| 释义 |
- Notes
- References
- External links
{{Autobiography|date=February 2013}}{{Infobox person
|name = Philip Seeman
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|birth_date = {{Birth date and age|1934|2|8}}
|birth_place = Winnipeg, Manitoba
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|awards = Order of Canada
}}Philip Seeman, {{Post-nominals|country=CAN|OC|FRSC}} (born February 8, 1934) is a Canadian schizophrenia researcher and neuropharmacologist, known for his research on dopamine receptors. Born in Winnipeg, Manitoba, Seeman was raised in Montreal. He received a Bachelor of Science degree, honours Physics & Physiology (1955), a Master of Science degree, Physiology of Transport & Secretion (1956), and a Doctor of Medicine (1960) from McGill University. In 1966, he received a Ph.D. in Life Sciences from Rockefeller University. In 1967, Seeman became an Assistant Professor in the Department of Pharmacology at the University of Toronto. In 1970, he was appointed a Professor. In 1974, having spent years in search for the binding site of antipsychotic medication, he discovered the dopamine D2 receptor, the basis for the dopamine hypothesis of schizophrenia.[1][2] In 2001, he was made an Officer of the Order of Canada "for his research on dopamine receptors and their involvement in diseases such as schizophrenia, Parkinson's and Huntington's".[3] In 1985, he was made a Fellow of the Royal Society of Canada.[4] Notes1. ^{{Cite journal| author = P. Seeman, M. Chau-Wong, J. Tedesco & K. Wong| title = Brain receptors for antipsychotic drugs and dopamine: direct binding assays| journal = Proceedings of the National Academy of Sciences of the United States of America| volume = 72| issue = 11| pages = 4376–4370|date=November 1975| pmid = 1060115| pmc = 388724| doi = 10.1073/pnas.72.11.4376}}
2. ^{{cite journal|title=People|journal=CMAJ|year=1994|volume=151|number=8|pages= 1186–1187|pmc=1337253}}
3. ^{{OCC|4875}}
4. ^http://www.sciandmed.com/sm/journalviewer.aspx?issue=1066&article=787&action=1
References{{Refbegin}}- {{cite journal | last1 = Madras | first1 = B.K. | year = 2013 | title = History of the discovery of the antipsychotic dopamine D2 receptor: A basis for the dopamine hypothesis of schizophrenia | url = | journal = Journal of the History of the Neurosciences: Basic and Clinical Perspectives | volume = 22 | issue = 1| pages = 62–78 | doi=10.1080/0964704x.2012.678199}}
- {{cite journal | last1 = Seeman | first1 = P. | year = 2011 | title = All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2High receptors | url = | journal = CNS Neuroscience and Therapeutics | volume = 17 | issue = 2| pages = 118–132 | doi=10.1111/j.1755-5949.2010.00162.x}}
- P. Seeman (2010). "Dopamine D2 Receptors as Treatment Targets in Schizophrenia. Clinical Schizophrenia & Related Psychoses April: 56-73.
- P. Seeman (2007), Scholarpedia, 2(10): 3634 doi.4249/scholarpedia.3634
- {{cite journal | last1 = Seeman | first1 = P. | year = 2006 | title = Targeting the dopamine D2 receptor in schizophrenia | url = | journal = Expert Opinion on Therapeutic Targets | volume = 10 | issue = | pages = 515–531 | doi=10.1517/14728222.10.4.515}}
- {{cite journal | last1 = Seeman | first1 = P. | last2 = Weinshenker | first2 = D. | last3 = Quirion | first3 = R. | last4 = Srivastava | first4 = L. | last5 = Bhardwaj | first5 = S.K. | last6 = Grandy | first6 = D.K. | last7 = Premont | first7 = R. | last8 = Sotnikova | first8 = T. | last9 = Boksa | first9 = P. | last10 = El-Ghundi | first10 = M. | last11 = O'Dowd | first11 = B.F. | last12 = George | first12 = S.R. | last13 = Perreault | first13 = M.L. | last14 = Mannisto | first14 = P.T. | last15 = Robinson | first15 = S. | last16 = Palmiter | first16 = R.D. | last17 = Tallerico | first17 = T. | year = 2005 | title = Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis | url = | journal = Proceedings of the National Academy of Sciences USA | volume = 102 | issue = | pages = 3513–3518 | doi=10.1073/pnas.0409766102 | pmid=15716360 | pmc=548961}}
- {{cite journal | last1 = Seeman | first1 = P. | last2 = Chau-Wong | first2 = M. | last3 = Tedesco | first3 = J. | last4 = Wong | first4 = K. | year = 1975 | title = Brain receptors for antipsychotic drugs and dopamine: Direct binding assays | url = | journal = Proceedings of the National Academy of Sciences, USA | volume = 72 | issue = | pages = 4376–4380 | doi=10.1073/pnas.72.11.4376 | pmid=1060115 | pmc=388724}}
{{Refend}}External links- [https://web.archive.org/web/20130529195153/http://www.utoronto.ca/seeman/ Home Page of Philip Seeman's Laboratory]
- Probing the Biology of Psychosis, Schizophrenia, and Antipsychotics: An Expert Interview With Dr. Philip Seeman, MD, PhD - an interview on the Medscape website
- Schizophrenia - an essay by Philip Seeman, November 2001
{{authority control}}{{DEFAULTSORT:Seeman, Philip}} 9 : 1934 births|Living people|Canadian pharmacologists|Fellows of the Royal Society of Canada|Officers of the Order of Canada|People from Winnipeg|Schizophrenia researchers|Neuropharmacologists|Canadian neuroscientists |