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词条 Plectasin
释义

  1. References

Plectasin is an antibiotic found by Novozymes[1] in the Pezizalean fungus Pseudoplectania nigrella. Plectasin belongs to the antimicrobial peptide class called Defensins, which is also present in invertebrates such as flies and mussels. Pre-clinical tests in mice have shown promising results in that multiresistant bacteria have problems mutating resistance against plectasin,[2] which acts by directly binding the bacterial cell-wall precursor Lipid II.[3] At the end of 2008, Novozymes signed a global licensing agreement with Sanofi-Aventis for the further development and marketing of NZ2114, a derivative of plectasin, as a treatment for gram-positive bacterial infections, e.g. Streptococcus and Staphylococcus which are resistant to all existing antibiotics.[1][4]

References

1. ^1 {{cite web|title=Novozymes reveals knowledge on new antibiotic against resistant bacteria|url=http://www.novozymes.com/en/MainStructure/PressAndPublications/PressRelease/2010/Plectasin+in+Science.htm|date=2010-05-28|accessdate=2010-05-28|work=Novozymes}}
2. ^{{cite web|title=Plectasin NZ2114 - Novel Microbial Agent|url=http://www.drugdevelopment-technology.com/projects/plectasin/|accessdate=2010-05-28|work=Drug Development Technology}}
3. ^{{cite journal|title=Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II|work=Science|authors=Kristensen, HH|display-authors=etal|doi=10.1126/science.1185723|year=2010|volume=328|issue=5982|pages=1168–1172|pmid=20508130}}
4. ^{{cite journal|pmc=2704636|title=In Vivo Pharmacodynamic Characterization of a Novel Plectasin Antibiotic, NZ2114, in a Murine Infection Model|authors=Kristensen, HH|display-authors=etal|journal=Antimicrob. Agents Chemother.|year=2009|volume=53|issue=7|pages=3003–3009|doi=10.1128/AAC.01584-08|pmid=19414576}}
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3 : Antibiotics|Peptides|Defensins
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