“Phosphonoacetaldehyde hydrolase”的意思、由来-开放百科全书

词条

Phosphonoacetaldehyde hydrolase

释义

Structural studies
References
External links

{{enzyme
| Name = phosphonoacetaldehyde hydrolase
| EC_number = 3.11.1.1
| CAS_number = 37289-42-2
| IUBMB_EC_number = 3/11/1/1
| GO_code = 0050194
| image =
| width =
| caption =
}}

In enzymology, a phosphonoacetaldehyde hydrolase ({{EC number|3.11.1.1}}) is an enzyme that catalyzes the chemical reaction

phosphonoacetaldehyde + H₂O acetaldehyde + phosphate

Thus, the two substrates of this enzyme are phosphonoacetaldehyde and H₂O, whereas its two products are acetaldehyde and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is 2-oxoethylphosphonate phosphonohydrolase. Other names in common use include phosphonatase, and 2-phosphonoacetylaldehyde phosphonohydrolase. This enzyme participates in aminophosphonate metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1SWV}} and {{PDB link|1SWW}}.

References

{{cite journal | vauthors = La Nauze JM, Rosenberg H | date = 1968 | title = The identification of 2-phosphonoacetaldehyde as an intermediate in the degradation of 2-aminoethylphosphonate by Bacillus cereus | journal = Biochim. Biophys. Acta | volume = 165 | pages = 438–47 | pmid = 4982500 | issue = 3 | doi=10.1016/0304-4165(68)90223-7}}
{{cite journal | vauthors = La Nauze JM, Rosenberg H, Shaw DC | date = 1970 | title = The enzymic cleavage of the carbon-phosphorus bond: purification and properties of phosphonatase | journal = Biochim. Biophys. Acta | volume = 212 | pages = 332–50 | pmid = 4989158 | issue = 2 | doi=10.1016/0005-2744(70)90214-7}}
{{cite journal | vauthors = La Nauze JM, Coggins JR, Dixon HB | date = 1977 | title = Aldolase-like imine formation in the mechanism of action of phosphonoacetaldehyde hydrolase | journal = Biochem. J. | volume = 165 | pages = 409–11 | pmid = 200222 | issue = 2 | pmc = 1164914 | doi = 10.1042/bj1650409 }}
{{cite journal | vauthors = Olsen DB, Hepburn TW, Moos M, Mariano PS, Dunaway-Mariano D | date = 1988 | title = Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue | journal = Biochemistry | volume = 27 | pages = 2229–34 | pmid = 3132206 | doi = 10.1021/bi00406a063 | issue = 6 }}
{{cite journal | vauthors = Martin BM, Dunaway-Mariano D | date = 1998 | title = Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis | journal = Biochemistry | volume = 37 | pages = 9305–15 | pmid = 9649311 | doi = 10.1021/bi972677d | issue = 26 }}

External links

{{Commonscatinline}}

2 : EC 3.11.1|Enzymes of known structure

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