^{{cite journal|last1=Khaunina|first1=R. A.|last2=Lapin|first2=I. P.|title=Fenibut, a new tranquilizer|journal=Pharmaceutical Chemistry Journal|volume=10|issue=12|year=1976|pages=1703–1705|issn=0091-150X|doi=10.1007/BF00760021}} 21. ^{{cite journal | vauthors = Owen DR, Wood DM, Archer JR, Dargan PI | title = Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity | journal = Drug Alcohol Rev | volume = 35 | issue = 5 | pages = 591–6 | year = 2016 | pmid = 26693960 | doi = 10.1111/dar.12356 | url = | hdl = 10044/1/30073 }} 22. ^{{Cite web|url=http://kozlonyok.hu/nkonline/MKPDF/hiteles/MK18170.pdf|title=39/2018. (XI. 8.) EMMI rendelet Az új pszichoaktív anyaggá minősített anyagokról vagy vegyületcsoportokról szóló 55/2014. (XII. 30.) EMMI rendelet módosításáról|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}} 23. ^{{cite web|last1=Administration|first1=Australian Government Department of Health. Therapeutic Goods|title=3.3 Phenibut|url=https://www.tga.gov.au/book-page/33-phenibut|website=Therapeutic Goods Administration (TGA)|accessdate=6 November 2017|language=en|date=31 October 2017}} 24. ^{{cite web |url=http://www.abc.net.au/news/2018-02-22/detectives-probe-if-drug-behind-school-overdose-bought-online/9471958 | title = Mass school overdose investigation focuses on banned Russian drug | publisher= Australian Broadcasting Corporation | date= 22 Feb 2018 | accessdate = 22 Feb 2018}} | title = Medical uses | titlestyle = background:#ccccff | list1 ={{Anxiolytics}}{{Hypnotics/sedatives}}{{Insomnia pharmacotherapies}}{{Treatment of drug dependence}} }}{{Navboxes | title = Recreational uses | titlestyle = background:#ccccff | list1 ={{Euphoriants}}{{Recreational drug use}} }}{{Navboxes | title = Pharmacodynamics | titlestyle = background:#ccccff | list1 ={{GABA receptor modulators}}{{Ion channel modulators}} }} 17 : Analgesics|Anticonvulsants|Anxiolytics|Bodybuilding supplements|Calcium channel blockers|Drug culture|Drugs in the Soviet Union|Euphoriants|GABA analogues|GABAA receptor agonists|GABAB receptor agonists|Hypnotics|Muscle relaxants|Nootropics|Phenethylamines|Russian drugs|Stimulants |
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