“Phosphoadenylyl-sulfate reductase (thioredoxin)”的意思、由来-开放百科全书

词条

Phosphoadenylyl-sulfate reductase (thioredoxin)

释义

Structural studies
References

{{enzyme
| Name = phosphoadenylyl-sulfate reductase (thioredoxin)
| EC_number = 1.8.4.8
| CAS_number = 9068-63-7
| IUBMB_EC_number = 1/8/4/8
| GO_code = 0004604
| image =
| width =
| caption =
}}

In enzymology, a phosphoadenylyl-sulfate reductase (thioredoxin) ({{EC number|1.8.4.8}}) is an enzyme that catalyzes the chemical reaction

adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide 3'-phosphoadenylyl sulfate + thioredoxin

The 3 substrates of this enzyme are adenosine 3',5'-bisphosphate, sulfite, and thioredoxin disulfide, whereas its two products are 3'-phosphoadenylyl sulfate and thioredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming). Other names in common use include PAPS reductase, thioredoxin-dependent, PAPS reductase, thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase, 3'-phosphoadenylylsulfate reductase, thioredoxin:3'-phospho-adenylylsulfate reductase, phosphoadenosine-phosphosulfate reductase, adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin, and oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming). This enzyme participates in sulfur metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1ILO}}, {{PDB link|1WMJ}}, and {{PDB link|2O8V}}.

References

{{cite journal |vauthors=Berendt U, Haverkamp T, Prior A, Schwenn JD | date = 1995 | title = Reaction mechanism of thioredoxin: 3'-phospho-adenylylsulfate reductase investigated by site-directed mutagenesis | journal = Eur. J. Biochem. | volume = 233 | pages = 347–56 | pmid = 7588765 | doi = 10.1111/j.1432-1033.1995.347_1.x | issue = 1 }}

2 : EC 1.8.4|Enzymes of known structure

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