“Platelet alpha-granule”的意思、由来-开放百科全书

Contents include insulin-like growth factor 1, platelet-derived growth factors, TGFβ, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V,^[3] and von Willebrand factor).^[4]

The alpha granules express the adhesion molecule P-selectin^[5] and CD63.^[6] These are transferred to the membrane after synthesis.

Clinical significance

See also

References

1. ^¹{{cite journal | vauthors = Blair P, Flaumenhaft R | title = Platelet alpha-granules: basic biology and clinical correlates | journal = Blood Reviews | volume = 23 | issue = 4 | pages = 177–89 | date = July 2009 | pmid = 19450911 | pmc = 2720568 | doi = 10.1016/j.blre.2009.04.001 }}
2. ^{{cite journal | vauthors = Harrison P, Cramer EM | title = Platelet alpha-granules | journal = Blood Reviews | volume = 7 | issue = 1 | pages = 52–62 | date = March 1993 | pmid = 8467233 | doi = 10.1016/0268-960X(93)90024-X }}
3. ^{{cite journal |vauthors = Whiteheart SW |title=Platelet granules: surprise packages |journal=Blood |date=August 2011 |volume=118 |issue=5 |pages=1190–1191 |doi=10.1182/blood-2011-06-359836|pmid=21816838 }}
4. ^{{cite journal | vauthors = Nurden AT | title = Platelets, inflammation and tissue regeneration | journal = Thrombosis and Haemostasis | volume = 105 | issue = Suppl 1 | pages = S13–33 | date = May 2011 | pmid = 21479340 | doi = 10.1160/THS10-11-0720 | url = https://www.researchgate.net/publication/51038268 }}
5. ^{{cite book | first1 = Stuart H. | last1 = Orkin | first2 = David G. | last2 = Nathan | first3 = David | last3 = Ginsburg | first4 = A. Thomas | last4 = Look | name-list-format = vanc |title=Nathan and Oski's hematology of infancy and childhood|url=https://books.google.com/books?id=_9CmOIvgJm4C&pg=PA1386|access-date=2 November 2010|year=2009|publisher=Elsevier Health Sciences|isbn=978-1-4160-3430-8|pages=1386–}}
6. ^{{cite book | first1 = William B. | last1 = Coleman | first2 = Gregory J. | last2 = Tsongalis | name-list-format = vanc |title=Molecular pathology: the molecular basis of human disease|url=https://books.google.com/books?id=btloapOq85wC&pg=PA258|access-date=2 November 2010|year=2009|publisher=Academic Press|isbn=978-0-12-374419-7|pages=258–}}

词条	Platelet alpha-granule
释义	Contents Clinical significance See also References {{Infobox anatomy \| Name = Alpha granule \| Latin = granulum alpha \| Image = \| Caption = \| Image2 = \| Caption2 = \| Precursor = \| System = \| Artery = \| Vein = \| Nerve = \| Lymph = \| PartOf = Platelets }}Alpha granules (or α-granules) are a cellular component of platelets. Platelets contain different types of granules that perform different functions including alpha granules, dense granules, and lysosomes.^[1] Of these alpha granules are the most common.^[1] The term "alpha granules" is used to describe granules containing several growth factors.^[2] Contents Contents include insulin-like growth factor 1, platelet-derived growth factors, TGFβ, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V,^[3] and von Willebrand factor).^[4] The alpha granules express the adhesion molecule P-selectin^[5] and CD63.^[6] These are transferred to the membrane after synthesis. The other type of granules within platelets are called dense granules. Clinical significance A deficiency of alpha granules is known as gray platelet syndrome. See also Dense granule Platelet rich fibrin References 1. ^¹{{cite journal \| vauthors = Blair P, Flaumenhaft R \| title = Platelet alpha-granules: basic biology and clinical correlates \| journal = Blood Reviews \| volume = 23 \| issue = 4 \| pages = 177–89 \| date = July 2009 \| pmid = 19450911 \| pmc = 2720568 \| doi = 10.1016/j.blre.2009.04.001 }} 2. ^{{cite journal \| vauthors = Harrison P, Cramer EM \| title = Platelet alpha-granules \| journal = Blood Reviews \| volume = 7 \| issue = 1 \| pages = 52–62 \| date = March 1993 \| pmid = 8467233 \| doi = 10.1016/0268-960X(93)90024-X }} 3. ^{{cite journal \|vauthors = Whiteheart SW \|title=Platelet granules: surprise packages \|journal=Blood \|date=August 2011 \|volume=118 \|issue=5 \|pages=1190–1191 \|doi=10.1182/blood-2011-06-359836\|pmid=21816838 }} 4. ^{{cite journal \| vauthors = Nurden AT \| title = Platelets, inflammation and tissue regeneration \| journal = Thrombosis and Haemostasis \| volume = 105 \| issue = Suppl 1 \| pages = S13–33 \| date = May 2011 \| pmid = 21479340 \| doi = 10.1160/THS10-11-0720 \| url = https://www.researchgate.net/publication/51038268 }} 5. ^{{cite book \| first1 = Stuart H. \| last1 = Orkin \| first2 = David G. \| last2 = Nathan \| first3 = David \| last3 = Ginsburg \| first4 = A. Thomas \| last4 = Look \| name-list-format = vanc \|title=Nathan and Oski's hematology of infancy and childhood\|url=https://books.google.com/books?id=_9CmOIvgJm4C&pg=PA1386\|access-date=2 November 2010\|year=2009\|publisher=Elsevier Health Sciences\|isbn=978-1-4160-3430-8\|pages=1386–}} 6. ^{{cite book \| first1 = William B. \| last1 = Coleman \| first2 = Gregory J. \| last2 = Tsongalis \| name-list-format = vanc \|title=Molecular pathology: the molecular basis of human disease\|url=https://books.google.com/books?id=btloapOq85wC&pg=PA258\|access-date=2 November 2010\|year=2009\|publisher=Academic Press\|isbn=978-0-12-374419-7\|pages=258–}} {{Granule contents}}{{Authority control}}{{molecular-cell-biology-stub}}{{circulatory-stub}} 1 : Growth factors
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