| 词条 | Picornavirus internal ribosome entry site (IRES) |
| 释义 |
| Name = Picornavirus internal ribosome entry site (IRES) | image = RF00229.jpg | width = | caption = Predicted secondary structure and sequence conservation of IRES_Picorna | Symbol = IRES_Picorna | AltSymbols = | Rfam = RF00229 | miRBase = | miRBase_family = | RNA_type = Cis-reg; IRES | Tax_domain = Viruses | GO = {{GO|0043022}} | SO = {{SO|0000243}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} This family represents the Picornavirus internal ribosome entry site (IRES). IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.[1][2] References1. ^{{cite journal | last = Ray | first = PS |author2=Das S | year = 2002 | title = La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA | journal = Nucleic Acids Res | volume = 30 | pages = 4500–4508 | pmid = 12384597 | doi = 10.1093/nar/gkf583 | issue = 20 | pmc = 137146}} 2. ^{{cite journal | last = Liu | first = Z |author2=Carthy CM |author3=Cheung P |author4=Bohunek L |author5=Wilson JE |author6=McManus BM |author7=Yang D | year = 1999 | title = Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants | journal = Virology | volume = 265 | pages = 206–217 | pmid = 10600593 | doi = 10.1006/viro.1999.0048 | issue = 2}} External links
3 : Cis-regulatory RNA elements|Internal ribosome entry site|Picornaviridae |
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