“Phenylglyoxylate dehydrogenase (acylating)”的意思、由来-开放百科全书

词条

Phenylglyoxylate dehydrogenase (acylating)

释义

References

{{enzyme
| Name = phenylglyoxylate dehydrogenase (acylating)
| EC_number = 1.2.1.58
| CAS_number = 205510-78-7
| IUBMB_EC_number = 1/2/1/58
| GO_code = 0047110
| image =
| width =
| caption =
}}

In enzymology, a phenylglyoxylate dehydrogenase (acylating; {{EC number|1.2.1.58}}) is an enzyme that catalyzes the chemical reaction

phenylglyoxylate + NAD⁺ + CoA-SH benzoyl-S-CoA + CO₂ + NADH

The three substrates of this enzyme are phenylglyoxylate, NAD⁺, and CoA-SH, whereas its 3 products are benzoyl-S-CoA, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phenylglyoxylate:NAD+ oxidoreductase. It has 3 cofactors: FAD, Thiamin diphosphate, and Iron-sulfur.

References

{{cite journal |vauthors=Hirsch W, Schagger H, Fuchs G | date = 1998 | title = Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Azoarcus evansii | journal = Eur. J. Biochem. | volume = 251 | pages = 907–15 | pmid = 9490067 | doi = 10.1046/j.1432-1327.1998.2510907.x | issue = 3 }}

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