“Phosphoacetylglucosamine mutase”的意思、由来-开放百科全书

词条

Phosphoacetylglucosamine mutase

释义

Structural studies
References

{{enzyme
| Name = phosphoacetylglucosamine mutase
| EC_number = 5.4.2.3
| CAS_number = 9027-51-4
| IUBMB_EC_number = 5/4/2/3
| GO_code = 0004610
| image =
| width =
| caption =
}}

In enzymology, a phosphoacetylglucosamine mutase ({{EC number|5.4.2.3}}) is an enzyme that catalyzes the chemical reaction

N-acetyl-alpha-D-glucosamine 1-phosphate N-acetyl-D-glucosamine 6-phosphate

Hence, this enzyme has one substrate, N-acetyl-alpha-D-glucosamine 1-phosphate, and one product, N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is N-acetyl-alpha-D-glucosamine 1,6-phosphomutase. Other names in common use include acetylglucosamine phosphomutase, acetylglucosamine phosphomutase, acetylaminodeoxyglucose phosphomutase, phospho-N-acetylglucosamine mutase, and N-acetyl-D-glucosamine 1,6-phosphomutase. This enzyme participates in aminosugars metabolism. This enzyme has at least one effector, N-Acetyl-D-glucosamine 1,6-bisphosphate.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1WJW}}, {{PDB link|2DKA}}, {{PDB link|2DKC}}, and {{PDB link|2DKD}}.

References

{{cite journal | author = Carlson DM | date = 1966 | title = Phosphoacetylglucosamine mutase from pig submaxillary gland; Chapter 24. Phosphoacetylglucosamine mutase from pig submaxillary gland | series = Methods in Enzymology | journal = Methods Enzymol. | volume = 8 | pages = 179–182 | doi = 10.1016/0076-6879(66)08028-5 | isbn = 978-0-12-181808-1 }}
{{cite journal | vauthors = LELOIR LF, CARDINI CE | date = 1956 | title = Enzymes acting on glucosamine phosphate | journal = Biochim. Biophys. Acta | volume = 20 | pages = 33–42 | pmid = 13315346 | doi = 10.1016/0006-3002(56)90259-1 | issue = 1 }}
Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.
{{cite journal |author1 = Reissig JL |author2 =Leloir LF | date = 1966 | title = Phosphoacetylglucosamine mutase from Neurospora; Chapter 23. Phosphoacetylglucosamine mutase from Neurospora | journal = Methods Enzymol. | volume = 8 | pages = 175–178 | doi = 10.1016/0076-6879(66)08027-3 | series = Methods in Enzymology | isbn = 978-0-12-181808-1 }}

2 : EC 5.4.2|Enzymes of known structure

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