| 词条 | Phenol-soluble modulin |
| 释义 |
MRSA production of PSMs is thought to be a possible cause of severe infections.[3] PSM production is higher in community-acquired MRSA (CA-MRSA) than in healthcare-associated MRSA (HA-MRSA),[4] and consequently CA-MRSA associated osteomyelitis[4] is more severe than HA-MRSA associated osteomyelitis. Genetic analysis demonstrated that the PSM-alpha protein, product of the psm-alpha gene cluster, was associated with enhanced virulence and enhanced destruction of white blood cells, presumably the key to the higher infectivity. However, expression of the psm-alpha genes appeared to vary, dependent upon unknown factors specific to each particular infection.[5]References1. ^{{Cite journal|last=Berube|first=Bryan J.|last2=Sampedro|first2=Georgia R.|last3=Otto|first3=Michael|last4=Bubeck Wardenburg|first4=Juliane|date=2014-08-01|title=The psmα locus regulates production of Staphylococcus aureus alpha-toxin during infection|journal=Infection and Immunity|volume=82|issue=8|pages=3350–3358|doi=10.1128/IAI.00089-14|issn=1098-5522|pmc=4136214|pmid=24866799}} {{Protein-stub}}2. ^{{Cite web|url=http://www.nature.com/nrmicro/journal/v11/n10/pdf/nrmicro3110.pdf|title=Phenol-soluble modulins and staphylococcal infection|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}} 3. ^{{Cite journal|last2=Kobayashi|first2=S. D.|last3=Deleo|first3=F. R.|year=2010|title=Community-associated methicillin-resistant Staphylococcus aureus immune evasion and virulence|journal=Journal of Molecular Medicine|volume=88|issue=2|pages=109–114|doi=10.1007/s00109-009-0573-x|pmc=2852573|pmid=20049412|last1=Graves|first1=S. F.}} 4. ^1 {{Cite journal|last=Rasigade|first=Jean-Philippe|last2=Trouillet-Assant|first2=Sophie|last3=Ferry|first3=Tristan|last4=Diep|first4=Binh An|last5=Sapin|first5=Anaïs|last6=Lhoste|first6=Yannick|last7=Ranfaing|first7=Jérémy|last8=Badiou|first8=Cédric|last9=Benito|first9=Yvonne|date=2013-01-01|title=PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts|journal=PLoS One|volume=8|issue=5|pages=e63176|doi=10.1371/journal.pone.0063176|issn=1932-6203|pmc=3653922|pmid=23690994}} 5. ^{{Cite journal | last1 = Wang | first1 = R. | last2 = Braughton | first2 = K. R. | last3 = Kretschmer | first3 = D. | last4 = Bach | first4 = T. H. L. | last5 = Queck | first5 = S. Y. | last6 = Li | first6 = M. | last7 = Kennedy | first7 = A. D. | last8 = Dorward | first8 = D. W. | last9 = Klebanoff | first9 = S. J. | last10 = Peschel | doi = 10.1038/nm1656 | first10 = A. | last11 = Deleo | first11 = F. R. | last12 = Otto | first12 = M. | title = Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA | journal = Nature Medicine | volume = 13 | issue = 12 | pages = 1510–1514 | year = 2007 | pmid = 17994102| pmc = }} 3 : Staphylococcaceae|Bacterial toxins|Occupational safety and health |
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