“Phosphatidylinositol diacylglycerol-lyase”的意思、由来-开放百科全书

词条

Phosphatidylinositol diacylglycerol-lyase

释义

Structural studies
References

{{enzyme
| Name = phosphatidylinositol diacylglycerol-lyase
| EC_number = 4.6.1.13
| CAS_number = 37288-19-0
| IUBMB_EC_number = 4/6/1/13
| GO_code = 0004436
| image =
| width =
| caption =
}}

In enzymology, a phosphatidylinositol diacylglycerol-lyase ({{EC number|4.6.1.13}}) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-1D-myo-inositol 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

Hence, this enzyme has one substrate, 1-phosphatidyl-1D-myo-inositol, and two products, 1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase, (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase, and (1,2-cyclic-phosphate-forming). This enzyme participates in inositol phosphate metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1T6M}} and {{PDB link|2OR2}}.

References

{{cite journal | vauthors = Allan D, Michell RH | date = 1974 | title = Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0 | journal = Biochem. J. | volume = 142 | pages = 591–7 | pmid = 4377210 | issue = 3 | pmc = 1168323 }}
{{cite journal | vauthors = Friedel RO, Brown JD, Durell | date = 1967 | title = Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain | journal = Biochim. Biophys. Acta | volume = 144 | pages = 684–6 | pmid = 4294905 | issue = 3 | doi=10.1016/0005-2760(67)90059-8}}
{{cite journal | author = Irvine RF | date = 1982 | title = The enzymology of stimulated inositol lipid turnover | journal = Cell Calcium | volume = 3 | pages = 295–309 | pmid = 6297738 | doi = 10.1016/0143-4160(82)90018-5 | issue = 4–5 }}
{{cite journal | vauthors = Michell RH, Allan D | date = 1975 | title = Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus) | journal = FEBS Lett. | volume = 53 | pages = 302–4 | pmid = 236918 | doi = 10.1016/0014-5793(75)80041-X | issue = 3 }}
{{cite journal | vauthors = Low MG, Finean JB | date = 1977 | title = Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C | journal = Biochem. J. | volume = 167 | pages = 281–4 | pmid = 588258 | issue = 1 | pmc = 1183647 }}
{{cite journal | vauthors = Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG | date = 1988 | title = Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C | journal = Nucleic Acids Res. | volume = 16 | pages = 10383 | pmid = 3194218 | doi = 10.1093/nar/16.21.10383 | issue = 21 | pmc = 338883 }}

2 : EC 4.6.1|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。