| 词条 | Picotamide |
| 释义 |
| verifiedrevid = 464206335 | IUPAC_name = 4-methoxy-N,N-bis(pyridin-3-ylmethyl)isophthalamide | image = picotamide.png | tradename = | Drugs.com = {{drugs.com|international|picotamide}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATC_prefix = B01 | ATC_suffix = AC03 | PubChem = 4814 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 4649 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 654G2VCI4Q | C=21 | H=20 | N=4 | O=3 | molecular_weight = 376.409 g/mol | smiles = O=C(NCc1cccnc1)c3cc(C(=O)NCc2cccnc2)c(OC)cc3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = KYWCWBXGRWWINE-UHFFFAOYSA-N }}Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor.[1] Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.[2] References1. ^{{cite journal|doi=10.1016/S0014-2999(98)00467-1|pmid=9754941|title=Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes|first5=A|last5=Corsini|first4=R|last4=Fumagalli|first3=C|last3=Casagrande|first2=P|year=1998|last2=Quarato|last1=Ratti|first1=S|journal=European Journal of Pharmacology|volume=355|issue=1|pages=77–83}} 2. ^{{cite journal | vauthors = Capra V, Bäck M, Angiolillo DJ, Cattaneo M, Sakariassen KS | title = Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation | journal = Journal of Thrombosis and Haemostasis | volume = 12 | issue = 2 | pages = 126–37 | year = 2014 | pmid = 24298905 | doi = 10.1111/jth.12472 | url = }} External links
4 : Antiplatelet drugs|Pyridines|Benzamides|Phenol ethers |
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